Exploration of Insulin Sensitivity, Insulin Resistance, Early Insulin Secretion and β-cell Function, and Their Relationship with Glycated Hemoglobin Level in Normal Weight Patients with Newly Diagnosed Type 2 Diabetes Mellitus

Vesa, Cosmin Mihai; Popa, Amorin Remus; Bungau, Simona; Daina, Lucia Georgeta; Buhas, Camelia; Judea-Pusta, Claudia Teodora; Pasca, Bianca; Dimulescu (Nica), Ioana Alina; Zaha, Dana Carmen

Cosmin Mihai Vesa, Amorin Remus Popa, Simona Bungau, Lucia Georgeta Daina, Camelia Buhas, Claudia Teodora Judea-Pusta, Bianca Pasca, Ioana Alina Dimulescu (Nica), Dana Carmen Zaha

Exploration of Insulin Sensitivity, Insulin Resistance, Early Insulin Secretion and β-cell Function, and Their Relationship with Glycated Hemoglobin Level in Normal Weight Patients with Newly Diagnosed Type 2 Diabetes Mellitus

Abstract:

When discussing insulin resistance and insulin sensitivity, data from literature focuses on obese and overweight patients. In our study on, 110 patients with normal body-mass index with newly diagnosed type 2 diabetes mellitus, with the help of glucose tolerance test, we explored insulin resistance, sensitivity, early insulin secretion and β-cell function assessed by using the following indexes: HOMA-IR, ISI, IGI and HOMA-β. We compared the results from our reference group with a control group of 109 overweight patients with newly diagnosed type 2 diabetes mellitus. Normal weight patients had a statistically significant lower HOMA-IR index than overweight patients (2.65 vs. 3.55, p[0.01), however in both groups HOMA-IR was above the cut-off value of 2.5. HOMA-β was statistically significant lower in normal weight patients than in overweight patients (55.08 vs 65.36, p[0.01). ISI index was in an inverse proportional relationship with HOMA-IR, statistically significant higher in normal weight individuals (5.97 vs.3.48, p[0.01). IGI index was not statistically significant lower in normal weight patients (3.63 vs.3.95, p=0.07). It is important to observe that although they have a normal BMI these patients are insulin-resistant confirming the hypothesis of metabolic obese normal weight patients that develop type 2 diabetes mellitus. The indexes that correlate with HbA1c in normal weight patients, predicting glucose status, are HOMA-β (negative correlation), ISI (positive correlation) and IGI index (negative correlation).

Keywords:
insulin; β-cell; glycated hemoglobin; type 2 diabetes mellitus

Issue: 2019, Volume 70, Issue 12

Pages: 4217-4223

Publication date: 2020/1/20

https://doi.org/10.37358/RC.19.12.7735

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
VESA, C.M., POPA, A.R., BUNGAU, S., DAINA, L.G., BUHAS, C., JUDEA-PUSTA, C.T., PASCA, B., DIMULESCU (NICA), I.A., ZAHA, D.C., Exploration of Insulin Sensitivity, Insulin Resistance, Early Insulin Secretion and β-cell Function, and Their Relationship with Glycated Hemoglobin Level in Normal Weight Patients with Newly Diagnosed Type 2 Diabetes Mellitus, Rev. Chim., 70(12), 2019, 4217-4223.

Vancouver
Vesa CM, Popa AR, Bungau S, Daina LG, Buhas C, Judea-Pusta CT, Pasca B, Dimulescu (Nica) IA, Zaha DC. Exploration of Insulin Sensitivity, Insulin Resistance, Early Insulin Secretion and β-cell Function, and Their Relationship with Glycated Hemoglobin Level in Normal Weight Patients with Newly Diagnosed Type 2 Diabetes Mellitus. Rev. Chim.[internet]. 2019 Dec;70(12):4217-4223. Available from: https://doi.org/10.37358/RC.19.12.7735

