Immune Effects of Transtuzumab in HER2 Positive Breast Cancer

Zgura, Anca; Gales, Laurentia; Haineala, Bogdan; Bratila, Elvira; Mehedintu, Claudia; Barac, Ramona Ileana; Berceanu, Costin; Andreescu, Cristina Veronica; Brinduse, Lacramioara Aurelia; Ionescu, Alec; Anghel, Rodica

Anca Zgura, Laurentia Gales, Bogdan Haineala, Elvira Bratila, Claudia Mehedintu, Ramona Ileana Barac, Costin Berceanu, Cristina Veronica Andreescu, Lacramioara Aurelia Brinduse, Alec Ionescu, Rodica Anghel

Immune Effects of Transtuzumab in HER2 Positive Breast Cancer

Abstract:

The immune system could mediate the antitumor activity of several anticancer treatments. Several chemotherapy compounds, including anthracyclines and oxaliplatin, induce immunogenic cell death that in turn activates the antitumor immune response. Trastuzumab induces antibody-dependant cell-mediated cytotoxicity. On the basis of this background, immune markers have recently been the focus of intense translational research to predict and monitor the efficacy of treatments. Gene expression arrays and immunohistochemistry have assessed immune activation and infiltration by macrophages, natural killer, and T and B lymphocytes. In this paper we present the results of a study that included 22 patients diagnosed with Her2 positive breast cancer undergoing treatment with Transtuzumab.

Keywords:
chemotherapy ; trastuzumab; cytotoxicity; T and B lymphocytes

Issue: 2019, Volume 70, Issue 8

Pages: 2791-2794

Publication date: 2019/9/15

https://doi.org/10.37358/RC.19.8.7428

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
ZGURA, A., GALES, L., HAINEALA, B., BRATILA, E., MEHEDINTU, C., BARAC, R.I., BERCEANU, C., ANDREESCU, C.V., BRINDUSE, L.A., IONESCU, A., ANGHEL, R., Immune Effects of Transtuzumab in HER2 Positive Breast Cancer, Rev. Chim., 70(8), 2019, 2791-2794.

Vancouver
Zgura A, Gales L, Haineala B, Bratila E, Mehedintu C, Barac RI, Berceanu C, Andreescu CV, Brinduse LA, Ionescu A, Anghel R. Immune Effects of Transtuzumab in HER2 Positive Breast Cancer. Rev. Chim.[internet]. 2019 Aug;70(8):2791-2794. Available from: https://doi.org/10.37358/RC.19.8.7428

APA 6th edition
Zgura, A., Gales, L., Haineala, B., Bratila, E., Mehedintu, C., Barac, R.I.,... Anghel, R. (2019). Immune Effects of Transtuzumab in HER2 Positive Breast Cancer. Revista de Chimie, 70(8), 2791-2794. https://doi.org/10.37358/RC.19.8.7428

Harvard
Zgura, A., Gales, L., Haineala, B., Bratila, E., Mehedintu, C., Barac, R.I., Berceanu, C., Andreescu, C.V., Brinduse, L.A., Ionescu, A., Anghel, R. (2019). 'Immune Effects of Transtuzumab in HER2 Positive Breast Cancer', Revista de Chimie, 70(8), pp. 2791-2794. https://doi.org/10.37358/RC.19.8.7428

IEEE
A. Zgura, L. Gales, B. Haineala, E. Bratila, C. Mehedintu, R.I. Barac, C. Berceanu, C.V. Andreescu, L.A. Brinduse, A. Ionescu, R. Anghel, "Immune Effects of Transtuzumab in HER2 Positive Breast Cancer". Revista de Chimie, vol. 70, no. 8, pp. 2791-2794, 2019. [online]. https://doi.org/10.37358/RC.19.8.7428

Text
Anca Zgura, Laurentia Gales, Bogdan Haineala, Elvira Bratila, Claudia Mehedintu, Ramona Ileana Barac, Costin Berceanu, Cristina Veronica Andreescu, Lacramioara Aurelia Brinduse, Alec Ionescu, Rodica Anghel,
Immune Effects of Transtuzumab in HER2 Positive Breast Cancer,
Revista de Chimie,
Volume 70, Issue 8,
2019,
Pages 2791-2794,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.8.7428.
(https://revistadechimie.ro/Articles.asp?ID=7428)
Keywords: chemotherapy ; trastuzumab; cytotoxicity; T and B lymphocytes

RIS
TY - JOUR
T1 - Immune Effects of Transtuzumab in HER2 Positive Breast Cancer
A1 - Zgura, Anca
A2 - Gales, Laurentia
A3 - Haineala, Bogdan
A4 - Bratila, Elvira
A5 - Mehedintu, Claudia
A6 - Barac, Ramona Ileana
A7 - Berceanu, Costin
A8 - Andreescu, Cristina Veronica
A9 - Brinduse, Lacramioara Aurelia
A10 - Ionescu, Alec
A11 - Anghel, Rodica
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 8
SP - 2791
EP - 2794
UR - https://doi.org/10.37358/RC.19.8.7428
KW - chemotherapy
KW - trastuzumab
KW - cytotoxicity
KW - T and B lymphocytes
ER -

BibTex
@article{RevCh2019P2791,
author = {Zgura Anca and Gales Laurentia and Haineala Bogdan and Bratila Elvira and Mehedintu Claudia and Barac Ramona Ileana and Berceanu Costin and Andreescu Cristina Veronica and Brinduse Lacramioara Aurelia and Ionescu Alec and Anghel Rodica},
title = {Immune Effects of Transtuzumab in HER2 Positive Breast Cancer},
journal = {Revista de Chimie},
volume = {70},
number = {8},
pages = {2791-2794},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.8.7428},
url = {https://revistadechimie.ro/Articles.asp?ID=7428}
}

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