Biochemical Factors Involved in the Unfavorable Evolution of Prostate Cancer

Marinescu, Ileana; Schenker, Ramona Adriana; Stovicek, Puiu Olivian; Marinescu, Dragos; Ciobanu, Constantin Florin; Papacocea, Serban Iancu; Manea, Mihnea Costin; Papacocea, Razvan Ioan; Manea, Mirela; Chirita, Roxana; Ciobanu, Adela Magdalena

Ileana Marinescu, Ramona Adriana Schenker, Puiu Olivian Stovicek, Dragos Marinescu, Constantin Florin Ciobanu, Serban Iancu Papacocea, Mihnea Costin Manea, Razvan Ioan Papacocea, Mirela Manea, Roxana Chirita, Adela Magdalena Ciobanu

Biochemical Factors Involved in the Unfavorable Evolution of Prostate Cancer

Abstract:

Frequent association of depressive disorder with clinical manifestations in prostate cancer patients raises problems with therapeutic response and adherence to treatment. Androgen deprivation therapies exacerbate depression and cause somatic adverse reactions, mainly represented by obesity, anemia, osteoporosis, muscle atrophy, gynecomastia. Depressive disorders correlate with activation of the hypothalamic-pituitary-adrenal axis (HPA), which induces high cortisol levels. The structural similarity between cortisol and testosterone suggests possible associations with their side effects. Decreased testosterone levels amplify the risk of developing or exacerbating depressive disorders. It is important the early identification of sexual identity and body perception disorders, as well as the interdisciplinary assessment of cognitive status and depression. The direct relationship between elevated PSA and testosterone levels and high depression scores suggests the unfavorable evolution of non-metastatic prostate cancer. It is necessary to evaluate depression from the diagnosis of prostate cancer as well as its dynamic monitoring. Therapeutic resistance raises the issue of early oncologic therapeutic switch and the combination of pharmacological and non-pharmacological antidepressant therapies.

Keywords:
prostate cancer; androgen deprivation; depression; cognitive deficiency

Issue: 2019, Volume 70, Issue 9

Pages: 3343-3347

Publication date: 2019/10/15

https://doi.org/10.37358/RC.19.9.7546

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
MARINESCU, I., SCHENKER, R.A., STOVICEK, P.O., MARINESCU, D., CIOBANU, C.F., PAPACOCEA, S.I., MANEA, M.C., PAPACOCEA, R.I., MANEA, M., CHIRITA, R., CIOBANU, A.M., Biochemical Factors Involved in the Unfavorable Evolution of Prostate Cancer, Rev. Chim., 70(9), 2019, 3343-3347.

Vancouver
Marinescu I, Schenker RA, Stovicek PO, Marinescu D, Ciobanu CF, Papacocea SI, Manea MC, Papacocea RI, Manea M, Chirita R, Ciobanu AM. Biochemical Factors Involved in the Unfavorable Evolution of Prostate Cancer. Rev. Chim.[internet]. 2019 Sep;70(9):3343-3347. Available from: https://doi.org/10.37358/RC.19.9.7546

APA 6th edition
Marinescu, I., Schenker, R.A., Stovicek, P.O., Marinescu, D., Ciobanu, C.F., Papacocea, S.I.,... Ciobanu, A.M. (2019). Biochemical Factors Involved in the Unfavorable Evolution of Prostate Cancer. Revista de Chimie, 70(9), 3343-3347. https://doi.org/10.37358/RC.19.9.7546

Harvard
Marinescu, I., Schenker, R.A., Stovicek, P.O., Marinescu, D., Ciobanu, C.F., Papacocea, S.I., Manea, M.C., Papacocea, R.I., Manea, M., Chirita, R., Ciobanu, A.M. (2019). 'Biochemical Factors Involved in the Unfavorable Evolution of Prostate Cancer', Revista de Chimie, 70(9), pp. 3343-3347. https://doi.org/10.37358/RC.19.9.7546

IEEE
I. Marinescu, R.A. Schenker, P.O. Stovicek, D. Marinescu, C.F. Ciobanu, S.I. Papacocea, M.C. Manea, R.I. Papacocea, M. Manea, R. Chirita, A.M. Ciobanu, "Biochemical Factors Involved in the Unfavorable Evolution of Prostate Cancer". Revista de Chimie, vol. 70, no. 9, pp. 3343-3347, 2019. [online]. https://doi.org/10.37358/RC.19.9.7546

Text
Ileana Marinescu, Ramona Adriana Schenker, Puiu Olivian Stovicek, Dragos Marinescu, Constantin Florin Ciobanu, Serban Iancu Papacocea, Mihnea Costin Manea, Razvan Ioan Papacocea, Mirela Manea, Roxana Chirita, Adela Magdalena Ciobanu,
Biochemical Factors Involved in the Unfavorable Evolution of Prostate Cancer,
Revista de Chimie,
Volume 70, Issue 9,
2019,
Pages 3343-3347,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.9.7546.
(https://revistadechimie.ro/Articles.asp?ID=7546)
Keywords: prostate cancer; androgen deprivation; depression; cognitive deficiency

RIS
TY - JOUR
T1 - Biochemical Factors Involved in the Unfavorable Evolution of Prostate Cancer
A1 - Marinescu, Ileana
A2 - Schenker, Ramona Adriana
A3 - Stovicek, Puiu Olivian
A4 - Marinescu, Dragos
A5 - Ciobanu, Constantin Florin
A6 - Papacocea, Serban Iancu
A7 - Manea, Mihnea Costin
A8 - Papacocea, Razvan Ioan
A9 - Manea, Mirela
A10 - Chirita, Roxana
A11 - Ciobanu, Adela Magdalena
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 9
SP - 3343
EP - 3347
UR - https://doi.org/10.37358/RC.19.9.7546
KW - prostate cancer
KW - androgen deprivation
KW - depression
KW - cognitive deficiency
ER -

BibTex
@article{RevCh2019P3343,
author = {Marinescu Ileana and Schenker Ramona Adriana and Stovicek Puiu Olivian and Marinescu Dragos and Ciobanu Constantin Florin and Papacocea Serban Iancu and Manea Mihnea Costin and Papacocea Razvan Ioan and Manea Mirela and Chirita Roxana and Ciobanu Adela Magdalena},
title = {Biochemical Factors Involved in the Unfavorable Evolution of Prostate Cancer},
journal = {Revista de Chimie},
volume = {70},
number = {9},
pages = {3343-3347},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.9.7546},
url = {https://revistadechimie.ro/Articles.asp?ID=7546}
}

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