Prediction Models of Albumin Renal Excretion in Type 2 Diabetes Mellitus Patients

Popa, Amorin Remus; Pusta, Claudia Teodora Judea; Vesa, Cosmin Mihai; Bungau, Simona; Buhas, Camelia Liana; Sava, Cristian; Dimulescu (Nica), Ioana Alina; Zaha, Dana Carmen; Bustea, Cristiana

Amorin Remus Popa, Claudia Teodora Judea Pusta, Cosmin Mihai Vesa, Simona Bungau, Camelia Liana Buhas, Cristian Sava, Ioana Alina Dimulescu (Nica), Dana Carmen Zaha, Cristiana Bustea

Prediction Models of Albumin Renal Excretion in Type 2 Diabetes Mellitus Patients

Abstract:

Microalbuminuria is a cardiovascular risk factor in type 2 diabetes mellitus patients. It is very important to know which the predictor factors for albuminuria are, because these elements may be influenced by pharmacological measures. In our study we propose three models for the prediction of albumin glomerular excretion in a group of 446 type 2 diabetes mellitus patients: the clinical-biochemical model, the pharmacological model, and the integrative model that reunites the two models. In the clinical-biochemical model, albumin excretion was statistically significant influenced by HbA1c (positive correlation) and blood pressure (positive correlation). In the pharmacological model, albumin excretion was influenced by angiotensin converting enzyme inhibitors or angiotensin II receptor blockers treatment (negative correlation). In the integrative model, the factors were HbA1c (positive correlation), diastolic blood pressure (positive correlation), angiotensin converting enzyme inhibitors or angiotensin II receptor blockers treatment (negative correlation) and statins treatment (negative correlation). The prevalence of microalbuminuria was 16.14 %. Patients with microalbuminuria had statistically significant higher values of HbA1c, systolic blood pressure, diastolic blood pressure, triglycerides and lower values of HDL-cholesterol. A low glucose control was the most important risk factor for an increased albumin glomerular elimination. The importance of our study consists in the fact that all the elements that predict albuminuria can be influenced: HbA1c, blood pressure, therapy with angiotensin converting enzyme inhibitors or angiotensin II receptor blockers and statins.

Keywords:
Kalbuminuria; type 2 diabetes mellitus; endothelial dysfunction; ACEI; ARB; statins

Issue: 2019, Volume 70, Issue 11

Pages: 3802-3807

Publication date: 2019/12/15

https://doi.org/10.37358/RC.70.19.11.7650

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
POPA, A.R., PUSTA, C.T.J., VESA, C.M., BUNGAU, S., BUHAS, C.L., SAVA, C., DIMULESCU (NICA), I.A., ZAHA, D.C., BUSTEA, C., Prediction Models of Albumin Renal Excretion in Type 2 Diabetes Mellitus Patients, Rev. Chim., 70(11), 2019, 3802-3807.

Vancouver
Popa AR, Pusta CTJ, Vesa CM, Bungau S, Buhas CL, Sava C, Dimulescu (Nica) IA, Zaha DC, Bustea C. Prediction Models of Albumin Renal Excretion in Type 2 Diabetes Mellitus Patients. Rev. Chim.[internet]. 2019 Nov;70(11):3802-3807. Available from: https://doi.org/10.37358/RC.70.19.11.7650

APA 6th edition
Popa, A.R., Pusta, C.T.J., Vesa, C.M., Bungau, S., Buhas, C.L., Sava, C.,... Bustea, C. (2019). Prediction Models of Albumin Renal Excretion in Type 2 Diabetes Mellitus Patients. Revista de Chimie, 70(11), 3802-3807. https://doi.org/10.37358/RC.70.19.11.7650

Harvard
Popa, A.R., Pusta, C.T.J., Vesa, C.M., Bungau, S., Buhas, C.L., Sava, C., Dimulescu (Nica), I.A., Zaha, D.C., Bustea, C. (2019). 'Prediction Models of Albumin Renal Excretion in Type 2 Diabetes Mellitus Patients', Revista de Chimie, 70(11), pp. 3802-3807. https://doi.org/10.37358/RC.70.19.11.7650

IEEE
A.R. Popa, C.T.J. Pusta, C.M. Vesa, S. Bungau, C.L. Buhas, C. Sava, I.A. Dimulescu(Nica), D.C. Zaha, C. Bustea, "Prediction Models of Albumin Renal Excretion in Type 2 Diabetes Mellitus Patients". Revista de Chimie, vol. 70, no. 11, pp. 3802-3807, 2019. [online]. https://doi.org/10.37358/RC.70.19.11.7650

Text
Amorin Remus Popa, Claudia Teodora Judea Pusta, Cosmin Mihai Vesa, Simona Bungau, Camelia Liana Buhas, Cristian Sava, Ioana Alina Dimulescu(Nica), Dana Carmen Zaha, Cristiana Bustea,
Prediction Models of Albumin Renal Excretion in Type 2 Diabetes Mellitus Patients,
Revista de Chimie,
Volume 70, Issue 11,
2019,
Pages 3802-3807,
ISSN 2668-8212,
https://doi.org/10.37358/RC.70.19.11.7650.
(https://revistadechimie.ro/Articles.asp?ID=7650)
Keywords: Kalbuminuria; type 2 diabetes mellitus; endothelial dysfunction; ACEI; ARB; statins

RIS
TY - JOUR
T1 - Prediction Models of Albumin Renal Excretion in Type 2 Diabetes Mellitus Patients
A1 - Popa, Amorin Remus
A2 - Pusta, Claudia Teodora Judea
A3 - Vesa, Cosmin Mihai
A4 - Bungau, Simona
A5 - Buhas, Camelia Liana
A6 - Sava, Cristian
A7 - Dimulescu (Nica), Ioana Alina
A8 - Zaha, Dana Carmen
A9 - Bustea, Cristiana
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 11
SP - 3802
EP - 3807
UR - https://doi.org/10.37358/RC.70.19.11.7650
KW - Kalbuminuria
KW - type 2 diabetes mellitus
KW - endothelial dysfunction
KW - ACEI
KW - ARB
KW - statins
ER -

BibTex
@article{RevCh2019P3802,
author = {Popa Amorin Remus and Pusta Claudia Teodora Judea and Vesa Cosmin Mihai and Bungau Simona and Buhas Camelia Liana and Sava Cristian and Dimulescu (Nica) Ioana Alina and Zaha Dana Carmen and Bustea Cristiana},
title = {Prediction Models of Albumin Renal Excretion in Type 2 Diabetes Mellitus Patients},
journal = {Revista de Chimie},
volume = {70},
number = {11},
pages = {3802-3807},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.70.19.11.7650},
url = {https://revistadechimie.ro/Articles.asp?ID=7650}
}

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