Comparative Effects of Oral and Injectable Bisphosphonates in Primary Human Gingival Fibroblasts

Balean, Octavia Iulia; Floare, Alin Daniel; Focht, Roxanne; Jumanca, Daniela; Coricovac, Dorina; Pinzaru, Iulia; Galuscan, Atena; Chioran, Doina; Cheveresan, Adelina; Podariu, Angela Codruta

Octavia Iulia Balean, Alin Daniel Floare, Roxanne Focht, Daniela Jumanca, Dorina Coricovac, Iulia Pinzaru, Atena Galuscan, Doina Chioran, Adelina Cheveresan, Angela Codruta Podariu

Comparative Effects of Oral and Injectable Bisphosphonates in Primary Human Gingival Fibroblasts

Abstract:

Bisphosphonates are effective antiresorptive agents frequently used in the treatment of different bone disorders, as osteoporosis, Paget’s disease and tumours that cause osteolysis. A major concern related to bisphosphonates therapy is represented by osteonecrosis of jaw, a serious, debilitating, and mostly, a therapy-resistant disease, reported as a frequent side effect of bisphosphonates. The present study was aimed to assess and compare the effect of four commercially available bisphosphonates, very frequently used as oral (Fosamax - F and Actonel - A) and injectable (Ossica - O and Zoledronic acid - Z) therapy on primary human gingival fibroblasts - HGF viability. Alamar blue cell viability assay was performed to assess the effect of test compounds (1.5; 2.5; 5 and 10 mM) on gingival fibroblasts viability after a 24 h interval. In these experimental conditions, injectable bisphosphonates (O and Z) proved to be safe for HGF cells, whereas oral compounds (F and A) were cytotoxic even at low concentrations.

Keywords:
bisphosphonates; primary human gingival fibroblasts; cell viability; cell morphology.

Issue: 2019, Volume 70, Issue 9

Pages: 3325-3329

Publication date: 2019/10/15

https://doi.org/10.37358/RC.19.9.7542

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
BALEAN, O.I., FLOARE, A.D., FOCHT, R., JUMANCA, D., CORICOVAC, D., PINZARU, I., GALUSCAN, A., CHIORAN, D., CHEVERESAN, A., PODARIU, A.C., Comparative Effects of Oral and Injectable Bisphosphonates in Primary Human Gingival Fibroblasts, Rev. Chim., 70(9), 2019, 3325-3329.

Vancouver
Balean OI, Floare AD, Focht R, Jumanca D, Coricovac D, Pinzaru I, Galuscan A, Chioran D, Cheveresan A, Podariu AC. Comparative Effects of Oral and Injectable Bisphosphonates in Primary Human Gingival Fibroblasts. Rev. Chim.[internet]. 2019 Sep;70(9):3325-3329. Available from: https://doi.org/10.37358/RC.19.9.7542

APA 6th edition
Balean, O.I., Floare, A.D., Focht, R., Jumanca, D., Coricovac, D., Pinzaru, I.,... Podariu, A.C. (2019). Comparative Effects of Oral and Injectable Bisphosphonates in Primary Human Gingival Fibroblasts. Revista de Chimie, 70(9), 3325-3329. https://doi.org/10.37358/RC.19.9.7542

Harvard
Balean, O.I., Floare, A.D., Focht, R., Jumanca, D., Coricovac, D., Pinzaru, I., Galuscan, A., Chioran, D., Cheveresan, A., Podariu, A.C. (2019). 'Comparative Effects of Oral and Injectable Bisphosphonates in Primary Human Gingival Fibroblasts', Revista de Chimie, 70(9), pp. 3325-3329. https://doi.org/10.37358/RC.19.9.7542

IEEE
O.I. Balean, A.D. Floare, R. Focht, D. Jumanca, D. Coricovac, I. Pinzaru, A. Galuscan, D. Chioran, A. Cheveresan, A.C. Podariu, "Comparative Effects of Oral and Injectable Bisphosphonates in Primary Human Gingival Fibroblasts". Revista de Chimie, vol. 70, no. 9, pp. 3325-3329, 2019. [online]. https://doi.org/10.37358/RC.19.9.7542

Text
Octavia Iulia Balean, Alin Daniel Floare, Roxanne Focht, Daniela Jumanca, Dorina Coricovac, Iulia Pinzaru, Atena Galuscan, Doina Chioran, Adelina Cheveresan, Angela Codruta Podariu,
Comparative Effects of Oral and Injectable Bisphosphonates in Primary Human Gingival Fibroblasts,
Revista de Chimie,
Volume 70, Issue 9,
2019,
Pages 3325-3329,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.9.7542.
(https://revistadechimie.ro/Articles.asp?ID=7542)
Keywords: bisphosphonates; primary human gingival fibroblasts; cell viability; cell morphology.

RIS
TY - JOUR
T1 - Comparative Effects of Oral and Injectable Bisphosphonates in Primary Human Gingival Fibroblasts
A1 - Balean, Octavia Iulia
A2 - Floare, Alin Daniel
A3 - Focht, Roxanne
A4 - Jumanca, Daniela
A5 - Coricovac, Dorina
A6 - Pinzaru, Iulia
A7 - Galuscan, Atena
A8 - Chioran, Doina
A9 - Cheveresan, Adelina
A10 - Podariu, Angela Codruta
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 9
SP - 3325
EP - 3329
UR - https://doi.org/10.37358/RC.19.9.7542
KW - bisphosphonates
KW - primary human gingival fibroblasts
KW - cell viability
KW - cell morphology.
ER -

BibTex
@article{RevCh2019P3325,
author = {Balean Octavia Iulia and Floare Alin Daniel and Focht Roxanne and Jumanca Daniela and Coricovac Dorina and Pinzaru Iulia and Galuscan Atena and Chioran Doina and Cheveresan Adelina and Podariu Angela Codruta},
title = {Comparative Effects of Oral and Injectable Bisphosphonates in Primary Human Gingival Fibroblasts},
journal = {Revista de Chimie},
volume = {70},
number = {9},
pages = {3325-3329},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.9.7542},
url = {https://revistadechimie.ro/Articles.asp?ID=7542}
}

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