Cytotoxic Activity Evaluation on Breast Cells of Guest-host Complexes Containing Artemisinin

Circioban, Denisa; Pavel, Ioana Zinuca; Ledeti, Adriana; Ledeti, Ionut; Danciu, Corina; Dehelean, Cristina

Denisa Circioban, Ioana Zinuca Pavel, Adriana Ledeti, Ionut Ledeti, Corina Danciu, Cristina Dehelean

Cytotoxic Activity Evaluation on Breast Cells of Guest-host Complexes Containing Artemisinin

Abstract:

Artemisinin is a sesquiterpene lactone with vastly proved anti-cancer effects and a low toxicity profile. However, the compound has poor water solubility, bioavailability and a short half-life. As such, the present paper aims to evaluate the cytotoxic effect on breast cells of three guest-host inclusion complexes containing artemisinin as the active compound and different cyclodextrins as hosts. These were tested using two different concentrations (i.e. 12.5 mM and 25 mM) and three cell lines, namely two human breast adenocarcinoma cell lines (MCF7 and MDA-MB-231) and one human non-tumorigenic breast epithelial cell line (MCF10A) employing the colorimetric microculture tetrazolium assay. After a 72h stimulation period, the most promising results were obtained for the complex containing artemisinin and Heptakis(2,3,6-tri-O-methyl)-b-cyclodextrin, the cell viability decrease being significant for the estrogen positive MCF7 cell line (80.0 ± 2.3 %), making the complex a potential candidate for further in vivo testing.

Keywords:
artemisinin; cyclodextrins; breast cancer; cytotoxicity

Issue: 2019, Volume 70, Issue 8

Pages: 2843-2846

Publication date: 2019/9/15

https://doi.org/10.37358/RC.19.8.7439

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
CIRCIOBAN, D., PAVEL, I.Z., LEDETI, A., LEDETI, I., DANCIU, C., DEHELEAN, C., Cytotoxic Activity Evaluation on Breast Cells of Guest-host Complexes Containing Artemisinin, Rev. Chim., 70(8), 2019, 2843-2846.

Vancouver
Circioban D, Pavel IZ, Ledeti A, Ledeti I, Danciu C, Dehelean C. Cytotoxic Activity Evaluation on Breast Cells of Guest-host Complexes Containing Artemisinin. Rev. Chim.[internet]. 2019 Aug;70(8):2843-2846. Available from: https://doi.org/10.37358/RC.19.8.7439

APA 6th edition
Circioban, D., Pavel, I.Z., Ledeti, A., Ledeti, I., Danciu, C. & Dehelean, C. (2019). Cytotoxic Activity Evaluation on Breast Cells of Guest-host Complexes Containing Artemisinin. Revista de Chimie, 70(8), 2843-2846. https://doi.org/10.37358/RC.19.8.7439

Harvard
Circioban, D., Pavel, I.Z., Ledeti, A., Ledeti, I., Danciu, C., Dehelean, C. (2019). 'Cytotoxic Activity Evaluation on Breast Cells of Guest-host Complexes Containing Artemisinin', Revista de Chimie, 70(8), pp. 2843-2846. https://doi.org/10.37358/RC.19.8.7439

IEEE
D. Circioban, I.Z. Pavel, A. Ledeti, I. Ledeti, C. Danciu, C. Dehelean, "Cytotoxic Activity Evaluation on Breast Cells of Guest-host Complexes Containing Artemisinin". Revista de Chimie, vol. 70, no. 8, pp. 2843-2846, 2019. [online]. https://doi.org/10.37358/RC.19.8.7439

Text
Denisa Circioban, Ioana Zinuca Pavel, Adriana Ledeti, Ionut Ledeti, Corina Danciu, Cristina Dehelean,
Cytotoxic Activity Evaluation on Breast Cells of Guest-host Complexes Containing Artemisinin,
Revista de Chimie,
Volume 70, Issue 8,
2019,
Pages 2843-2846,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.8.7439.
(https://revistadechimie.ro/Articles.asp?ID=7439)
Keywords: artemisinin; cyclodextrins; breast cancer; cytotoxicity

RIS
TY - JOUR
T1 - Cytotoxic Activity Evaluation on Breast Cells of Guest-host Complexes Containing Artemisinin
A1 - Circioban, Denisa
A2 - Pavel, Ioana Zinuca
A3 - Ledeti, Adriana
A4 - Ledeti, Ionut
A5 - Danciu, Corina
A6 - Dehelean, Cristina
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 8
SP - 2843
EP - 2846
UR - https://doi.org/10.37358/RC.19.8.7439
KW - artemisinin
KW - cyclodextrins
KW - breast cancer
KW - cytotoxicity
ER -

BibTex
@article{RevCh2019P2843,
author = {Circioban Denisa and Pavel Ioana Zinuca and Ledeti Adriana and Ledeti Ionut and Danciu Corina and Dehelean Cristina},
title = {Cytotoxic Activity Evaluation on Breast Cells of Guest-host Complexes Containing Artemisinin},
journal = {Revista de Chimie},
volume = {70},
number = {8},
pages = {2843-2846},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.8.7439},
url = {https://revistadechimie.ro/Articles.asp?ID=7439}
}

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