Maspin and Ezrina - Biomarker Molecules in Colorectal Cancer Correlative immunohistochemical study

Onofrei, Pavel; Cotrutz, Elena Carmen; Botez, Ana Emanuela; Grecu, Vasile Bogdan; Solcan, Carmen; Sin, Anca Ileana; Dimitriu, Daniela Cristina; Sirbu, Paul Dan; Boiculese, Vasile Lucian; Porumb, Vlad; Stoica, Laura; Olinici, Doinita Temelie

Pavel Onofrei, Elena Carmen Cotrutz, Ana Emanuela Botez, Vasile Bogdan Grecu, Carmen Solcan, Anca Ileana Sin, Daniela Cristina Dimitriu, Paul Dan Sirbu, Vasile Lucian Boiculese, Vlad Porumb, Laura Stoica, Doinita Temelie Olinici

Maspin and Ezrina - Biomarker Molecules in Colorectal Cancer Correlative immunohistochemical study

Abstract:

The results of the recent years researches support the need for personalized therapeutic of cancer by completing the clinical, imagistic and histopathological diagnosis with molecular studies to identify new useful biomarkers for diagnosis, prognosis and tumor progression. Maspin is a non-inhibitory serine protease having a proapoptotic activity, suppressor of tumor invasion, metastasis and angiogenesis. Ezrin is a member of Ezrin/Radixin/Moesin (ERM) family, involved in cellular adhesion mechanisms, motility and invasiveness of tumor cells. In colorectal tumors, there is a heterogeneity of research results regarding the clinical significance of the maspin due to a possible partnership with other molecules with which it interacts through the same signaling pathways. Our study investigated the two molecule‘s immunoreactivity (IR) in 92 colorectal tumors highlighting an inverse correlation between ezrin‘s and maspin‘s expression, suggesting the fact that ezrin‘s overexpression could influence maspin‘s tumoral suppressor role. Furthermore there was observed a difference of the molecules IR within the same tumoral stage, suggesting their utility regarding the treatment protocol of these tumors.

Keywords:
ezrin; maspin; colorectal tumors; biomarkers; correlation

Issue: 2019, Volume 70, Issue 8

Pages: 2926-2933

Publication date: 2019/9/15

https://doi.org/10.37358/RC.19.8.7458

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
ONOFREI, P., COTRUTZ, E.C., BOTEZ, A.E., GRECU, V.B., SOLCAN, C., SIN, A.I., DIMITRIU, D.C., SIRBU, P.D., BOICULESE, V.L., PORUMB, V., STOICA, L., OLINICI, D.T., Maspin and Ezrina - Biomarker Molecules in Colorectal Cancer Correlative immunohistochemical study, Rev. Chim., 70(8), 2019, 2926-2933.

Vancouver
Onofrei P, Cotrutz EC, Botez AE, Grecu VB, Solcan C, Sin AI, Dimitriu DC, Sirbu PD, Boiculese VL, Porumb V, Stoica L, Olinici DT. Maspin and Ezrina - Biomarker Molecules in Colorectal Cancer Correlative immunohistochemical study. Rev. Chim.[internet]. 2019 Aug;70(8):2926-2933. Available from: https://doi.org/10.37358/RC.19.8.7458

APA 6th edition
Onofrei, P., Cotrutz, E.C., Botez, A.E., Grecu, V.B., Solcan, C., Sin, A.I.,... Olinici, D.T. (2019). Maspin and Ezrina - Biomarker Molecules in Colorectal Cancer Correlative immunohistochemical study. Revista de Chimie, 70(8), 2926-2933. https://doi.org/10.37358/RC.19.8.7458

Harvard
Onofrei, P., Cotrutz, E.C., Botez, A.E., Grecu, V.B., Solcan, C., Sin, A.I., Dimitriu, D.C., Sirbu, P.D., Boiculese, V.L., Porumb, V., Stoica, L., Olinici, D.T. (2019). 'Maspin and Ezrina - Biomarker Molecules in Colorectal Cancer Correlative immunohistochemical study', Revista de Chimie, 70(8), pp. 2926-2933. https://doi.org/10.37358/RC.19.8.7458

IEEE
P. Onofrei, E.C. Cotrutz, A.E. Botez, V.B. Grecu, C. Solcan, A.I. Sin, D.C. Dimitriu, P.D. Sirbu, V.L. Boiculese, V. Porumb, L. Stoica, D.T. Olinici, "Maspin and Ezrina - Biomarker Molecules in Colorectal Cancer Correlative immunohistochemical study". Revista de Chimie, vol. 70, no. 8, pp. 2926-2933, 2019. [online]. https://doi.org/10.37358/RC.19.8.7458

Text
Pavel Onofrei, Elena Carmen Cotrutz, Ana Emanuela Botez, Vasile Bogdan Grecu, Carmen Solcan, Anca Ileana Sin, Daniela Cristina Dimitriu, Paul Dan Sirbu, Vasile Lucian Boiculese, Vlad Porumb, Laura Stoica, Doinita Temelie Olinici,
Maspin and Ezrina - Biomarker Molecules in Colorectal Cancer Correlative immunohistochemical study,
Revista de Chimie,
Volume 70, Issue 8,
2019,
Pages 2926-2933,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.8.7458.
(https://revistadechimie.ro/Articles.asp?ID=7458)
Keywords: ezrin; maspin; colorectal tumors; biomarkers; correlation

RIS
TY - JOUR
T1 - Maspin and Ezrina - Biomarker Molecules in Colorectal Cancer Correlative immunohistochemical study
A1 - Onofrei, Pavel
A2 - Cotrutz, Elena Carmen
A3 - Botez, Ana Emanuela
A4 - Grecu, Vasile Bogdan
A5 - Solcan, Carmen
A6 - Sin, Anca Ileana
A7 - Dimitriu, Daniela Cristina
A8 - Sirbu, Paul Dan
A9 - Boiculese, Vasile Lucian
A10 - Porumb, Vlad
A11 - Stoica, Laura
A12 - Olinici, Doinita Temelie
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 8
SP - 2926
EP - 2933
UR - https://doi.org/10.37358/RC.19.8.7458
KW - ezrin
KW - maspin
KW - colorectal tumors
KW - biomarkers
KW - correlation
ER -

BibTex
@article{RevCh2019P2926,
author = {Onofrei Pavel and Cotrutz Elena Carmen and Botez Ana Emanuela and Grecu Vasile Bogdan and Solcan Carmen and Sin Anca Ileana and Dimitriu Daniela Cristina and Sirbu Paul Dan and Boiculese Vasile Lucian and Porumb Vlad and Stoica Laura and Olinici Doinita Temelie},
title = {Maspin and Ezrina - Biomarker Molecules in Colorectal Cancer Correlative immunohistochemical study},
journal = {Revista de Chimie},
volume = {70},
number = {8},
pages = {2926-2933},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.8.7458},
url = {https://revistadechimie.ro/Articles.asp?ID=7458}
}

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