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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2019, Volume 70, Issue 12, 4207-4211

https://doi.org/10.37358/RC.19.12.7733

Manuela Arbune, Irina-Magdalena Dumitru, Adrian Beznea, Iulian Dan Cuciureanu, Anca-Adriana Arbune, Silvia Fote

Ten Years of Atazanavir Experience A history page of antiretroviral treatment

Abstract:

Antiretroviral therapy has increased the life expectancy and quality of life of patients infected with human immunodeficiency virus (HIV). Antiretroviral therapies based on Atazanavir were preferred for a while, but the recommendations have been changed, once new more effective antiretroviral drugs become available. This study evaluates the experience of using Atazanavir for 10 years in 60 HIV patients, of which 26.6% received the first antiretroviral line and 73.3% had previously received other therapies. The mean duration of exposure to Atazanavir was 4.5 years with variations between 0 and 10 years, with 43.3% of patients still continuing therapy in 2019.Hyperbilirubinemia was identified in 81.6% of patients experiencing ATV. A large proportion of patients discontinued therapy because of their jaundice or lack of adherence, although no significant adverse effects were seen. The effectiveness of ATV has been proven by the sustained immune enhancement and viral suppression, confirming the benefits of maintaining this drug as a therapy option.
Keywords:
Atazanavir; unconjugated hyperbilirubinemia; HIV; HBV

Issue: 2019, Volume 70, Issue 12
Pages: 4207-4211
Publication date: 20/01/2020
https://doi.org/10.37358/RC.19.12.7733
download pdf   Download Pdf Article
Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
ARBUNE, M., DUMITRU, I., BEZNEA, A., CUCIUREANU, I.D., ARBUNE, A., FOTE, S., Ten Years of Atazanavir Experience A history page of antiretroviral treatment, Rev. Chim., 70(12), 2019, 4207-4211.

Vancouver
Arbune M, Dumitru I, Beznea A, Cuciureanu ID, Arbune A, Fote S. Ten Years of Atazanavir Experience A history page of antiretroviral treatment. Rev. Chim.[internet]. 2019 Dec;70(12):4207-4211. Available from: https://doi.org/10.37358/RC.19.12.7733


APA 6th edition
Arbune, M., Dumitru, I., Beznea, A., Cuciureanu, I.D., Arbune, A. & Fote, S. (2019). Ten Years of Atazanavir Experience A history page of antiretroviral treatment. Revista de Chimie, 70(12), 4207-4211. https://doi.org/10.37358/RC.19.12.7733


Harvard
Arbune, M., Dumitru, I., Beznea, A., Cuciureanu, I.D., Arbune, A., Fote, S. (2019). 'Ten Years of Atazanavir Experience A history page of antiretroviral treatment', Revista de Chimie, 70(12), pp. 4207-4211. https://doi.org/10.37358/RC.19.12.7733


IEEE
M. Arbune, I. Dumitru, A. Beznea, I.D. Cuciureanu, A. Arbune, S. Fote, "Ten Years of Atazanavir Experience A history page of antiretroviral treatment". Revista de Chimie, vol. 70, no. 12, pp. 4207-4211, 2019. [online]. https://doi.org/10.37358/RC.19.12.7733


Text
Manuela Arbune, Irina-Magdalena Dumitru, Adrian Beznea, Iulian Dan Cuciureanu, Anca-Adriana Arbune, Silvia Fote,
Ten Years of Atazanavir Experience A history page of antiretroviral treatment,
Revista de Chimie,
Volume 70, Issue 12,
2019,
Pages 4207-4211,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.12.7733.
(https://revistadechimie.ro/Articles.asp?ID=7733)
Keywords: Atazanavir; unconjugated hyperbilirubinemia; HIV; HBV


RIS
TY - JOUR
T1 - Ten Years of Atazanavir Experience A history page of antiretroviral treatment
A1 - Arbune, Manuela
A2 - Dumitru, Irina-Magdalena
A3 - Beznea, Adrian
A4 - Cuciureanu, Iulian Dan
A5 - Arbune, Anca-Adriana
A6 - Fote, Silvia
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 12
SP - 4207
EP - 4211
UR - https://doi.org/10.37358/RC.19.12.7733
KW - Atazanavir
KW - unconjugated hyperbilirubinemia
KW - HIV
KW - HBV
ER -


BibTex
@article{RevCh2019P4207,
author = {Arbune Manuela and Dumitru Irina-Magdalena and Beznea Adrian and Cuciureanu Iulian Dan and Arbune Anca-Adriana and Fote Silvia},
title = {Ten Years of Atazanavir Experience A history page of antiretroviral treatment},
journal = {Revista de Chimie},
volume = {70},
number = {12},
pages = {4207-4211},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.12.7733},
url = {https://revistadechimie.ro/Articles.asp?ID=7733}
}
 
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