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Revista de Chimie, Volume 70, Issue 7, pp. 2656-2659 (2019)
https://doi.org/10.37358/RC.19.7.7399

Anca Huniadi, Andrea Sorian, Adrian Maghiar, Diana Mocuta, Liana Antal, Ovidiu Laurean Pop, Claudia Teodora Judea Pusta, Camelia Liana Buhas, Andrei Pascalau, Mircea Sandor

6-(2,3-Dichlorodiphenyl)-1,2,4-Triazine-3,5-Diamine Use in Pregnancy and Body Stalk Anomaly- A Possible Association?

Abstract:

Body Stalk Anomaly is a rare malformation syndrome characterized by anterior abdominal wall defect, kyphoscoliosis, limb reduction, rudimentary umbilical cord, craniofacial defects and anomalies of the chest wall. The association between antiepileptic drugs, such as Lamotrigine <6-(2,3-dichlorophenyl)- 1,2,4-triazine-3,5-diamine>, and the development of such malformation have been studied for many years. Many studies can be found regarding the teratogenic potential of Lamotrigine, but they have contradictory results. We present the case of a 34-year old pregnant, caucasian woman, known with acquired epilepsy due to neurocysticercosis for which she is under treatment with Lamotrigine 400mg/day. The patient was examined at 12 weeks of gestational age, when the ultrasound images showed a large defect in the fetal abdominal wall: eviscerated liver and bowel outside the coelomic cavity, kyphoscoliosis, a short umbilical cord, nuchal translucency 2.8mm, mandibular retrognathism. Based upon the aforementioned ultrasound findings we considered the diagnosis to be Body Stalk Anomaly and recommended a medical abortion. Embryological remainings were sent to pathology and genetic department revealing Turner Syndrome. We consider important to detect typical features of the anomaly in the first trimester and distinguish it from other abdominal defects like omphalocele and gastroschisis, since the conditions imply different management. Another important issue is to be aware about the treatment with Lamotrigine.
Keywords:
body stalk anomaly; amniotic band sequence; Turner Syndrome; Lamotrigine

Issue: 2019 Volume 70, Number 7
Pages: 2656-2659
https://doi.org/10.37358/RC.19.7.7399
download pdf   Download Pdf Article
Citation Styles
Cite this article as:
HUNIADI, A., SORIAN, A., MAGHIAR, A., MOCUTA, D., ANTAL, L., POP, O.L., PUSTA, C.T.J., BUHAS, C.L., PASCALAU, A., SANDOR, M., Rev.Chim., 70, no. 7, 2019, p. 2656

Vancouver
Huniadi A, Sorian A, Maghiar A, Mocuta D, Antal L, Pop OL, Pusta CTJ, Buhas CL, Pascalau A, Sandor M. 6-(2,3-Dichlorodiphenyl)-1,2,4-Triazine-3,5-Diamine Use in Pregnancy and Body Stalk Anomaly- A Possible Association?. REV.CHIM.[internet]. 2019 Jul;70(7):2656-2659. Available from: https://doi.org/10.37358/RC.19.7.7399


APA 6th edition
Huniadi, A., Sorian, A., Maghiar, A., Mocuta, D., Antal, L., Pop, O.L.,... Sandor, M. (2019). 6-(2,3-Dichlorodiphenyl)-1,2,4-Triazine-3,5-Diamine Use in Pregnancy and Body Stalk Anomaly- A Possible Association?. Revista de Chimie, 70(7), 2656-2659. https://doi.org/10.37358/RC.19.7.7399


Harvard
Huniadi, A., Sorian, A., Maghiar, A., Mocuta, D., Antal, L., Pop, O.L., Pusta, C.T.J., Buhas, C.L., Pascalau, A., Sandor, M. (2019). '6-(2,3-Dichlorodiphenyl)-1,2,4-Triazine-3,5-Diamine Use in Pregnancy and Body Stalk Anomaly- A Possible Association?', Revista de Chimie, 70(7), pp. 2656-2659. https://doi.org/10.37358/RC.19.7.7399


IEEE
A. Huniadi, A. Sorian, A. Maghiar, D. Mocuta, L. Antal, O.L. Pop, C.T.J. Pusta, C.L. Buhas, A. Pascalau, M. Sandor, "6-(2,3-Dichlorodiphenyl)-1,2,4-Triazine-3,5-Diamine Use in Pregnancy and Body Stalk Anomaly- A Possible Association?". Revista de Chimie, vol. 70, no. 7, pp. 2656-2659, 2019. [online]. https://doi.org/10.37358/RC.19.7.7399


Text
Anca Huniadi, Andrea Sorian, Adrian Maghiar, Diana Mocuta, Liana Antal, Ovidiu Laurean Pop, Claudia Teodora Judea Pusta, Camelia Liana Buhas, Andrei Pascalau, Mircea Sandor,
6-(2,3-Dichlorodiphenyl)-1,2,4-Triazine-3,5-Diamine Use in Pregnancy and Body Stalk Anomaly- A Possible Association?,
Revista de Chimie,
Volume 70, Issue 7,
2019,
Pages 2656-2659,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.7.7399.
(https://revistadechimie.ro/Articles.asp?ID=7399)
Keywords: body stalk anomaly; amniotic band sequence; Turner Syndrome; Lamotrigine


RIS
TY - JOUR
T1 - 6-(2,3-Dichlorodiphenyl)-1,2,4-Triazine-3,5-Diamine Use in Pregnancy and Body Stalk Anomaly- A Possible Association?
A1 - Huniadi, Anca
A2 - Sorian, Andrea
A3 - Maghiar, Adrian
A4 - Mocuta, Diana
A5 - Antal, Liana
A6 - Pop, Ovidiu Laurean
A7 - Pusta, Claudia Teodora Judea
A8 - Buhas, Camelia Liana
A9 - Pascalau, Andrei
A10 - Sandor, Mircea
JF - Revista de Chimie
JO - Rev.Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 7
SP - 2656
EP - 2659
UR - https://doi.org/10.37358/RC.19.7.7399
KW - body stalk anomaly
KW - amniotic band sequence
KW - Turner Syndrome
KW - Lamotrigine
ER -


BibTex
@article{RevCh2019P2656,
author = {Huniadi Anca and Sorian Andrea and Maghiar Adrian and Mocuta Diana and Antal Liana and Pop Ovidiu Laurean and Pusta Claudia Teodora Judea and Buhas Camelia Liana and Pascalau Andrei and Sandor Mircea},
title = {6-(2,3-Dichlorodiphenyl)-1,2,4-Triazine-3,5-Diamine Use in Pregnancy and Body Stalk Anomaly- A Possible Association?},
journal = {Revista de Chimie},
volume = {70},
number = {7},
pages = {2656-2659},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.7.7399},
url = {https://revistadechimie.ro/Articles.asp?ID=7399}
}
 
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