APA 6th edition
Vesa, C.M., Popa, A.R., Bungau, S., Daina, L.G., Buhas, C., Judea-Pusta, C.T.,... Zaha, D.C. (2019). Exploration of Insulin Sensitivity, Insulin Resistance, Early Insulin Secretion and β-cell Function, and Their Relationship with Glycated Hemoglobin Level in Normal Weight Patients with Newly Diagnosed Type 2 Diabetes Mellitus. Revista de Chimie, 70(12), 4217-4223. https://doi.org/10.37358/RC.19.12.7735

Harvard
Vesa, C.M., Popa, A.R., Bungau, S., Daina, L.G., Buhas, C., Judea-Pusta, C.T., Pasca, B., Dimulescu (Nica), I.A., Zaha, D.C. (2019). 'Exploration of Insulin Sensitivity, Insulin Resistance, Early Insulin Secretion and β-cell Function, and Their Relationship with Glycated Hemoglobin Level in Normal Weight Patients with Newly Diagnosed Type 2 Diabetes Mellitus', Revista de Chimie, 70(12), pp. 4217-4223. https://doi.org/10.37358/RC.19.12.7735

IEEE
C.M. Vesa, A.R. Popa, S. Bungau, L.G. Daina, C. Buhas, C.T. Judea-Pusta, B. Pasca, I.A. Dimulescu(Nica), D.C. Zaha, "Exploration of Insulin Sensitivity, Insulin Resistance, Early Insulin Secretion and β-cell Function, and Their Relationship with Glycated Hemoglobin Level in Normal Weight Patients with Newly Diagnosed Type 2 Diabetes Mellitus". Revista de Chimie, vol. 70, no. 12, pp. 4217-4223, 2019. [online]. https://doi.org/10.37358/RC.19.12.7735

Text
Cosmin Mihai Vesa, Amorin Remus Popa, Simona Bungau, Lucia Georgeta Daina, Camelia Buhas, Claudia Teodora Judea-Pusta, Bianca Pasca, Ioana Alina Dimulescu(Nica), Dana Carmen Zaha,
Exploration of Insulin Sensitivity, Insulin Resistance, Early Insulin Secretion and β-cell Function, and Their Relationship with Glycated Hemoglobin Level in Normal Weight Patients with Newly Diagnosed Type 2 Diabetes Mellitus,
Revista de Chimie,
Volume 70, Issue 12,
2019,
Pages 4217-4223,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.12.7735.
(https://revistadechimie.ro/Articles.asp?ID=7735)
Keywords: insulin; β-cell; glycated hemoglobin; type 2 diabetes mellitus

RIS
TY - JOUR
T1 - Exploration of Insulin Sensitivity, Insulin Resistance, Early Insulin Secretion and β-cell Function, and Their Relationship with Glycated Hemoglobin Level in Normal Weight Patients with Newly Diagnosed Type 2 Diabetes Mellitus
A1 - Vesa, Cosmin Mihai
A2 - Popa, Amorin Remus
A3 - Bungau, Simona
A4 - Daina, Lucia Georgeta
A5 - Buhas, Camelia
A6 - Judea-Pusta, Claudia Teodora
A7 - Pasca, Bianca
A8 - Dimulescu (Nica), Ioana Alina
A9 - Zaha, Dana Carmen
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 12
SP - 4217
EP - 4223
UR - https://doi.org/10.37358/RC.19.12.7735
KW - insulin
KW - β-cell
KW - glycated hemoglobin
KW - type 2 diabetes mellitus
ER -

BibTex
@article{RevCh2019P4217,
author = {Vesa Cosmin Mihai and Popa Amorin Remus and Bungau Simona and Daina Lucia Georgeta and Buhas Camelia and Judea-Pusta Claudia Teodora and Pasca Bianca and Dimulescu (Nica) Ioana Alina and Zaha Dana Carmen},
title = {Exploration of Insulin Sensitivity, Insulin Resistance, Early Insulin Secretion and β-cell Function, and Their Relationship with Glycated Hemoglobin Level in Normal Weight Patients with Newly Diagnosed Type 2 Diabetes Mellitus},
journal = {Revista de Chimie},
volume = {70},
number = {12},
pages = {4217-4223},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.12.7735},
url = {https://revistadechimie.ro/Articles.asp?ID=7735}
}

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