Innovative Complex Formulation as Topical Treatment for Oral Health Improvment in Periodontal Disease

Cristache, Corina Marilena; Totu, Eugenia Eftimie; Tanase, Gabriela; Nechifor, Aurelia Cristina; Petre, Daniel; Burlibasa, Mihai

Corina Marilena Cristache, Eugenia Eftimie Totu, Gabriela Tanase, Aurelia Cristina Nechifor, Daniel Petre, Mihai Burlibasa

Innovative Complex Formulation as Topical Treatment for Oral Health Improvment in Periodontal Disease

Abstract:

A complex formulation for topical treatment, consisting of melatonin, hyaluronic acid, tetracycline, and metronidazole mixture is proposed as periodontal disease adjunctive treatment. In order to follow the structural aspects of the active mixture, spectrophotometric methods: UV-Vis and fluorescence, have been applied. The results obtained complete our previous studies. By adding metronidazole to the mixture composed of: melatonin, hyaluronic acid, and tetracycline, the conjugated effect of the active compounds, combining antimicrobial action with anti-inflammatory and immunomodulatory effect, is expected to significaly improve supportive therapy in moderate forms of periodontitis.

Keywords:
metronidazole; melatonin; hyaluronic acid; tetracycline; oral health; topical treatment

Issue: 2019, Volume 70, Issue 7

Pages: 2485-2490

Publication date: 2019/8/15

https://doi.org/10.37358/RC.19.7.7366

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
CRISTACHE, C.M., TOTU, E.E., TANASE, G., NECHIFOR, A.C., PETRE, D., BURLIBASA, M., Innovative Complex Formulation as Topical Treatment for Oral Health Improvment in Periodontal Disease, Rev. Chim., 70(7), 2019, 2485-2490.

Vancouver
Cristache CM, Totu EE, Tanase G, Nechifor AC, Petre D, Burlibasa M. Innovative Complex Formulation as Topical Treatment for Oral Health Improvment in Periodontal Disease. Rev. Chim.[internet]. 2019 Jul;70(7):2485-2490. Available from: https://doi.org/10.37358/RC.19.7.7366

APA 6th edition
Cristache, C.M., Totu, E.E., Tanase, G., Nechifor, A.C., Petre, D. & Burlibasa, M. (2019). Innovative Complex Formulation as Topical Treatment for Oral Health Improvment in Periodontal Disease. Revista de Chimie, 70(7), 2485-2490. https://doi.org/10.37358/RC.19.7.7366

Harvard
Cristache, C.M., Totu, E.E., Tanase, G., Nechifor, A.C., Petre, D., Burlibasa, M. (2019). 'Innovative Complex Formulation as Topical Treatment for Oral Health Improvment in Periodontal Disease', Revista de Chimie, 70(7), pp. 2485-2490. https://doi.org/10.37358/RC.19.7.7366

IEEE
C.M. Cristache, E.E. Totu, G. Tanase, A.C. Nechifor, D. Petre, M. Burlibasa, "Innovative Complex Formulation as Topical Treatment for Oral Health Improvment in Periodontal Disease". Revista de Chimie, vol. 70, no. 7, pp. 2485-2490, 2019. [online]. https://doi.org/10.37358/RC.19.7.7366

Text
Corina Marilena Cristache, Eugenia Eftimie Totu, Gabriela Tanase, Aurelia Cristina Nechifor, Daniel Petre, Mihai Burlibasa,
Innovative Complex Formulation as Topical Treatment for Oral Health Improvment in Periodontal Disease,
Revista de Chimie,
Volume 70, Issue 7,
2019,
Pages 2485-2490,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.7.7366.
(https://revistadechimie.ro/Articles.asp?ID=7366)
Keywords: metronidazole; melatonin; hyaluronic acid; tetracycline; oral health; topical treatment

RIS
TY - JOUR
T1 - Innovative Complex Formulation as Topical Treatment for Oral Health Improvment in Periodontal Disease
A1 - Cristache, Corina Marilena
A2 - Totu, Eugenia Eftimie
A3 - Tanase, Gabriela
A4 - Nechifor, Aurelia Cristina
A5 - Petre, Daniel
A6 - Burlibasa, Mihai
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 7
SP - 2485
EP - 2490
UR - https://doi.org/10.37358/RC.19.7.7366
KW - metronidazole
KW - melatonin
KW - hyaluronic acid
KW - tetracycline
KW - oral health
KW - topical treatment
ER -

BibTex
@article{RevCh2019P2485,
author = {Cristache Corina Marilena and Totu Eugenia Eftimie and Tanase Gabriela and Nechifor Aurelia Cristina and Petre Daniel and Burlibasa Mihai},
title = {Innovative Complex Formulation as Topical Treatment for Oral Health Improvment in Periodontal Disease},
journal = {Revista de Chimie},
volume = {70},
number = {7},
pages = {2485-2490},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.7.7366},
url = {https://revistadechimie.ro/Articles.asp?ID=7366}
}

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