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REVISTA DE CHIMIE
Cite as: Rev. Chim.
https://doi.org/10.37358/Rev.Chim.1949

OSIM Nr. R102355
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Revista de Chimie (Rev. Chim.), Year 2019, Volume 70, Issue 8, 3017-3020

https://doi.org/10.37358/RC.19.8.7477

Despina Calamar Popovici, Ioana Ionita, Mirela Nedelcu, Claudiu Ionita, Hortensia Ionita, Radu Dumitru Moleriu, Calin Ovidiu Ilie, Daniela Iacob, Luca Tudor Constantin, Adelina Cheveresan, Delia Berceanu Vaduva, Daniela Radu

Complications of Tyrosine Kinase Inhibitors Therapy in Chronic Myeloid Leukemia - Chronic Phase

Abstract:

Chronic myeloid leukaemia is a malignant tumor of pluripotent haemopoetic stem cell, characterized by increase granulocytes with left shift and the presence of the Ph chromosome.Treatment of chronic phase is made with tyrosine kinase inhibitors administered orally and can have secondary effects: haematological and non-haematological. The purpose of this paper is to assess complications of tyrosine kinase inhibitor therapy in chronic phase of chronic myeloid leukemia and establishing correlations with the type of inhibitor used. The study was performed on a total of 140 patients diagnosed with chronic phase CML in the Hematology Department of the City Clinical Emergency Hospital Timisoara between January 2006 - January 2016. The lot proposed has been studied in terms of anthropometric parameters and also the haematological and biochemical. It showed complications after initiation of therapy with tyrosine kinase inhibitors and also the correlations statistically significant between complications and type of inhibitor used. The study reveals that regardless the type of inhibitor used both haematological complications arise and non haematological. The most common are: neutropenia, thrombocytopenia, anemia, fluid retention, muscle and joint pain. Less common are nausea, diarrhea, abdominal pain, increased liver enzymes. Despite complications of occurring, these modern therapies significantly improve both survival and quality of life of patients.
Keywords:
chronic myeloid leukemia; tyrosine kinase inhibitors; treatment; complications

Issue: 2019, Volume 70, Issue 8
Pages: 3017-3020
Publication date: 2019/9/15
https://doi.org/10.37358/RC.19.8.7477
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
POPOVICI, D.C., IONITA, I., NEDELCU, M., IONITA, C., IONITA, H., MOLERIU, R.D., ILIE, C.O., IACOB, D., CONSTANTIN, L.T., CHEVERESAN, A., VADUVA, D.B., RADU, D., Complications of Tyrosine Kinase Inhibitors Therapy in Chronic Myeloid Leukemia - Chronic Phase, Rev. Chim., 70(8), 2019, 3017-3020.

Vancouver
Popovici DC, Ionita I, Nedelcu M, Ionita C, Ionita H, Moleriu RD, Ilie CO, Iacob D, Constantin LT, Cheveresan A, Vaduva DB, Radu D. Complications of Tyrosine Kinase Inhibitors Therapy in Chronic Myeloid Leukemia - Chronic Phase. Rev. Chim.[internet]. 2019 Aug;70(8):3017-3020. Available from: https://doi.org/10.37358/RC.19.8.7477


APA 6th edition
Popovici, D.C., Ionita, I., Nedelcu, M., Ionita, C., Ionita, H., Moleriu, R.D.,... Radu, D. (2019). Complications of Tyrosine Kinase Inhibitors Therapy in Chronic Myeloid Leukemia - Chronic Phase. Revista de Chimie, 70(8), 3017-3020. https://doi.org/10.37358/RC.19.8.7477


Harvard
Popovici, D.C., Ionita, I., Nedelcu, M., Ionita, C., Ionita, H., Moleriu, R.D., Ilie, C.O., Iacob, D., Constantin, L.T., Cheveresan, A., Vaduva, D.B., Radu, D. (2019). 'Complications of Tyrosine Kinase Inhibitors Therapy in Chronic Myeloid Leukemia - Chronic Phase', Revista de Chimie, 70(8), pp. 3017-3020. https://doi.org/10.37358/RC.19.8.7477


IEEE
D.C. Popovici, I. Ionita, M. Nedelcu, C. Ionita, H. Ionita, R.D. Moleriu, C.O. Ilie, D. Iacob, L.T. Constantin, A. Cheveresan, D.B. Vaduva, D. Radu, "Complications of Tyrosine Kinase Inhibitors Therapy in Chronic Myeloid Leukemia - Chronic Phase". Revista de Chimie, vol. 70, no. 8, pp. 3017-3020, 2019. [online]. https://doi.org/10.37358/RC.19.8.7477


Text
Despina Calamar Popovici, Ioana Ionita, Mirela Nedelcu, Claudiu Ionita, Hortensia Ionita, Radu Dumitru Moleriu, Calin Ovidiu Ilie, Daniela Iacob, Luca Tudor Constantin, Adelina Cheveresan, Delia Berceanu Vaduva, Daniela Radu,
Complications of Tyrosine Kinase Inhibitors Therapy in Chronic Myeloid Leukemia - Chronic Phase,
Revista de Chimie,
Volume 70, Issue 8,
2019,
Pages 3017-3020,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.8.7477.
(https://revistadechimie.ro/Articles.asp?ID=7477)
Keywords: chronic myeloid leukemia; tyrosine kinase inhibitors; treatment; complications


RIS
TY - JOUR
T1 - Complications of Tyrosine Kinase Inhibitors Therapy in Chronic Myeloid Leukemia - Chronic Phase
A1 - Popovici, Despina Calamar
A2 - Ionita, Ioana
A3 - Nedelcu, Mirela
A4 - Ionita, Claudiu
A5 - Ionita, Hortensia
A6 - Moleriu, Radu Dumitru
A7 - Ilie, Calin Ovidiu
A8 - Iacob, Daniela
A9 - Constantin, Luca Tudor
A10 - Cheveresan, Adelina
A11 - Vaduva, Delia Berceanu
A12 - Radu, Daniela
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 8
SP - 3017
EP - 3020
UR - https://doi.org/10.37358/RC.19.8.7477
KW - chronic myeloid leukemia
KW - tyrosine kinase inhibitors
KW - treatment
KW - complications
ER -


BibTex
@article{RevCh2019P3017,
author = {Popovici Despina Calamar and Ionita Ioana and Nedelcu Mirela and Ionita Claudiu and Ionita Hortensia and Moleriu Radu Dumitru and Ilie Calin Ovidiu and Iacob Daniela and Constantin Luca Tudor and Cheveresan Adelina and Vaduva Delia Berceanu and Radu Daniela},
title = {Complications of Tyrosine Kinase Inhibitors Therapy in Chronic Myeloid Leukemia - Chronic Phase},
journal = {Revista de Chimie},
volume = {70},
number = {8},
pages = {3017-3020},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.8.7477},
url = {https://revistadechimie.ro/Articles.asp?ID=7477}
}
 
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