Evaluating the Efficacy of the Treatment with Benfotiamine and Alpha-lipoic Acid in Distal Symmetric Painful Diabetic Polyneuropathy

Popa, Amorin Remus; Bungau, Simona; Vesa, Cosmin Mihai; Bondar, Andrei Cristian; Pantis, Carmen; Maghiar, Octavian; Dimulescu (Nica), Ioana Alina; Cseppento, Delia Carmen Nistor; Rus, Marius

Amorin Remus Popa, Simona Bungau, Cosmin Mihai Vesa, Andrei Cristian Bondar, Carmen Pantis, Octavian Maghiar, Ioana Alina Dimulescu (Nica), Delia Carmen Nistor Cseppento, Marius Rus

Evaluating the Efficacy of the Treatment with Benfotiamine and Alpha-lipoic Acid in Distal Symmetric Painful Diabetic Polyneuropathy

Abstract:

Distal symmetric painful diabetic neuropathy is the most frequent clinical form of diabetic neuropathy. The condition appears as a result of alteration of the structure and function of nervous fibres as a consequence of hyperglycaemia. Hyperglycaemia determines the metabolism of glucose on alterative pathways and generates increased oxidative stress, mechanisms that cause an accelerated apoptosis of the neurons and a high intensity of lipid peroxidation. Pathogenic treatment of diabetic neuropathy includes limited options, two of them are: Benfotiamine (inhibits the metabolism of glucose on hexosamine pathway, reducing the formation of advanced glycosylation end products) and alpha-lipoic acid (has a scavenger effect on free radical species). The study included 120 patients with distal symmetric painful diabetic neuropathy randomized in 3 treatment groups. We evaluated the effect of oral administration for 8 weeks of Benfotiamine in a dosage of 300mg/day in monotherapy, of alpha-lipoic acid in a dosage of 600 mg/day in monotherapy, respectively of both -in combined therapy - on the parameters that are used to determine the severity of distal symmetric painful diabetic neuropathy: Diabetic Neuropathy Symptoms score, Neuropathy Disability Score and the intensity of lower limb pain on the visual analogue pain scale. All the three therapies were effective with a statistically significant improvement of these parameters, but the combined therapy with alpha-lipoic acid and Benfotiamine was superior to the monotherapy with alpha-lipoic acid or Benfotiamine.

Keywords:
pathogenic treatment of diabetic neuropathy; Diabetic Neuropathy Symptoms score; Neuropathy Disability Score; alpha-lipoic acid; Benfotiamine

Issue: 2019, Volume 70, Issue 9

Pages: 3108-3114

Publication date: 2019/10/15

https://doi.org/10.37358/RC.19.9.7498

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
POPA, A.R., BUNGAU, S., VESA, C.M., BONDAR, A.C., PANTIS, C., MAGHIAR, O., DIMULESCU (NICA), I.A., CSEPPENTO, D.C.N., RUS, M., Evaluating the Efficacy of the Treatment with Benfotiamine and Alpha-lipoic Acid in Distal Symmetric Painful Diabetic Polyneuropathy, Rev. Chim., 70(9), 2019, 3108-3114.

Vancouver
Popa AR, Bungau S, Vesa CM, Bondar AC, Pantis C, Maghiar O, Dimulescu (Nica) IA, Cseppento DCN, Rus M. Evaluating the Efficacy of the Treatment with Benfotiamine and Alpha-lipoic Acid in Distal Symmetric Painful Diabetic Polyneuropathy. Rev. Chim.[internet]. 2019 Sep;70(9):3108-3114. Available from: https://doi.org/10.37358/RC.19.9.7498

APA 6th edition
Popa, A.R., Bungau, S., Vesa, C.M., Bondar, A.C., Pantis, C., Maghiar, O.,... Rus, M. (2019). Evaluating the Efficacy of the Treatment with Benfotiamine and Alpha-lipoic Acid in Distal Symmetric Painful Diabetic Polyneuropathy. Revista de Chimie, 70(9), 3108-3114. https://doi.org/10.37358/RC.19.9.7498

Harvard
Popa, A.R., Bungau, S., Vesa, C.M., Bondar, A.C., Pantis, C., Maghiar, O., Dimulescu (Nica), I.A., Cseppento, D.C.N., Rus, M. (2019). 'Evaluating the Efficacy of the Treatment with Benfotiamine and Alpha-lipoic Acid in Distal Symmetric Painful Diabetic Polyneuropathy', Revista de Chimie, 70(9), pp. 3108-3114. https://doi.org/10.37358/RC.19.9.7498

IEEE
A.R. Popa, S. Bungau, C.M. Vesa, A.C. Bondar, C. Pantis, O. Maghiar, I.A. Dimulescu(Nica), D.C.N. Cseppento, M. Rus, "Evaluating the Efficacy of the Treatment with Benfotiamine and Alpha-lipoic Acid in Distal Symmetric Painful Diabetic Polyneuropathy". Revista de Chimie, vol. 70, no. 9, pp. 3108-3114, 2019. [online]. https://doi.org/10.37358/RC.19.9.7498

Text
Amorin Remus Popa, Simona Bungau, Cosmin Mihai Vesa, Andrei Cristian Bondar, Carmen Pantis, Octavian Maghiar, Ioana Alina Dimulescu(Nica), Delia Carmen Nistor Cseppento, Marius Rus,
Evaluating the Efficacy of the Treatment with Benfotiamine and Alpha-lipoic Acid in Distal Symmetric Painful Diabetic Polyneuropathy,
Revista de Chimie,
Volume 70, Issue 9,
2019,
Pages 3108-3114,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.9.7498.
(https://revistadechimie.ro/Articles.asp?ID=7498)
Keywords: pathogenic treatment of diabetic neuropathy; Diabetic Neuropathy Symptoms score; Neuropathy Disability Score; alpha-lipoic acid; Benfotiamine

RIS
TY - JOUR
T1 - Evaluating the Efficacy of the Treatment with Benfotiamine and Alpha-lipoic Acid in Distal Symmetric Painful Diabetic Polyneuropathy
A1 - Popa, Amorin Remus
A2 - Bungau, Simona
A3 - Vesa, Cosmin Mihai
A4 - Bondar, Andrei Cristian
A5 - Pantis, Carmen
A6 - Maghiar, Octavian
A7 - Dimulescu (Nica), Ioana Alina
A8 - Cseppento, Delia Carmen Nistor
A9 - Rus, Marius
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 9
SP - 3108
EP - 3114
UR - https://doi.org/10.37358/RC.19.9.7498
KW - pathogenic treatment of diabetic neuropathy
KW - Diabetic Neuropathy Symptoms score
KW - Neuropathy Disability Score
KW - alpha-lipoic acid
KW - Benfotiamine
ER -

BibTex
@article{RevCh2019P3108,
author = {Popa Amorin Remus and Bungau Simona and Vesa Cosmin Mihai and Bondar Andrei Cristian and Pantis Carmen and Maghiar Octavian and Dimulescu (Nica) Ioana Alina and Cseppento Delia Carmen Nistor and Rus Marius},
title = {Evaluating the Efficacy of the Treatment with Benfotiamine and Alpha-lipoic Acid in Distal Symmetric Painful Diabetic Polyneuropathy},
journal = {Revista de Chimie},
volume = {70},
number = {9},
pages = {3108-3114},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.9.7498},
url = {https://revistadechimie.ro/Articles.asp?ID=7498}
}

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