Synthesis, Characterization and Biological Activity of Two New Copper (II) Complexes with N-sulfonamide Ligand

Hangan, Adriana Corina; Vicas, Laura Gratiela; Stan, Roxana Liana; Pall, Emoke; Oprean, Luminita Simona; Ionescu, Corina Maria Lucia; Andrei, Sanda; Berghian, Alexandra Cristina Sevastre; Marian, Eleonora; Sevastre, Bogdan

Adriana Corina Hangan, Laura Gratiela Vicas, Roxana Liana Stan, Emoke Pall, Luminita Simona Oprean, Corina Maria Lucia Ionescu, Sanda Andrei, Alexandra Cristina Sevastre Berghian, Eleonora Marian, Bogdan Sevastre

Synthesis, Characterization and Biological Activity of Two New Copper (II) Complexes with N-sulfonamide Ligand

Abstract:

Despite the fact that a large number of chemotherapeutic anticancer agents have been discovered, cancer still remains a great cause of deaths worldwide. The purpose of our researches is to discover a new antitumor drug. In this aim, two new Cu(II) complexes, [Cu(L)2(py)2(H2O)2](C1) and [Cu(L)2(phen)](C2) with a new ligand, N-(5-trifluoromethyl-[1,3,4]-thiadiazole-2-yl)-benzensulfonamide(HL) were synthesized. The complexes were characterized by elemental analysis, spectral and magnetic determinations. The nuclease activity studies of the complexes confirm their capacity to cleavage the DNA molecule. Both complexes have in vitro antioxidant activity (DPPH, FRAP methods), in vitro (using xanthine /xanthine oxidase system) and in vivo (using S.cerevisiae)SOD mimetic activity.The results of MTT assay on two carcinoma cell lines (HeLa and WM35) indicate that both complexes have antitumor activity, but (C2) has a superior activity compared with (C1) and with Cisplatin. On normal fibroblast (HDFa), (C1) showed toxicity comparable with Cisplatin, but (C2) showed a lower one. Bacterial assays were also performed (by the disk diffusion method) and both complexes have antibacterial activity against S. aureus, E. coli, P. aeroginosa and B. cereus. All the biological studies are in concordance and show that both complexes have biologic activity but (C2)is much more active.

Keywords:
oxidative DNA cleavage; antioxidant capacity; SOD-mimetic activity; cytotoxicity; antibacterial properties

Issue: 2019, Volume 70, Issue 11

Pages: 4060-4067

Publication date: 2019/12/15

https://doi.org/10.37358/RC.70.19.11.7702

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
HANGAN, A.C., VICAS, L.G., STAN, R.L., PALL, E., OPREAN, L.S., IONESCU, C.M.L., ANDREI, S., BERGHIAN, A.C.S., MARIAN, E., SEVASTRE, B., Synthesis, Characterization and Biological Activity of Two New Copper (II) Complexes with N-sulfonamide Ligand, Rev. Chim., 70(11), 2019, 4060-4067.

Vancouver
Hangan AC, Vicas LG, Stan RL, Pall E, Oprean LS, Ionescu CML, Andrei S, Berghian ACS, Marian E, Sevastre B. Synthesis, Characterization and Biological Activity of Two New Copper (II) Complexes with N-sulfonamide Ligand. Rev. Chim.[internet]. 2019 Nov;70(11):4060-4067. Available from: https://doi.org/10.37358/RC.70.19.11.7702

APA 6th edition
Hangan, A.C., Vicas, L.G., Stan, R.L., Pall, E., Oprean, L.S., Ionescu, C.M.L.,... Sevastre, B. (2019). Synthesis, Characterization and Biological Activity of Two New Copper (II) Complexes with N-sulfonamide Ligand. Revista de Chimie, 70(11), 4060-4067. https://doi.org/10.37358/RC.70.19.11.7702

Harvard
Hangan, A.C., Vicas, L.G., Stan, R.L., Pall, E., Oprean, L.S., Ionescu, C.M.L., Andrei, S., Berghian, A.C.S., Marian, E., Sevastre, B. (2019). 'Synthesis, Characterization and Biological Activity of Two New Copper (II) Complexes with N-sulfonamide Ligand', Revista de Chimie, 70(11), pp. 4060-4067. https://doi.org/10.37358/RC.70.19.11.7702

IEEE
A.C. Hangan, L.G. Vicas, R.L. Stan, E. Pall, L.S. Oprean, C.M.L. Ionescu, S. Andrei, A.C.S. Berghian, E. Marian, B. Sevastre, "Synthesis, Characterization and Biological Activity of Two New Copper (II) Complexes with N-sulfonamide Ligand". Revista de Chimie, vol. 70, no. 11, pp. 4060-4067, 2019. [online]. https://doi.org/10.37358/RC.70.19.11.7702

Text
Adriana Corina Hangan, Laura Gratiela Vicas, Roxana Liana Stan, Emoke Pall, Luminita Simona Oprean, Corina Maria Lucia Ionescu, Sanda Andrei, Alexandra Cristina Sevastre Berghian, Eleonora Marian, Bogdan Sevastre,
Synthesis, Characterization and Biological Activity of Two New Copper (II) Complexes with N-sulfonamide Ligand,
Revista de Chimie,
Volume 70, Issue 11,
2019,
Pages 4060-4067,
ISSN 2668-8212,
https://doi.org/10.37358/RC.70.19.11.7702.
(https://revistadechimie.ro/Articles.asp?ID=7702)
Keywords: oxidative DNA cleavage; antioxidant capacity; SOD-mimetic activity; cytotoxicity; antibacterial properties

RIS
TY - JOUR
T1 - Synthesis, Characterization and Biological Activity of Two New Copper (II) Complexes with N-sulfonamide Ligand
A1 - Hangan, Adriana Corina
A2 - Vicas, Laura Gratiela
A3 - Stan, Roxana Liana
A4 - Pall, Emoke
A5 - Oprean, Luminita Simona
A6 - Ionescu, Corina Maria Lucia
A7 - Andrei, Sanda
A8 - Berghian, Alexandra Cristina Sevastre
A9 - Marian, Eleonora
A10 - Sevastre, Bogdan
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 11
SP - 4060
EP - 4067
UR - https://doi.org/10.37358/RC.70.19.11.7702
KW - oxidative DNA cleavage
KW - antioxidant capacity
KW - SOD-mimetic activity
KW - cytotoxicity
KW - antibacterial properties
ER -

BibTex
@article{RevCh2019P4060,
author = {Hangan Adriana Corina and Vicas Laura Gratiela and Stan Roxana Liana and Pall Emoke and Oprean Luminita Simona and Ionescu Corina Maria Lucia and Andrei Sanda and Berghian Alexandra Cristina Sevastre and Marian Eleonora and Sevastre Bogdan},
title = {Synthesis, Characterization and Biological Activity of Two New Copper (II) Complexes with N-sulfonamide Ligand},
journal = {Revista de Chimie},
volume = {70},
number = {11},
pages = {4060-4067},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.70.19.11.7702},
url = {https://revistadechimie.ro/Articles.asp?ID=7702}
}

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