Merkel Cell Carcinoma - A Rare Form of Skin Cancer with New Therapeutic Options

Stanculeanu, Dana Lucia; Toma, Oana; Vasile, Cristian; Nitipir, Cornelia; Bodilcu, Alina; Mihaila, Raluca; Hainarosie, Razvan; Stefanescu, Cristian Dragos; Zob, Daniela

Dana Lucia Stanculeanu, Oana Toma, Cristian Vasile, Cornelia Nitipir, Alina Bodilcu, Raluca Mihaila, Razvan Hainarosie, Cristian Dragos Stefanescu, Daniela Zob

Merkel Cell Carcinoma - A Rare Form of Skin Cancer with New Therapeutic Options

Abstract:

Merkel cell carcinoma (MCC) is a rare primary neuroendocrine carcinoma of the skin, with very aggressive behavior. Etiological factors contributing to MCC development, include exposure to UV radiation, infection with Merkel cell polyomavirus (MCPyV) and chronic immunosuppression. It is commonly found in regions of the body that are exposed to sun -55% of cases are located in the head and neck. The 5 years survival rate for metastatic disease is approximately 25%. The estimated mortality rate for MCC is between 33% and 46%. Therapeutic options for MCC depends on disease characteristics (stage of disease at presentation, location of the tumor, regional lymph node involvement, comorbidities and performance status of the patient) and it includes multimodal treatments like surgery, chemotherapy and emerging immunotherapeutic treatments with early promising results. Our clinic experience is very limited with this type of malignancy, only three cases were diagnosed and treated in our department, but with encouraging results regarding the newest immunotherapeutic options, with good quality of life and results similar with the data from the literature.

Keywords:
Merkel cell carcinoma; cutaneous neuroendocrine carcinoma; immunohistochemistry; multimodal treatment; immunotherapy

Issue: 2019, Volume 70, Issue 9

Pages: 3245-3249

Publication date: 2019/10/15

https://doi.org/10.37358/RC.19.9.7527

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
STANCULEANU, D.L., TOMA, O., VASILE, C., NITIPIR, C., BODILCU, A., MIHAILA, R., HAINAROSIE, R., STEFANESCU, C.D., ZOB, D., Merkel Cell Carcinoma - A Rare Form of Skin Cancer with New Therapeutic Options, Rev. Chim., 70(9), 2019, 3245-3249.

Vancouver
Stanculeanu DL, Toma O, Vasile C, Nitipir C, Bodilcu A, Mihaila R, Hainarosie R, Stefanescu CD, Zob D. Merkel Cell Carcinoma - A Rare Form of Skin Cancer with New Therapeutic Options. Rev. Chim.[internet]. 2019 Sep;70(9):3245-3249. Available from: https://doi.org/10.37358/RC.19.9.7527

APA 6th edition
Stanculeanu, D.L., Toma, O., Vasile, C., Nitipir, C., Bodilcu, A., Mihaila, R.,... Zob, D. (2019). Merkel Cell Carcinoma - A Rare Form of Skin Cancer with New Therapeutic Options. Revista de Chimie, 70(9), 3245-3249. https://doi.org/10.37358/RC.19.9.7527

Harvard
Stanculeanu, D.L., Toma, O., Vasile, C., Nitipir, C., Bodilcu, A., Mihaila, R., Hainarosie, R., Stefanescu, C.D., Zob, D. (2019). 'Merkel Cell Carcinoma - A Rare Form of Skin Cancer with New Therapeutic Options', Revista de Chimie, 70(9), pp. 3245-3249. https://doi.org/10.37358/RC.19.9.7527

IEEE
D.L. Stanculeanu, O. Toma, C. Vasile, C. Nitipir, A. Bodilcu, R. Mihaila, R. Hainarosie, C.D. Stefanescu, D. Zob, "Merkel Cell Carcinoma - A Rare Form of Skin Cancer with New Therapeutic Options". Revista de Chimie, vol. 70, no. 9, pp. 3245-3249, 2019. [online]. https://doi.org/10.37358/RC.19.9.7527

Text
Dana Lucia Stanculeanu, Oana Toma, Cristian Vasile, Cornelia Nitipir, Alina Bodilcu, Raluca Mihaila, Razvan Hainarosie, Cristian Dragos Stefanescu, Daniela Zob,
Merkel Cell Carcinoma - A Rare Form of Skin Cancer with New Therapeutic Options,
Revista de Chimie,
Volume 70, Issue 9,
2019,
Pages 3245-3249,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.9.7527.
(https://revistadechimie.ro/Articles.asp?ID=7527)
Keywords: Merkel cell carcinoma; cutaneous neuroendocrine carcinoma; immunohistochemistry; multimodal treatment; immunotherapy

RIS
TY - JOUR
T1 - Merkel Cell Carcinoma - A Rare Form of Skin Cancer with New Therapeutic Options
A1 - Stanculeanu, Dana Lucia
A2 - Toma, Oana
A3 - Vasile, Cristian
A4 - Nitipir, Cornelia
A5 - Bodilcu, Alina
A6 - Mihaila, Raluca
A7 - Hainarosie, Razvan
A8 - Stefanescu, Cristian Dragos
A9 - Zob, Daniela
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 9
SP - 3245
EP - 3249
UR - https://doi.org/10.37358/RC.19.9.7527
KW - Merkel cell carcinoma
KW - cutaneous neuroendocrine carcinoma
KW - immunohistochemistry
KW - multimodal treatment
KW - immunotherapy
ER -

BibTex
@article{RevCh2019P3245,
author = {Stanculeanu Dana Lucia and Toma Oana and Vasile Cristian and Nitipir Cornelia and Bodilcu Alina and Mihaila Raluca and Hainarosie Razvan and Stefanescu Cristian Dragos and Zob Daniela},
title = {Merkel Cell Carcinoma - A Rare Form of Skin Cancer with New Therapeutic Options},
journal = {Revista de Chimie},
volume = {70},
number = {9},
pages = {3245-3249},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.9.7527},
url = {https://revistadechimie.ro/Articles.asp?ID=7527}
}

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