ABOUT INDEXING BOARD ARCHIVES AUTHOR GUIDELINES SUBMIT PAPER AUTHOR'S PAGE NEWS, EVENTS CONTACT
REVISTA DE CHIMIE
Cite as: Rev. Chim.
https://doi.org/10.37358/Rev.Chim.1949

OSIM Nr. R102355
ISSN Online 2668-8212
ISSN Print: 1582-9049
ISSN-L: 1582-9049

REVISTA DE CHIMIE Latest Issue

LATEST ISSUE >>>

   Volume 74, 2023
   Volume 73, 2022
   Volume 72, 2021
   Volume 71, 2020
   Volume 70, 2019
   Volume 69, 2018
   Volume 68, 2017
   Volume 67, 2016
   Volume 66, 2015
   Volume 65, 2014
   Volume 64, 2013
   Volume 63, 2012
   Volume 62, 2011
   Volume 61, 2010
   Volume 60, 2009
   Volume 59, 2008
   Volume 58, 2007
 
<<<< back

Revista de Chimie (Rev. Chim.), Year 2019, Volume 70, Issue 12, 4244-4247

https://doi.org/10.37358/RC.19.12.7740

Ileana Ramona Barac, Cristina Veronica Andreescu, Razvan Petca, Claudia Mehedintu, Aida Petca, Alec Ionescu, Mihaela Marian, Florian Balta

Leber Hereditary Optic Neuropathy - Idebenone, Hope of Treatment

Abstract:

Leber hereditary optical neuropathy (LHON) is part of the class of optic neuropathies in which the mitochondrial function is impaired and is characterized by a painless, subacute, bilateral decrease of the central vision. We shall present the case of two brothers AM aged 31 and AT aged 40 who were diagnosed with LHON and whom we initiated treatment with idebenone 900 mg / day with monitoring at one month and 6 months. The mitochondrial DNA analysis demonstrated the existence of mutations 11778G]A for the mtND4 gene in both patients. Idebenone is a synthetic benzoquinone, analogue of ubiquinone. We found a slight but significant improvement in the visual field in patient AM at one month of treatment. We have not found another case in the literature with an improvement in vision so fast after this treatment, and this has led us to write this article.
Keywords:

Leber hereditary optical neuropathy (LHON); idebenone; mutations 11778G>A; mtND4 gene

Issue: 2019, Volume 70, Issue 12
Pages: 4244-4247
Publication date: 2020/1/20
https://doi.org/10.37358/RC.19.12.7740
download pdf   Download Pdf Article
Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
BARAC, I.R., ANDREESCU, C.V., PETCA, R., MEHEDINTU, C., PETCA, A., IONESCU, A., MARIAN, M., BALTA, F., Leber Hereditary Optic Neuropathy - Idebenone, Hope of Treatment, Rev. Chim., 70(12), 2019, 4244-4247.

Vancouver
Barac IR, Andreescu CV, Petca R, Mehedintu C, Petca A, Ionescu A, Marian M, Balta F. Leber Hereditary Optic Neuropathy - Idebenone, Hope of Treatment. Rev. Chim.[internet]. 2019 Dec;70(12):4244-4247. Available from: https://doi.org/10.37358/RC.19.12.7740


APA 6th edition
Barac, I.R., Andreescu, C.V., Petca, R., Mehedintu, C., Petca, A., Ionescu, A., Marian, M. & Balta, F. (2019). Leber Hereditary Optic Neuropathy - Idebenone, Hope of Treatment. Revista de Chimie, 70(12), 4244-4247. https://doi.org/10.37358/RC.19.12.7740


Harvard
Barac, I.R., Andreescu, C.V., Petca, R., Mehedintu, C., Petca, A., Ionescu, A., Marian, M., Balta, F. (2019). 'Leber Hereditary Optic Neuropathy - Idebenone, Hope of Treatment', Revista de Chimie, 70(12), pp. 4244-4247. https://doi.org/10.37358/RC.19.12.7740


IEEE
I.R. Barac, C.V. Andreescu, R. Petca, C. Mehedintu, A. Petca, A. Ionescu, M. Marian, F. Balta, "Leber Hereditary Optic Neuropathy - Idebenone, Hope of Treatment". Revista de Chimie, vol. 70, no. 12, pp. 4244-4247, 2019. [online]. https://doi.org/10.37358/RC.19.12.7740


Text
Ileana Ramona Barac, Cristina Veronica Andreescu, Razvan Petca, Claudia Mehedintu, Aida Petca, Alec Ionescu, Mihaela Marian, Florian Balta,
Leber Hereditary Optic Neuropathy - Idebenone, Hope of Treatment,
Revista de Chimie,
Volume 70, Issue 12,
2019,
Pages 4244-4247,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.12.7740.
(https://revistadechimie.ro/Articles.asp?ID=7740)
Keywords:
Leber hereditary optical neuropathy (LHON); idebenone; mutations 11778G>A; mtND4 gene


RIS
TY - JOUR
T1 - Leber Hereditary Optic Neuropathy - Idebenone, Hope of Treatment
A1 - Barac, Ileana Ramona
A2 - Andreescu, Cristina Veronica
A3 - Petca, Razvan
A4 - Mehedintu, Claudia
A5 - Petca, Aida
A6 - Ionescu, Alec
A7 - Marian, Mihaela
A8 - Balta, Florian
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 12
SP - 4244
EP - 4247
UR - https://doi.org/10.37358/RC.19.12.7740
KW -
Leber hereditary optical neuropathy (LHON)
KW - idebenone
KW - mutations 11778G>A
KW - mtND4 gene
ER -


BibTex
@article{RevCh2019P4244,
author = {Barac Ileana Ramona and Andreescu Cristina Veronica and Petca Razvan and Mehedintu Claudia and Petca Aida and Ionescu Alec and Marian Mihaela and Balta Florian},
title = {Leber Hereditary Optic Neuropathy - Idebenone, Hope of Treatment},
journal = {Revista de Chimie},
volume = {70},
number = {12},
pages = {4244-4247},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.12.7740},
url = {https://revistadechimie.ro/Articles.asp?ID=7740}
}
 
<<<< back
 
PUBLISHING SECTION
Author Guidelines
 * Paper Drafting
 * Paper Template
 * Ethical Statement
 * Paper Submission
Ghidul Autorului (ro)
Submit Paper
Author's Page
Publishing Ethics
Peer Review Process
Open Access & Archiving Policy
 Search Authors
 LATEST NEWS
REvista de Chimie NUMAR OMAGIAL PETRU PONI.. detalii
REvista de Chimie Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
dictionar English-Romanian Dictionary for Mechanical Engineering
(download pdf)
  News, Events
Crossref Member Badge
 DOI  logo
 Gold Open Access | Source=http://www.plos.org/  | Author=art designer at PLoS
Creative Commons License
 Conferences of Contemporary
 Chemistry
 Biblioteca Chimiei
 Materiale Plastice