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Revista de Chimie, Volume 70, Issue 7, pp. 2590-2600 (2019)
https://doi.org/10.37358/RC.19.7.7386

Ioana Cristina Tita, Lavinia Lupa, Bogdan Tita, Roxana Liana Stan, Laura Vicas

Compatibility Studies of Valsartan with Different Pharmaceutical Excipients

Abstract:

Compatibility studies between active drugs and excipients are substantial in the pharmaceutical technology. Thermal analysis has been extensively used to obtain information about drug-excipient interactions and to perform pre-formulation studies of pharmaceutical dosage forms. The objective of the present study was to evaluate the compatibility of the valsartan (VALS) with pharmaceutical excipients of common use including diluents, binders, disintegrants, lubricants and solubilising agents. Thermogravimetry (TG), derivative thermogravimetry (DTG), but especially differential scanning calorimetry (DSC) were used for a first screening to find small variations in peak temperature and/or their associated enthalpy for six drug/excipient mixtures (starch, cross caramelose sodique, microcrystalline cellulose 102, povidone K30, lactose monohydrate and magnesium stearate), which indicate some degree of interaction. Additional methods using Fourier transformed infrared spectroscopy (FT-IR) and X-ray powder diffraction (XRPD) confirmed the incompatibility of VALS with starch, povidone K30, lactose monohydrate and magnesium stearate. Those excipients should be avoided in the development of solid dosage forms.
Keywords:
drug-excipient compatibility; valsartan; simultaneous TG/DTG/DSC

Issue: 2019 Volume 70, Number 7
Pages: 2590-2600
https://doi.org/10.37358/RC.19.7.7386
download pdf   Download Pdf Article
Citation Styles
Cite this article as:
TITA, I.C., LUPA, L., TITA, B., STAN, R.L., VICAS, L., Rev.Chim., 70, no. 7, 2019, p. 2590

Vancouver
Tita IC, Lupa L, Tita B, Stan RL, Vicas L. Compatibility Studies of Valsartan with Different Pharmaceutical Excipients. REV.CHIM.[internet]. 2019 Jul;70(7):2590-2600. Available from: https://doi.org/10.37358/RC.19.7.7386


APA 6th edition
Tita, I.C., Lupa, L., Tita, B., Stan, R.L. & Vicas, L. (2019). Compatibility Studies of Valsartan with Different Pharmaceutical Excipients. Revista de Chimie, 70(7), 2590-2600. https://doi.org/10.37358/RC.19.7.7386


Harvard
Tita, I.C., Lupa, L., Tita, B., Stan, R.L., Vicas, L. (2019). 'Compatibility Studies of Valsartan with Different Pharmaceutical Excipients', Revista de Chimie, 70(7), pp. 2590-2600. https://doi.org/10.37358/RC.19.7.7386


IEEE
I.C. Tita, L. Lupa, B. Tita, R.L. Stan, L. Vicas, "Compatibility Studies of Valsartan with Different Pharmaceutical Excipients". Revista de Chimie, vol. 70, no. 7, pp. 2590-2600, 2019. [online]. https://doi.org/10.37358/RC.19.7.7386


Text
Ioana Cristina Tita, Lavinia Lupa, Bogdan Tita, Roxana Liana Stan, Laura Vicas,
Compatibility Studies of Valsartan with Different Pharmaceutical Excipients,
Revista de Chimie,
Volume 70, Issue 7,
2019,
Pages 2590-2600,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.7.7386.
(https://revistadechimie.ro/Articles.asp?ID=7386)
Keywords: drug-excipient compatibility; valsartan; simultaneous TG/DTG/DSC


RIS
TY - JOUR
T1 - Compatibility Studies of Valsartan with Different Pharmaceutical Excipients
A1 - Tita, Ioana Cristina
A2 - Lupa, Lavinia
A3 - Tita, Bogdan
A4 - Stan, Roxana Liana
A5 - Vicas, Laura
JF - Revista de Chimie
JO - Rev.Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 7
SP - 2590
EP - 2600
UR - https://doi.org/10.37358/RC.19.7.7386
KW - drug-excipient compatibility
KW - valsartan
KW - simultaneous TG/DTG/DSC
ER -


BibTex
@article{RevCh2019P2590,
author = {Tita Ioana Cristina and Lupa Lavinia and Tita Bogdan and Stan Roxana Liana and Vicas Laura},
title = {Compatibility Studies of Valsartan with Different Pharmaceutical Excipients},
journal = {Revista de Chimie},
volume = {70},
number = {7},
pages = {2590-2600},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.7.7386},
url = {https://revistadechimie.ro/Articles.asp?ID=7386}
}
 
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