Evaluation of Plasmatic Levels of Negative and Positive Acute Hepatic Phase  Proteins in Patients who Underwent Major Surgery

Nicolescu, Laura; Totolici, Bogdan; Bedreag, Ovidiu; Nicolescu, Cristian; Mihu, Alin

Laura Nicolescu, Bogdan Totolici, Ovidiu Bedreag, Cristian Nicolescu, Alin Mihu

Evaluation of Plasmatic Levels of Negative and Positive Acute Hepatic Phase Proteins in Patients who Underwent Major Surgery

Abstract:

The acute hepatic phase response is defined as a reaction that includes hepatic synthesis of proteins, consisting in the increase of some proteins called positive acute phase proteins and the simultaneous decrease of others called negative acute phase proteins. This study describes this hepatic reaction, based on a series of consecutive determinations, at three different time intervals (right before a major surgery event, 24 and 48 hours after the intervention), of the plasmatic levels of transferrin, albumin, fibrinogen and C reactive protein (CRP). Subsequently, the data was analyzed using Jamovi 2019, version 0.9. The inferential statistics consisted in calculating an ANOVA test that compared the values at 24 hours and 48 hours versus the values right before the major surgery. The results were validated by calculating the p value (p[0.05) as well as conducting correlation tests by determining the Pearson coefficient which shows the values of CRP, fibrinogen, transferrin and albumin are independent of each other and do not interact. The multiple ANOVA comparative test reveals the lack of interaction between the values of determined proteins, regardless of the moment of determination.

Keywords:
albumin; transferrin; C reactive protein; fibrinogen; acute phase protein

Issue: 2019, Volume 70, Issue 11

Pages: 3947-3953

Publication date: 2019/12/15

https://doi.org/10.37358/RC.70.19.11.7678

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
NICOLESCU, L., TOTOLICI, B., BEDREAG, O., NICOLESCU, C., MIHU, A., Evaluation of Plasmatic Levels of Negative and Positive Acute Hepatic Phase Proteins in Patients who Underwent Major Surgery, Rev. Chim., 70(11), 2019, 3947-3953.

Vancouver
Nicolescu L, Totolici B, Bedreag O, Nicolescu C, Mihu A. Evaluation of Plasmatic Levels of Negative and Positive Acute Hepatic Phase Proteins in Patients who Underwent Major Surgery. Rev. Chim.[internet]. 2019 Nov;70(11):3947-3953. Available from: https://doi.org/10.37358/RC.70.19.11.7678

APA 6th edition
Nicolescu, L., Totolici, B., Bedreag, O., Nicolescu, C. & Mihu, A. (2019). Evaluation of Plasmatic Levels of Negative and Positive Acute Hepatic Phase Proteins in Patients who Underwent Major Surgery. Revista de Chimie, 70(11), 3947-3953. https://doi.org/10.37358/RC.70.19.11.7678

Harvard
Nicolescu, L., Totolici, B., Bedreag, O., Nicolescu, C., Mihu, A. (2019). 'Evaluation of Plasmatic Levels of Negative and Positive Acute Hepatic Phase Proteins in Patients who Underwent Major Surgery', Revista de Chimie, 70(11), pp. 3947-3953. https://doi.org/10.37358/RC.70.19.11.7678

IEEE
L. Nicolescu, B. Totolici, O. Bedreag, C. Nicolescu, A. Mihu, "Evaluation of Plasmatic Levels of Negative and Positive Acute Hepatic Phase Proteins in Patients who Underwent Major Surgery". Revista de Chimie, vol. 70, no. 11, pp. 3947-3953, 2019. [online]. https://doi.org/10.37358/RC.70.19.11.7678

Text
Laura Nicolescu, Bogdan Totolici, Ovidiu Bedreag, Cristian Nicolescu, Alin Mihu,
Evaluation of Plasmatic Levels of Negative and Positive Acute Hepatic Phase Proteins in Patients who Underwent Major Surgery,
Revista de Chimie,
Volume 70, Issue 11,
2019,
Pages 3947-3953,
ISSN 2668-8212,
https://doi.org/10.37358/RC.70.19.11.7678.
(https://revistadechimie.ro/Articles.asp?ID=7678)
Keywords: albumin; transferrin; C reactive protein; fibrinogen; acute phase protein

RIS
TY - JOUR
T1 - Evaluation of Plasmatic Levels of Negative and Positive Acute Hepatic Phase Proteins in Patients who Underwent Major Surgery
A1 - Nicolescu, Laura
A2 - Totolici, Bogdan
A3 - Bedreag, Ovidiu
A4 - Nicolescu, Cristian
A5 - Mihu, Alin
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 11
SP - 3947
EP - 3953
UR - https://doi.org/10.37358/RC.70.19.11.7678
KW - albumin
KW - transferrin
KW - C reactive protein
KW - fibrinogen
KW - acute phase protein
ER -

BibTex
@article{RevCh2019P3947,
author = {Nicolescu Laura and Totolici Bogdan and Bedreag Ovidiu and Nicolescu Cristian and Mihu Alin},
title = {Evaluation of Plasmatic Levels of Negative and Positive Acute Hepatic Phase Proteins in Patients who Underwent Major Surgery},
journal = {Revista de Chimie},
volume = {70},
number = {11},
pages = {3947-3953},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.70.19.11.7678},
url = {https://revistadechimie.ro/Articles.asp?ID=7678}
}

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