The Vogt-Koyanagi-Harada and SAPHO Syndrome: An Unusual Association

Palade, Dragos; Damian, Laura Otilia; Radeanu, Doinel; Stefanut, Anne Claudia; Cobzac, Gheorghe; Stefanescu, Cristian Dragos; Maniu, Alma

Dragos Palade, Laura Otilia Damian, Doinel Radeanu, Anne Claudia Stefanut, Gheorghe Cobzac, Cristian Dragos Stefanescu, Alma Maniu

The Vogt-Koyanagi-Harada and SAPHO Syndrome: An Unusual Association

Abstract:

Vogt-Koyanagi-Harada syndrome(VKH) is a multisystemic disorder characterized by granulomatous panuveitis and cutaneous, otorhynolaryngologic and neurologic involvement, due to an autoimmune reaction against melanocytic antigens. Autoinflammatory associations of VKH, including inflammatory bowel disease and psoriasis, were rarely described. SAPHO syndrome (an acronym for synovitis, acne, hyperostosis, pustulosis and osteitis) is a rare autoinflammatorymusculo-scheletal disease. This paper reports on a male patient presenting for long-lasting bone and joint pain, dysphagia,having a ten-year history of bilateral optic neuritiswhich required high-dose corticosteroids. Fundoscopy revealed diffuse chorioretinalnonpigmented atrophic lesions. Vitiligo, acne scars, clavicular deformity, recurrent chest pain and sacroiliitis pointed to a long-standing SAPHO syndrome and late-phase VKH. Blood tests found inflammation and anti-hepatitis C antibodies with repeatedly undetectable viremia. Bone scintigraphy with the characteristic bull’s head upper chest uptake and the radiographs confirmed SAPHO syndrome. The patient was treated with sulphasalazine and cyclosporin A, with alleviation of the articular and bony disease. In conclusion, SAPHO syndrome may add to the list of the diseases associated with VKH. Although VKH and SAPHO syndrome may have appeared coincidentally, a common pathogenesis involving an infectious trigger and IL-17 could be considered.

Keywords:
Vogt-Koyanagi-Harada disease; SAPHO syndrome; autoinflammatory; P. acnes; interleukin-17

Issue: 2019, Volume 70, Issue 9

Pages: 3441-3443

Publication date: 2019/10/15

https://doi.org/10.37358/RC.19.9.7566

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
PALADE, D., DAMIAN, L.O., RADEANU, D., STEFANUT, A.C., COBZAC, G., STEFANESCU, C.D., MANIU, A., The Vogt-Koyanagi-Harada and SAPHO Syndrome: An Unusual Association, Rev. Chim., 70(9), 2019, 3441-3443.

Vancouver
Palade D, Damian LO, Radeanu D, Stefanut AC, Cobzac G, Stefanescu CD, Maniu A. The Vogt-Koyanagi-Harada and SAPHO Syndrome: An Unusual Association. Rev. Chim.[internet]. 2019 Sep;70(9):3441-3443. Available from: https://doi.org/10.37358/RC.19.9.7566

APA 6th edition
Palade, D., Damian, L.O., Radeanu, D., Stefanut, A.C., Cobzac, G., Stefanescu, C.D. & Maniu, A. (2019). The Vogt-Koyanagi-Harada and SAPHO Syndrome: An Unusual Association. Revista de Chimie, 70(9), 3441-3443. https://doi.org/10.37358/RC.19.9.7566

Harvard
Palade, D., Damian, L.O., Radeanu, D., Stefanut, A.C., Cobzac, G., Stefanescu, C.D., Maniu, A. (2019). 'The Vogt-Koyanagi-Harada and SAPHO Syndrome: An Unusual Association', Revista de Chimie, 70(9), pp. 3441-3443. https://doi.org/10.37358/RC.19.9.7566

IEEE
D. Palade, L.O. Damian, D. Radeanu, A.C. Stefanut, G. Cobzac, C.D. Stefanescu, A. Maniu, "The Vogt-Koyanagi-Harada and SAPHO Syndrome: An Unusual Association". Revista de Chimie, vol. 70, no. 9, pp. 3441-3443, 2019. [online]. https://doi.org/10.37358/RC.19.9.7566

Text
Dragos Palade, Laura Otilia Damian, Doinel Radeanu, Anne Claudia Stefanut, Gheorghe Cobzac, Cristian Dragos Stefanescu, Alma Maniu,
The Vogt-Koyanagi-Harada and SAPHO Syndrome: An Unusual Association,
Revista de Chimie,
Volume 70, Issue 9,
2019,
Pages 3441-3443,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.9.7566.
(https://revistadechimie.ro/Articles.asp?ID=7566)
Keywords: Vogt-Koyanagi-Harada disease; SAPHO syndrome; autoinflammatory; P. acnes; interleukin-17

RIS
TY - JOUR
T1 - The Vogt-Koyanagi-Harada and SAPHO Syndrome: An Unusual Association
A1 - Palade, Dragos
A2 - Damian, Laura Otilia
A3 - Radeanu, Doinel
A4 - Stefanut, Anne Claudia
A5 - Cobzac, Gheorghe
A6 - Stefanescu, Cristian Dragos
A7 - Maniu, Alma
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 9
SP - 3441
EP - 3443
UR - https://doi.org/10.37358/RC.19.9.7566
KW - Vogt-Koyanagi-Harada disease
KW - SAPHO syndrome
KW - autoinflammatory
KW - P. acnes
KW - interleukin-17
ER -

BibTex
@article{RevCh2019P3441,
author = {Palade Dragos and Damian Laura Otilia and Radeanu Doinel and Stefanut Anne Claudia and Cobzac Gheorghe and Stefanescu Cristian Dragos and Maniu Alma},
title = {The Vogt-Koyanagi-Harada and SAPHO Syndrome: An Unusual Association},
journal = {Revista de Chimie},
volume = {70},
number = {9},
pages = {3441-3443},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.9.7566},
url = {https://revistadechimie.ro/Articles.asp?ID=7566}
}

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