Tipurile de vase asociate tumorilor GIST influenteaza eficienta terapiei antivasculare cu inhibitori de receptor tirozin-kinazic

Korodi, Andrei Dan; Furau, Cristian; Furau, Gheorghe; Dimitriu, Mihai; Socea, Bogdan; Codreanu, Ada Maria; Botezatu, Dragos; Dumnici, Alexandru; Totolici, Bogdan; Barbu, Ion; Gheorghiu, Nicolae; Gheorghiu, Diana Claudia; Miutescu, Eftimie

Andrei Dan Korodi, Cristian Furau, Gheorghe Furau, Mihai Dimitriu, Bogdan Socea, Ada Maria Codreanu, Dragos Botezatu, Alexandru Dumnici, Bogdan Totolici, Ion Barbu, Nicolae Gheorghiu, Diana Claudia Gheorghiu, Eftimie Miutescu

Tipurile de vase asociate tumorilor GIST influenteaza eficienta terapiei antivasculare cu inhibitori de receptor tirozin-kinazic

Abstract:

Gastrointestinal stromal tumors (GIST’sare the most common mesenchymal neoplasms of the alimentary tract. Angiogenesis is an essential condition in the growth and development of tumors, especially in the case of GISTs due to their particular behavior. The aggressive behavior depends on the size and site of the tumor in close relationship with the intratumoral vascular development. The purpose of this study is to investigate, using immunohistochemical stainings, the types of intratumoral vessels in GIST’s, knowing the interrelation between the tumor angiogenesis and the response to the targeted antivascular therapy, influencing directly the prognosis. In our research, in all 37 cases the most numerous vessels were the immature and intermediate ones, signaling an increased angiogenic activity. The perivascular cell free vessels are the most sensitive at antivascular therapy with tyrosine kinase receptor inhibitors, providing a good response and prognosis to the treatment. Immature vessels evaluation especially, could be a an important sign in assessment of the effectiveness of antivascular therapy in GIST.

Keywords:
types of vessels; GIST; anti-vascular therapy; tyrosine kinase receptor inhibitor

Issue: 2019, Volume 70, Issue 9

Pages: 3250-3253

Publication date: 2019/10/15

https://doi.org/10.37358/RC.19.9.7528

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
KORODI, A.D., FURAU, C., FURAU, G., DIMITRIU, M., SOCEA, B., CODREANU, A.M., BOTEZATU, D., DUMNICI, A., TOTOLICI, B., BARBU, I., GHEORGHIU, N., GHEORGHIU, D.C., MIUTESCU, E., Tipurile de vase asociate tumorilor GIST influenteaza eficienta terapiei antivasculare cu inhibitori de receptor tirozin-kinazic, Rev. Chim., 70(9), 2019, 3250-3253.

Vancouver
Korodi AD, Furau C, Furau G, Dimitriu M, Socea B, Codreanu AM, Botezatu D, Dumnici A, Totolici B, Barbu I, Gheorghiu N, Gheorghiu DC, Miutescu E. Tipurile de vase asociate tumorilor GIST influenteaza eficienta terapiei antivasculare cu inhibitori de receptor tirozin-kinazic. Rev. Chim.[internet]. 2019 Sep;70(9):3250-3253. Available from: https://doi.org/10.37358/RC.19.9.7528

APA 6th edition
Korodi, A.D., Furau, C., Furau, G., Dimitriu, M., Socea, B., Codreanu, A.M.,... Miutescu, E. (2019). Tipurile de vase asociate tumorilor GIST influenteaza eficienta terapiei antivasculare cu inhibitori de receptor tirozin-kinazic. Revista de Chimie, 70(9), 3250-3253. https://doi.org/10.37358/RC.19.9.7528

Harvard
Korodi, A.D., Furau, C., Furau, G., Dimitriu, M., Socea, B., Codreanu, A.M., Botezatu, D., Dumnici, A., Totolici, B., Barbu, I., Gheorghiu, N., Gheorghiu, D.C., Miutescu, E. (2019). 'Tipurile de vase asociate tumorilor GIST influenteaza eficienta terapiei antivasculare cu inhibitori de receptor tirozin-kinazic', Revista de Chimie, 70(9), pp. 3250-3253. https://doi.org/10.37358/RC.19.9.7528

IEEE
A.D. Korodi, C. Furau, G. Furau, M. Dimitriu, B. Socea, A.M. Codreanu, D. Botezatu, A. Dumnici, B. Totolici, I. Barbu, N. Gheorghiu, D.C. Gheorghiu, E. Miutescu, "Tipurile de vase asociate tumorilor GIST influenteaza eficienta terapiei antivasculare cu inhibitori de receptor tirozin-kinazic". Revista de Chimie, vol. 70, no. 9, pp. 3250-3253, 2019. [online]. https://doi.org/10.37358/RC.19.9.7528

Text
Andrei Dan Korodi, Cristian Furau, Gheorghe Furau, Mihai Dimitriu, Bogdan Socea, Ada Maria Codreanu, Dragos Botezatu, Alexandru Dumnici, Bogdan Totolici, Ion Barbu, Nicolae Gheorghiu, Diana Claudia Gheorghiu, Eftimie Miutescu,
Tipurile de vase asociate tumorilor GIST influenteaza eficienta terapiei antivasculare cu inhibitori de receptor tirozin-kinazic,
Revista de Chimie,
Volume 70, Issue 9,
2019,
Pages 3250-3253,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.9.7528.
(https://revistadechimie.ro/Articles.asp?ID=7528)
Keywords: types of vessels; GIST; anti-vascular therapy; tyrosine kinase receptor inhibitor

RIS
TY - JOUR
T1 - Tipurile de vase asociate tumorilor GIST influenteaza eficienta terapiei antivasculare cu inhibitori de receptor tirozin-kinazic
A1 - Korodi, Andrei Dan
A2 - Furau, Cristian
A3 - Furau, Gheorghe
A4 - Dimitriu, Mihai
A5 - Socea, Bogdan
A6 - Codreanu, Ada Maria
A7 - Botezatu, Dragos
A8 - Dumnici, Alexandru
A9 - Totolici, Bogdan
A10 - Barbu, Ion
A11 - Gheorghiu, Nicolae
A12 - Gheorghiu, Diana Claudia
A13 - Miutescu, Eftimie
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 9
SP - 3250
EP - 3253
UR - https://doi.org/10.37358/RC.19.9.7528
KW - types of vessels
KW - GIST
KW - anti-vascular therapy
KW - tyrosine kinase receptor inhibitor
ER -

BibTex
@article{RevCh2019P3250,
author = {Korodi Andrei Dan and Furau Cristian and Furau Gheorghe and Dimitriu Mihai and Socea Bogdan and Codreanu Ada Maria and Botezatu Dragos and Dumnici Alexandru and Totolici Bogdan and Barbu Ion and Gheorghiu Nicolae and Gheorghiu Diana Claudia and Miutescu Eftimie},
title = {Tipurile de vase asociate tumorilor GIST influenteaza eficienta terapiei antivasculare cu inhibitori de receptor tirozin-kinazic},
journal = {Revista de Chimie},
volume = {70},
number = {9},
pages = {3250-3253},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.9.7528},
url = {https://revistadechimie.ro/Articles.asp?ID=7528}
}

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