Manuela Arbune, Irina-Magdalena Dumitru, Adrian Beznea, Iulian Dan Cuciureanu, Anca-Adriana Arbune, Silvia Fote
Ten Years of Atazanavir Experience A history page of antiretroviral treatment
Abstract:
Antiretroviral therapy has increased the life expectancy and quality of life of patients infected with human immunodeficiency virus (HIV). Antiretroviral therapies based on Atazanavir were preferred for a while, but the recommendations have been changed, once new more effective antiretroviral drugs become available. This study evaluates the experience of using Atazanavir for 10 years in 60 HIV patients, of which 26.6% received the first antiretroviral line and 73.3% had previously received other therapies. The mean duration of exposure to Atazanavir was 4.5 years with variations between 0 and 10 years, with 43.3% of patients still continuing therapy in 2019.Hyperbilirubinemia was identified in 81.6% of patients experiencing ATV. A large proportion of patients discontinued therapy because of their jaundice or lack of adherence, although no significant adverse effects were seen. The effectiveness of ATV has been proven by the sustained immune enhancement and viral suppression, confirming the benefits of maintaining this drug as a therapy option.
Cite this article as: ARBUNE, M., DUMITRU, I., BEZNEA, A., CUCIUREANU, I.D., ARBUNE, A., FOTE, S., Ten Years of Atazanavir Experience A history page of antiretroviral treatment, Rev. Chim., 70(12), 2019, 4207-4211.
Vancouver Arbune M, Dumitru I, Beznea A, Cuciureanu ID, Arbune A, Fote S. Ten Years of Atazanavir Experience A history page of antiretroviral treatment. Rev. Chim.[internet]. 2019 Dec;70(12):4207-4211. Available from: https://doi.org/10.37358/RC.19.12.7733
APA 6th edition Arbune, M., Dumitru, I., Beznea, A., Cuciureanu, I.D., Arbune, A. & Fote, S. (2019). Ten Years of Atazanavir Experience A history page of antiretroviral treatment. Revista de Chimie, 70(12), 4207-4211. https://doi.org/10.37358/RC.19.12.7733
Harvard Arbune, M., Dumitru, I., Beznea, A., Cuciureanu, I.D., Arbune, A., Fote, S. (2019). 'Ten Years of Atazanavir Experience A history page of antiretroviral treatment', Revista de Chimie, 70(12), pp. 4207-4211. https://doi.org/10.37358/RC.19.12.7733
IEEE M. Arbune, I. Dumitru, A. Beznea, I.D. Cuciureanu, A. Arbune, S. Fote, "Ten Years of Atazanavir Experience A history page of antiretroviral treatment". Revista de Chimie, vol. 70, no. 12, pp. 4207-4211, 2019. [online]. https://doi.org/10.37358/RC.19.12.7733
Text Manuela Arbune, Irina-Magdalena Dumitru, Adrian Beznea, Iulian Dan Cuciureanu, Anca-Adriana Arbune, Silvia Fote, Ten Years of Atazanavir Experience A history page of antiretroviral treatment, Revista de Chimie, Volume 70, Issue 12, 2019, Pages 4207-4211, ISSN 2668-8212, https://doi.org/10.37358/RC.19.12.7733. (https://revistadechimie.ro/Articles.asp?ID=7733) Keywords: Atazanavir; unconjugated hyperbilirubinemia; HIV; HBV
RIS TY - JOUR T1 - Ten Years of Atazanavir Experience A history page of antiretroviral treatment A1 - Arbune, Manuela A2 - Dumitru, Irina-Magdalena A3 - Beznea, Adrian A4 - Cuciureanu, Iulian Dan A5 - Arbune, Anca-Adriana A6 - Fote, Silvia JF - Revista de Chimie JO - Rev. Chim. PB - Revista de Chimie SRL SN - 2668-8212 Y1 - 2019 VL - 70 IS - 12 SP - 4207 EP - 4211 UR - https://doi.org/10.37358/RC.19.12.7733 KW - Atazanavir KW - unconjugated hyperbilirubinemia KW - HIV KW - HBV ER -
BibTex @article{RevCh2019P4207, author = {Arbune Manuela and Dumitru Irina-Magdalena and Beznea Adrian and Cuciureanu Iulian Dan and Arbune Anca-Adriana and Fote Silvia}, title = {Ten Years of Atazanavir Experience A history page of antiretroviral treatment}, journal = {Revista de Chimie}, volume = {70}, number = {12}, pages = {4207-4211}, year = {2019}, issn = {2668-8212}, doi = {https://doi.org/10.37358/RC.19.12.7733}, url = {https://revistadechimie.ro/Articles.asp?ID=7733} }
