Preliminary Results of Betulinic Acid-Loaded Magnetoliposomes - a Potential Approach to Increase Therapeutic Efficacy in Melanoma

Farcas, Claudia Geanina; Moaca, Elena Alina; Dragoi, Razvan; Vaduva, Delia Berceanu; Marcovici, Iasmina; Mihali, Ciprian Valentin; Loghin, Felicia

Claudia Geanina Farcas, Elena Alina Moaca, Razvan Dragoi, Delia Berceanu Vaduva, Iasmina Marcovici, Ciprian Valentin Mihali, Felicia Loghin

Preliminary Results of Betulinic Acid-Loaded Magnetoliposomes - a Potential Approach to Increase Therapeutic Efficacy in Melanoma

Abstract:

Magnetoliposomes were placed into the biomedical spotlight due to their unique structure, preserving also magnetic features valuable for biomedical applications. The present study provides a preliminary evidence of the cytotoxicity induced by betulinic acid-loaded magnetoliposomes (BA-Fe3O4@Lip) on two melanoma cell lines - A375 and B164A5 cells and one healthy cell line - mice epidermis JB6 Cl 41-5a cells, augmented by references to potential biomedical applications. BA-Fe3O4@Lip showed significant cytotoxicity on the melanoma cell lines, compared with the blank liposomal structures. In addition, the healthy cell line displayed good viability rate after exposure to BA-Fe3O4@Lip.

Keywords:
betulinic acid; thermosensitive magnetoliposomes; cytotoxicity; melanoma cells

Issue: 2019, Volume 70, Issue 9

Pages: 3372-3377

Publication date: 2019/10/15

https://doi.org/10.37358/RC.19.9.7552

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
FARCAS, C.G., MOACA, E.A., DRAGOI, R., VADUVA, D.B., MARCOVICI, I., MIHALI, C.V., LOGHIN, F., Preliminary Results of Betulinic Acid-Loaded Magnetoliposomes - a Potential Approach to Increase Therapeutic Efficacy in Melanoma, Rev. Chim., 70(9), 2019, 3372-3377.

Vancouver
Farcas CG, Moaca EA, Dragoi R, Vaduva DB, Marcovici I, Mihali CV, Loghin F. Preliminary Results of Betulinic Acid-Loaded Magnetoliposomes - a Potential Approach to Increase Therapeutic Efficacy in Melanoma. Rev. Chim.[internet]. 2019 Sep;70(9):3372-3377. Available from: https://doi.org/10.37358/RC.19.9.7552

APA 6th edition
Farcas, C.G., Moaca, E.A., Dragoi, R., Vaduva, D.B., Marcovici, I., Mihali, C.V. & Loghin, F. (2019). Preliminary Results of Betulinic Acid-Loaded Magnetoliposomes - a Potential Approach to Increase Therapeutic Efficacy in Melanoma. Revista de Chimie, 70(9), 3372-3377. https://doi.org/10.37358/RC.19.9.7552

Harvard
Farcas, C.G., Moaca, E.A., Dragoi, R., Vaduva, D.B., Marcovici, I., Mihali, C.V., Loghin, F. (2019). 'Preliminary Results of Betulinic Acid-Loaded Magnetoliposomes - a Potential Approach to Increase Therapeutic Efficacy in Melanoma', Revista de Chimie, 70(9), pp. 3372-3377. https://doi.org/10.37358/RC.19.9.7552

IEEE
C.G. Farcas, E.A. Moaca, R. Dragoi, D.B. Vaduva, I. Marcovici, C.V. Mihali, F. Loghin, "Preliminary Results of Betulinic Acid-Loaded Magnetoliposomes - a Potential Approach to Increase Therapeutic Efficacy in Melanoma". Revista de Chimie, vol. 70, no. 9, pp. 3372-3377, 2019. [online]. https://doi.org/10.37358/RC.19.9.7552

Text
Claudia Geanina Farcas, Elena Alina Moaca, Razvan Dragoi, Delia Berceanu Vaduva, Iasmina Marcovici, Ciprian Valentin Mihali, Felicia Loghin,
Preliminary Results of Betulinic Acid-Loaded Magnetoliposomes - a Potential Approach to Increase Therapeutic Efficacy in Melanoma,
Revista de Chimie,
Volume 70, Issue 9,
2019,
Pages 3372-3377,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.9.7552.
(https://revistadechimie.ro/Articles.asp?ID=7552)
Keywords: betulinic acid; thermosensitive magnetoliposomes; cytotoxicity; melanoma cells

RIS
TY - JOUR
T1 - Preliminary Results of Betulinic Acid-Loaded Magnetoliposomes - a Potential Approach to Increase Therapeutic Efficacy in Melanoma
A1 - Farcas, Claudia Geanina
A2 - Moaca, Elena Alina
A3 - Dragoi, Razvan
A4 - Vaduva, Delia Berceanu
A5 - Marcovici, Iasmina
A6 - Mihali, Ciprian Valentin
A7 - Loghin, Felicia
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 9
SP - 3372
EP - 3377
UR - https://doi.org/10.37358/RC.19.9.7552
KW - betulinic acid
KW - thermosensitive magnetoliposomes
KW - cytotoxicity
KW - melanoma cells
ER -

BibTex
@article{RevCh2019P3372,
author = {Farcas Claudia Geanina and Moaca Elena Alina and Dragoi Razvan and Vaduva Delia Berceanu and Marcovici Iasmina and Mihali Ciprian Valentin and Loghin Felicia},
title = {Preliminary Results of Betulinic Acid-Loaded Magnetoliposomes - a Potential Approach to Increase Therapeutic Efficacy in Melanoma},
journal = {Revista de Chimie},
volume = {70},
number = {9},
pages = {3372-3377},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.9.7552},
url = {https://revistadechimie.ro/Articles.asp?ID=7552}
}

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