Leber Hereditary Optic Neuropathy - Idebenone, Hope of Treatment

Barac, Ileana Ramona; Andreescu, Cristina Veronica; Petca, Razvan; Mehedintu, Claudia; Petca, Aida; Ionescu, Alec; Marian, Mihaela; Balta, Florian

Ileana Ramona Barac, Cristina Veronica Andreescu, Razvan Petca, Claudia Mehedintu, Aida Petca, Alec Ionescu, Mihaela Marian, Florian Balta

Leber Hereditary Optic Neuropathy - Idebenone, Hope of Treatment

Abstract:

Leber hereditary optical neuropathy (LHON) is part of the class of optic neuropathies in which the mitochondrial function is impaired and is characterized by a painless, subacute, bilateral decrease of the central vision. We shall present the case of two brothers AM aged 31 and AT aged 40 who were diagnosed with LHON and whom we initiated treatment with idebenone 900 mg / day with monitoring at one month and 6 months. The mitochondrial DNA analysis demonstrated the existence of mutations 11778G]A for the mtND4 gene in both patients. Idebenone is a synthetic benzoquinone, analogue of ubiquinone. We found a slight but significant improvement in the visual field in patient AM at one month of treatment. We have not found another case in the literature with an improvement in vision so fast after this treatment, and this has led us to write this article.

Keywords:

Leber hereditary optical neuropathy (LHON); idebenone; mutations 11778G>A; mtND4 gene

Issue: 2019, Volume 70, Issue 12

Pages: 4244-4247

Publication date: 2020/1/20

https://doi.org/10.37358/RC.19.12.7740

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
BARAC, I.R., ANDREESCU, C.V., PETCA, R., MEHEDINTU, C., PETCA, A., IONESCU, A., MARIAN, M., BALTA, F., Leber Hereditary Optic Neuropathy - Idebenone, Hope of Treatment, Rev. Chim., 70(12), 2019, 4244-4247.

Vancouver
Barac IR, Andreescu CV, Petca R, Mehedintu C, Petca A, Ionescu A, Marian M, Balta F. Leber Hereditary Optic Neuropathy - Idebenone, Hope of Treatment. Rev. Chim.[internet]. 2019 Dec;70(12):4244-4247. Available from: https://doi.org/10.37358/RC.19.12.7740

APA 6th edition
Barac, I.R., Andreescu, C.V., Petca, R., Mehedintu, C., Petca, A., Ionescu, A., Marian, M. & Balta, F. (2019). Leber Hereditary Optic Neuropathy - Idebenone, Hope of Treatment. Revista de Chimie, 70(12), 4244-4247. https://doi.org/10.37358/RC.19.12.7740

Harvard
Barac, I.R., Andreescu, C.V., Petca, R., Mehedintu, C., Petca, A., Ionescu, A., Marian, M., Balta, F. (2019). 'Leber Hereditary Optic Neuropathy - Idebenone, Hope of Treatment', Revista de Chimie, 70(12), pp. 4244-4247. https://doi.org/10.37358/RC.19.12.7740

IEEE
I.R. Barac, C.V. Andreescu, R. Petca, C. Mehedintu, A. Petca, A. Ionescu, M. Marian, F. Balta, "Leber Hereditary Optic Neuropathy - Idebenone, Hope of Treatment". Revista de Chimie, vol. 70, no. 12, pp. 4244-4247, 2019. [online]. https://doi.org/10.37358/RC.19.12.7740

Text
Ileana Ramona Barac, Cristina Veronica Andreescu, Razvan Petca, Claudia Mehedintu, Aida Petca, Alec Ionescu, Mihaela Marian, Florian Balta,
Leber Hereditary Optic Neuropathy - Idebenone, Hope of Treatment,
Revista de Chimie,
Volume 70, Issue 12,
2019,
Pages 4244-4247,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.12.7740.
(https://revistadechimie.ro/Articles.asp?ID=7740)
Keywords:
Leber hereditary optical neuropathy (LHON); idebenone; mutations 11778G>A; mtND4 gene

RIS
TY - JOUR
T1 - Leber Hereditary Optic Neuropathy - Idebenone, Hope of Treatment
A1 - Barac, Ileana Ramona
A2 - Andreescu, Cristina Veronica
A3 - Petca, Razvan
A4 - Mehedintu, Claudia
A5 - Petca, Aida
A6 - Ionescu, Alec
A7 - Marian, Mihaela
A8 - Balta, Florian
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 12
SP - 4244
EP - 4247
UR - https://doi.org/10.37358/RC.19.12.7740
KW -
Leber hereditary optical neuropathy (LHON)
KW - idebenone
KW - mutations 11778G>A
KW - mtND4 gene
ER -

BibTex
@article{RevCh2019P4244,
author = {Barac Ileana Ramona and Andreescu Cristina Veronica and Petca Razvan and Mehedintu Claudia and Petca Aida and Ionescu Alec and Marian Mihaela and Balta Florian},
title = {Leber Hereditary Optic Neuropathy - Idebenone, Hope of Treatment},
journal = {Revista de Chimie},
volume = {70},
number = {12},
pages = {4244-4247},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.12.7740},
url = {https://revistadechimie.ro/Articles.asp?ID=7740}
}

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