Oxidative Stress and BCR-ABL1 Transcript Levels in Chronic Myeloid Leukemia: an Intricate Relationship

Pascu, Emilia Georgiana; Gaman, Mihnea Alexandru; Moisa, Cornel; Gaman, Amelia Maria

Emilia Georgiana Pascu, Mihnea Alexandru Gaman, Cornel Moisa, Amelia Maria Gaman

Oxidative Stress and BCR-ABL1 Transcript Levels in Chronic Myeloid Leukemia: an Intricate Relationship

Abstract:

Chronic myeloid leukemia (CML) is a chronic myeloproliferative neoplasm characterized by the presence of the Philadelphia chromosome. Oxidative stress is involved in CML etiopathogenesis and disease progression, as well as the response to tyrosine kinase inhibitors (TKI) treatment. We evaluated oxidative stress levels in 47 CML patients vs. controls. The total antioxidant capacity (TAC) was measured using a FLUOstar Omega microplate reader (reagents from Sigma-Aldrich). Cellular reactive oxygen species (ROS) were evaluated using a CyFlow SPACE Sysmex flow-cytometer (reagents from Abcam). Oxidative stress levels were higher in CML patients vs. controls. The maximum TAC value and the minimum ROS value were recorded in CML patients with a BCR-ABL1 transcript value of 0.1-1%, suggesting that the production of plasma antioxidants progressively increases as a compensatory mechanism in CML patients undergoing TKI treatment in order to annihilate ROS. The pseudonormalization of the cell redox status observed in these patients could be an alarm signal prior to the development of resistance to TKI treatment or disease progression.

Keywords:
oxidative stress; chronic myeloid leukaemia; tyrosine kinase inhibitors; BCR-ABL1 transcript

Issue: 2019, Volume 70, Issue 9

Pages: 3193-3196

Publication date: 2019/10/15

https://doi.org/10.37358/RC.19.9.7514

Download Pdf Article

This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
PASCU, E.G., GAMAN, M.A., MOISA, C., GAMAN, A.M., Oxidative Stress and BCR-ABL1 Transcript Levels in Chronic Myeloid Leukemia: an Intricate Relationship, Rev. Chim., 70(9), 2019, 3193-3196.

Vancouver
Pascu EG, Gaman MA, Moisa C, Gaman AM. Oxidative Stress and BCR-ABL1 Transcript Levels in Chronic Myeloid Leukemia: an Intricate Relationship. Rev. Chim.[internet]. 2019 Sep;70(9):3193-3196. Available from: https://doi.org/10.37358/RC.19.9.7514

APA 6th edition
Pascu, E.G., Gaman, M.A., Moisa, C. & Gaman, A.M. (2019). Oxidative Stress and BCR-ABL1 Transcript Levels in Chronic Myeloid Leukemia: an Intricate Relationship. Revista de Chimie, 70(9), 3193-3196. https://doi.org/10.37358/RC.19.9.7514

Harvard
Pascu, E.G., Gaman, M.A., Moisa, C., Gaman, A.M. (2019). 'Oxidative Stress and BCR-ABL1 Transcript Levels in Chronic Myeloid Leukemia: an Intricate Relationship', Revista de Chimie, 70(9), pp. 3193-3196. https://doi.org/10.37358/RC.19.9.7514

IEEE
E.G. Pascu, M.A. Gaman, C. Moisa, A.M. Gaman, "Oxidative Stress and BCR-ABL1 Transcript Levels in Chronic Myeloid Leukemia: an Intricate Relationship". Revista de Chimie, vol. 70, no. 9, pp. 3193-3196, 2019. [online]. https://doi.org/10.37358/RC.19.9.7514

Text
Emilia Georgiana Pascu, Mihnea Alexandru Gaman, Cornel Moisa, Amelia Maria Gaman,
Oxidative Stress and BCR-ABL1 Transcript Levels in Chronic Myeloid Leukemia: an Intricate Relationship,
Revista de Chimie,
Volume 70, Issue 9,
2019,
Pages 3193-3196,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.9.7514.
(https://revistadechimie.ro/Articles.asp?ID=7514)
Keywords: oxidative stress; chronic myeloid leukaemia; tyrosine kinase inhibitors; BCR-ABL1 transcript

RIS
TY - JOUR
T1 - Oxidative Stress and BCR-ABL1 Transcript Levels in Chronic Myeloid Leukemia: an Intricate Relationship
A1 - Pascu, Emilia Georgiana
A2 - Gaman, Mihnea Alexandru
A3 - Moisa, Cornel
A4 - Gaman, Amelia Maria
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 9
SP - 3193
EP - 3196
UR - https://doi.org/10.37358/RC.19.9.7514
KW - oxidative stress
KW - chronic myeloid leukaemia
KW - tyrosine kinase inhibitors
KW - BCR-ABL1 transcript
ER -

BibTex
@article{RevCh2019P3193,
author = {Pascu Emilia Georgiana and Gaman Mihnea Alexandru and Moisa Cornel and Gaman Amelia Maria},
title = {Oxidative Stress and BCR-ABL1 Transcript Levels in Chronic Myeloid Leukemia: an Intricate Relationship},
journal = {Revista de Chimie},
volume = {70},
number = {9},
pages = {3193-3196},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.9.7514},
url = {https://revistadechimie.ro/Articles.asp?ID=7514}
}

<<<< back

PUBLISHING SECTION

Author Guidelines

* Paper Drafting

* Paper Template

* Ethical Statement

* Paper Submission

Ghidul Autorului (ro)

Open Access & Archiving Policy

Search Authors

LATEST NEWS
	NUMAR OMAGIAL PETRU PONI.. detalii
	Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
	English-Romanian Dictionary for Mechanical Engineering (download pdf)