Synthesis of Different Analogs of Ab(9-16) Peptide Mass spectrometric evidence for heavy metal binding

Jureschi, Monica; Petre, Brindusa Alina; Ion, Laura; Ciobanu, Catalina Ionica; Sandu, Ion; Drochioiu, Gabi

Monica Jureschi, Brindusa Alina Petre, Laura Ion, Catalina Ionica Ciobanu, Ion Sandu, Gabi Drochioiu

Synthesis of Different Analogs of Ab(9-16) Peptide Mass spectrometric evidence for heavy metal binding

Abstract:

Amyloid-b (Ab) peptides are proteins associated with Alzheimer’s disease (AD), because the extracellular Ab deposits are the main cause of this disorder. The aggregation of Ab has been shown to depend on the interactions with metal ions, such as copper, zinc, aluminum or iron. The N-terminal sequence of Ab(1-42) or Ab(1-40) peptides, namely Ab(1-16) peptide fragment, is considered the metal binding site involved in AD neurodegeneration and amyloidogenesis. Therefore, we have investigated different peptide sequences to understand the role played by some amino acid residues in metal binding. In this paper, we report the chemical synthesis of Ab(9-16) peptide and its analogs by Fmoc/tBu strategy and the mass spectrometric evidence for metal ion binding to newly synthesized peptides. MALDI-ToF mass spectrometry proved to be a reliable tool to detect and identify the metal ion complexes of all peptides investigated with copper, iron and zinc ions.

Keywords:
Chemical synthesis; amyloid peptides; heavy metal binding; copper; iron; zinc; mass spectrometry; Alzheimer’s disease

Issue: 2019, Volume 70, Issue 9

Pages: 3348-3353

Publication date: 2019/10/15

https://doi.org/10.37358/RC.19.9.7547

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
JURESCHI, M., PETRE, B.A., ION, L., CIOBANU, C.I., SANDU, I., DROCHIOIU, G., Synthesis of Different Analogs of Ab(9-16) Peptide Mass spectrometric evidence for heavy metal binding, Rev. Chim., 70(9), 2019, 3348-3353.

Vancouver
Jureschi M, Petre BA, Ion L, Ciobanu CI, Sandu I, Drochioiu G. Synthesis of Different Analogs of Ab(9-16) Peptide Mass spectrometric evidence for heavy metal binding. Rev. Chim.[internet]. 2019 Sep;70(9):3348-3353. Available from: https://doi.org/10.37358/RC.19.9.7547

APA 6th edition
Jureschi, M., Petre, B.A., Ion, L., Ciobanu, C.I., Sandu, I. & Drochioiu, G. (2019). Synthesis of Different Analogs of Ab(9-16) Peptide Mass spectrometric evidence for heavy metal binding. Revista de Chimie, 70(9), 3348-3353. https://doi.org/10.37358/RC.19.9.7547

Harvard
Jureschi, M., Petre, B.A., Ion, L., Ciobanu, C.I., Sandu, I., Drochioiu, G. (2019). 'Synthesis of Different Analogs of Ab(9-16) Peptide Mass spectrometric evidence for heavy metal binding', Revista de Chimie, 70(9), pp. 3348-3353. https://doi.org/10.37358/RC.19.9.7547

IEEE
M. Jureschi, B.A. Petre, L. Ion, C.I. Ciobanu, I. Sandu, G. Drochioiu, "Synthesis of Different Analogs of Ab(9-16) Peptide Mass spectrometric evidence for heavy metal binding". Revista de Chimie, vol. 70, no. 9, pp. 3348-3353, 2019. [online]. https://doi.org/10.37358/RC.19.9.7547

Text
Monica Jureschi, Brindusa Alina Petre, Laura Ion, Catalina Ionica Ciobanu, Ion Sandu, Gabi Drochioiu,
Synthesis of Different Analogs of Ab(9-16) Peptide Mass spectrometric evidence for heavy metal binding,
Revista de Chimie,
Volume 70, Issue 9,
2019,
Pages 3348-3353,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.9.7547.
(https://revistadechimie.ro/Articles.asp?ID=7547)
Keywords: Chemical synthesis; amyloid peptides; heavy metal binding; copper; iron; zinc; mass spectrometry; Alzheimer’s disease

RIS
TY - JOUR
T1 - Synthesis of Different Analogs of Ab(9-16) Peptide Mass spectrometric evidence for heavy metal binding
A1 - Jureschi, Monica
A2 - Petre, Brindusa Alina
A3 - Ion, Laura
A4 - Ciobanu, Catalina Ionica
A5 - Sandu, Ion
A6 - Drochioiu, Gabi
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 9
SP - 3348
EP - 3353
UR - https://doi.org/10.37358/RC.19.9.7547
KW - Chemical synthesis
KW - amyloid peptides
KW - heavy metal binding
KW - copper
KW - iron
KW - zinc
KW - mass spectrometry
KW - Alzheimer’s disease
ER -

BibTex
@article{RevCh2019P3348,
author = {Jureschi Monica and Petre Brindusa Alina and Ion Laura and Ciobanu Catalina Ionica and Sandu Ion and Drochioiu Gabi},
title = {Synthesis of Different Analogs of Ab(9-16) Peptide Mass spectrometric evidence for heavy metal binding},
journal = {Revista de Chimie},
volume = {70},
number = {9},
pages = {3348-3353},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.9.7547},
url = {https://revistadechimie.ro/Articles.asp?ID=7547}
}

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