The Association of Body Mass Index and Ki67 Values in Patients with Endometrial Carcinoma

Furau, Alexandru; Craina, Marius Lucian; Furau, Cristian; Luca, Tudor Constantin; Andor, Bogdan Corneliu; Radu, Daniela; Moleriu, Lavinia Cristina; Bonte, Diana Camelia; Toader, Daniela Oana; Furau, Gheorghe

Alexandru Furau, Marius Lucian Craina, Cristian Furau, Tudor Constantin Luca, Bogdan Corneliu Andor, Daniela Radu, Lavinia Cristina Moleriu, Diana Camelia Bonte, Daniela Oana Toader, Gheorghe Furau

The Association of Body Mass Index and Ki67 Values in Patients with Endometrial Carcinoma

Abstract:

Endometrial cancer begins in the layer of cells that form the lining (endometrium) of the uterus. Endometrial cancer is often detected at an early stage because it frequently produces abnormal vaginal bleeding, which prompts women to see their doctors. If endometrial cancer is discovered early, removing the uterus surgically often cures endometrial cancer. The study included all patients who had been evaluated for vaginal bleeding in Obstetrics and Gynecology Department of Clinical Emergency County Hospital, Timisoara between 2016-2018. Of the 195 cases of uterus scraping, 19 cases were labelled as malignant endometrial pathology. For the statistical analysis we calculated some descriptive statistics for the age parameter and the BMI (body mass index) parameter in our disease sample and we compared the BMI values to the BMI values from the control sample As well, we tested to see if there is an association between the Ki-67 values and the HER-2 / neu status in patients with or without endometrial carcinoma. In order to test the significance we applied a Mann -Whitney test, for a = 0.05 set as a confidence level. Unfortunately, in the case of our study group, type 1 endometrial cancers are found in only 5 cases, unlike other countries where most of endometrial cancers are diagnosed early (80% in the first stage) and the 5-year survival rate is about 95%. In any case, the 5-year survival rate is much lower if there is involvement of regional lymph nodes or distant metastasis (68% and 17%, respectively) - as in our case where all cases were classified as Stage III and IV. By running the statistical test we obtained extremely significant differences in the BMI of our patients (p[0.001), the diseased patients tend to have higher BMI values. As well, when we tested the possible association between the Ki-67 values and the HER-2 / neu status in our two groups (patients with or without endometrial carcinoma) we obtained extremely significant differences (p[0.001). The Ki-67 values are increasing proportionally with the carcinoma staging. An endometrial biopsy is the most commonly used test for endometrial cancer and is very accurate in postmenopausal women.

Keywords:
endometrial carcinoma; HER-2 / neu; Ki-67; immunohistochemistry

Issue: 2019, Volume 70, Issue 9

Pages: 3277-3280

Publication date: 2019/10/15

https://doi.org/10.37358/RC.19.9.7534

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
FURAU, A., CRAINA, M.L., FURAU, C., LUCA, T.C., ANDOR, B.C., RADU, D., MOLERIU, L.C., BONTE, D.C., TOADER, D.O., FURAU, G., The Association of Body Mass Index and Ki67 Values in Patients with Endometrial Carcinoma, Rev. Chim., 70(9), 2019, 3277-3280.

Vancouver
Furau A, Craina ML, Furau C, Luca TC, Andor BC, Radu D, Moleriu LC, Bonte DC, Toader DO, Furau G. The Association of Body Mass Index and Ki67 Values in Patients with Endometrial Carcinoma. Rev. Chim.[internet]. 2019 Sep;70(9):3277-3280. Available from: https://doi.org/10.37358/RC.19.9.7534

APA 6th edition
Furau, A., Craina, M.L., Furau, C., Luca, T.C., Andor, B.C., Radu, D.,... Furau, G. (2019). The Association of Body Mass Index and Ki67 Values in Patients with Endometrial Carcinoma. Revista de Chimie, 70(9), 3277-3280. https://doi.org/10.37358/RC.19.9.7534

Harvard
Furau, A., Craina, M.L., Furau, C., Luca, T.C., Andor, B.C., Radu, D., Moleriu, L.C., Bonte, D.C., Toader, D.O., Furau, G. (2019). 'The Association of Body Mass Index and Ki67 Values in Patients with Endometrial Carcinoma', Revista de Chimie, 70(9), pp. 3277-3280. https://doi.org/10.37358/RC.19.9.7534

IEEE
A. Furau, M.L. Craina, C. Furau, T.C. Luca, B.C. Andor, D. Radu, L.C. Moleriu, D.C. Bonte, D.O. Toader, G. Furau, "The Association of Body Mass Index and Ki67 Values in Patients with Endometrial Carcinoma". Revista de Chimie, vol. 70, no. 9, pp. 3277-3280, 2019. [online]. https://doi.org/10.37358/RC.19.9.7534

Text
Alexandru Furau, Marius Lucian Craina, Cristian Furau, Tudor Constantin Luca, Bogdan Corneliu Andor, Daniela Radu, Lavinia Cristina Moleriu, Diana Camelia Bonte, Daniela Oana Toader, Gheorghe Furau,
The Association of Body Mass Index and Ki67 Values in Patients with Endometrial Carcinoma,
Revista de Chimie,
Volume 70, Issue 9,
2019,
Pages 3277-3280,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.9.7534.
(https://revistadechimie.ro/Articles.asp?ID=7534)
Keywords: endometrial carcinoma; HER-2 / neu; Ki-67; immunohistochemistry

RIS
TY - JOUR
T1 - The Association of Body Mass Index and Ki67 Values in Patients with Endometrial Carcinoma
A1 - Furau, Alexandru
A2 - Craina, Marius Lucian
A3 - Furau, Cristian
A4 - Luca, Tudor Constantin
A5 - Andor, Bogdan Corneliu
A6 - Radu, Daniela
A7 - Moleriu, Lavinia Cristina
A8 - Bonte, Diana Camelia
A9 - Toader, Daniela Oana
A10 - Furau, Gheorghe
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 9
SP - 3277
EP - 3280
UR - https://doi.org/10.37358/RC.19.9.7534
KW - endometrial carcinoma
KW - HER-2 / neu
KW - Ki-67
KW - immunohistochemistry
ER -

BibTex
@article{RevCh2019P3277,
author = {Furau Alexandru and Craina Marius Lucian and Furau Cristian and Luca Tudor Constantin and Andor Bogdan Corneliu and Radu Daniela and Moleriu Lavinia Cristina and Bonte Diana Camelia and Toader Daniela Oana and Furau Gheorghe},
title = {The Association of Body Mass Index and Ki67 Values in Patients with Endometrial Carcinoma},
journal = {Revista de Chimie},
volume = {70},
number = {9},
pages = {3277-3280},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.9.7534},
url = {https://revistadechimie.ro/Articles.asp?ID=7534}
}

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