The Non-linear Association Between Serum Level of Anti-Müllerian Hormone and in vitro Fertilisation Outcome

Albu, Dragos Nicolae; Albu, Alice Ioana; Olaru, Gabriel Octavian; Sima, Romina Marina; Neacsu, Adrian; Chicea, Radu; Nicolae, Camelia; Matei, Alexandra; Ples, Liana

Dragos Nicolae Albu, Alice Ioana Albu, Gabriel Octavian Olaru, Romina Marina Sima, Adrian Neacsu, Radu Chicea, Camelia Nicolae, Alexandra Matei, Liana Ples

The Non-linear Association Between Serum Level of Anti-Müllerian Hormone and in vitro Fertilisation Outcome

Abstract:

Aim of the study was to analyse the relationship between Anti-Müllerian Hormone (AMH) serum level and in vitro fertilisation (IVF) with and without intra-cytoplasmic sperm injection (ICSI) outcome. We performed a retrospective study which included 1073 patients (mean age 34.68±4.28 years, mean body mass index 22.7±15.65 kg/m2) who performed IVF or IVF/ICSI between January 2013 and December 2016.We found that AMH serum level was age-independent positively related with oocytes (beta=0.329, p[0.0001) and zygotes number (beta=0.248, p[0.0001) and negatively correlated with fertilization rate (beta=-0.108, p=0.001). In multivariate regression, after adjustment for confounders, only oocytes number, but not AMH serum level, was associated with zygotes number (beta=0.814, p[0.0001) and fertilisation rate (beta=- 0.133, p=0.001). Patients with AMH in the range 1.1-5 ng/mL had significantly higher biochemical (65.3% versus 56.6%, p=0.009) and clinical pregnancy rates (57.7% versus 49.2%, p=0.014) in comparison with patients with AMH below 1.1 ng/mL and higher clinical pregnancy rates in comparison with patients with AMH above 7 ng/mL (57.7% versus 44%, p=0.011). Logistic regression analysis showed that AMH was positively associated with biochemical (OR 1.19, p=0.003) and clinical pregnancy (OR 1.16, p=0.009) independently of age and number of good embryos transferred in patients with AMH below 5 ng/mL. In turn, when only patients with normal ovarian reserve were analysed (AMH above 1.1 ng/mL), we found an age-independent negative association between AMH and clinical pregnancy (OR 0.93, p=0.014). AMH serum level is associated with both quantitative response (oocytes number) and qualitative parameters (pregnancy rate) during IVF/ICSI. We also found a bimodal relationship between AMH and pregnancy rates, which were positively associated in patients with AMH below 5 ng/mL, although higher AMH values seem to have a negative impact on pregnancy chances.

Keywords:
AMH; IVF outcome; oocytes competence; fertilisation rate; pregnancy

Issue: 2019, Volume 70, Issue 9

Pages: 3392-3398

Publication date: 2019/10/15

https://doi.org/10.37358/RC.19.9.7556

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
ALBU, D.N., ALBU, A.I., OLARU, G.O., SIMA, R.M., NEACSU, A., CHICEA, R., NICOLAE, C., MATEI, A., PLES, L., The Non-linear Association Between Serum Level of Anti-Müllerian Hormone and in vitro Fertilisation Outcome, Rev. Chim., 70(9), 2019, 3392-3398.

Vancouver
Albu DN, Albu AI, Olaru GO, Sima RM, Neacsu A, Chicea R, Nicolae C, Matei A, Ples L. The Non-linear Association Between Serum Level of Anti-Müllerian Hormone and in vitro Fertilisation Outcome. Rev. Chim.[internet]. 2019 Sep;70(9):3392-3398. Available from: https://doi.org/10.37358/RC.19.9.7556

APA 6th edition
Albu, D.N., Albu, A.I., Olaru, G.O., Sima, R.M., Neacsu, A., Chicea, R.,... Ples, L. (2019). The Non-linear Association Between Serum Level of Anti-Müllerian Hormone and in vitro Fertilisation Outcome. Revista de Chimie, 70(9), 3392-3398. https://doi.org/10.37358/RC.19.9.7556

Harvard
Albu, D.N., Albu, A.I., Olaru, G.O., Sima, R.M., Neacsu, A., Chicea, R., Nicolae, C., Matei, A., Ples, L. (2019). 'The Non-linear Association Between Serum Level of Anti-Müllerian Hormone and in vitro Fertilisation Outcome', Revista de Chimie, 70(9), pp. 3392-3398. https://doi.org/10.37358/RC.19.9.7556

IEEE
D.N. Albu, A.I. Albu, G.O. Olaru, R.M. Sima, A. Neacsu, R. Chicea, C. Nicolae, A. Matei, L. Ples, "The Non-linear Association Between Serum Level of Anti-Müllerian Hormone and in vitro Fertilisation Outcome". Revista de Chimie, vol. 70, no. 9, pp. 3392-3398, 2019. [online]. https://doi.org/10.37358/RC.19.9.7556

Text
Dragos Nicolae Albu, Alice Ioana Albu, Gabriel Octavian Olaru, Romina Marina Sima, Adrian Neacsu, Radu Chicea, Camelia Nicolae, Alexandra Matei, Liana Ples,
The Non-linear Association Between Serum Level of Anti-Müllerian Hormone and in vitro Fertilisation Outcome,
Revista de Chimie,
Volume 70, Issue 9,
2019,
Pages 3392-3398,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.9.7556.
(https://revistadechimie.ro/Articles.asp?ID=7556)
Keywords: AMH; IVF outcome; oocytes competence; fertilisation rate; pregnancy

RIS
TY - JOUR
T1 - The Non-linear Association Between Serum Level of Anti-Müllerian Hormone and in vitro Fertilisation Outcome
A1 - Albu, Dragos Nicolae
A2 - Albu, Alice Ioana
A3 - Olaru, Gabriel Octavian
A4 - Sima, Romina Marina
A5 - Neacsu, Adrian
A6 - Chicea, Radu
A7 - Nicolae, Camelia
A8 - Matei, Alexandra
A9 - Ples, Liana
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 9
SP - 3392
EP - 3398
UR - https://doi.org/10.37358/RC.19.9.7556
KW - AMH
KW - IVF outcome
KW - oocytes competence
KW - fertilisation rate
KW - pregnancy
ER -

BibTex
@article{RevCh2019P3392,
author = {Albu Dragos Nicolae and Albu Alice Ioana and Olaru Gabriel Octavian and Sima Romina Marina and Neacsu Adrian and Chicea Radu and Nicolae Camelia and Matei Alexandra and Ples Liana},
title = {The Non-linear Association Between Serum Level of Anti-Müllerian Hormone and in vitro Fertilisation Outcome},
journal = {Revista de Chimie},
volume = {70},
number = {9},
pages = {3392-3398},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.9.7556},
url = {https://revistadechimie.ro/Articles.asp?ID=7556}
}

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