Cholinergic Enhancing and Antioxidant Effect of Vigna subterranea (L.) Verdc. (Fabaceae) Landrace Aqueous Extract on Scopolamine-Induced Amnesia in Male Swiss Mice

Abaissou, Hervé Hervé Ngatanko; Simplice, Foyet Harquin; Wado, Eglantine Keugong; Nkwingwa, Balbine Kamleu; Kamda, Jorelle Linda Damo; Djomessie, Lea Blondelle Kenko; Poroch, Vladimir; Dobrin, Irina; Bum, Elisabeth Ngo; Dobrin, Petru Romeo; Bolos, Alexandra; Cristofor, Ana-Caterina

Hervé Hervé Ngatanko Abaissou, Foyet Harquin Simplice, Eglantine Keugong Wado, Balbine Kamleu Nkwingwa, Jorelle Linda Damo Kamda, Lea Blondelle Kenko Djomessie, Vladimir Poroch, Irina Dobrin, Elisabeth Ngo Bum, Petru Romeo Dobrin, Alexandra Bolos, Ana-Caterina Cristofor

Cholinergic Enhancing and Antioxidant Effect of Vigna subterranea (L.) Verdc. (Fabaceae) Landrace Aqueous Extract on Scopolamine-Induced Amnesia in Male Swiss Mice

Abstract:

The present study was conducted to investigate protective effects of the aqueous extract of V. subterranea seeds landrace on amnesia induced by scopolamine in mice. V. subterranea aqueous extract (100, 200 and 400 mg/kg BW) was administered by gavage for nine consecutive days and memory impairment was induced by repeated intraperitoneal injection of scopolamine (1.5 mg/kg). The Y-maze (YM), Morris water maze (MWM), novel object recognition paradigm (NOR) and the T maze (TM) were used to assess learning, memory and retention. Superoxide dismutase (SOD), Catalase (CAT), Malondialdehyde (MDA) levels and Acetylcholine esterase activity was also evaluated in the mice hippocampi homogenates. V. subterranea aqueous extract (400 mg/kg) significantly increased the percentage of spontaneous alternation in the YM task and decreased escape latency in the MWM. Moreover, this dose brought about a significantly improvement in the time spent in the preferred TM arm and discrimination index in the NOR tasks despite repeated scopolamine injection. Additionally, low acetylcholine esterase levels, reduced lipid peroxidation (malondialdehyde) but increased antioxidant enzymes (catalase and superoxide dismutase) activity was observed in hippocampi homogenate of mice pre-treated with the extract. A protective action against hippocampal cell damage was also evident. This finding suggests that the aqueous extract of V. subterranea seed landrace may improve learning and memory.

Keywords:
Vigna subterranea; Alzheimer’s disease; Memory impairment; Scopolamine; Antioxidant; Acetylcholine esterase

Issue: 2019, Volume 70, Issue 12

Pages: 4336-4347

Publication date: 2020/1/20

https://doi.org/10.37358/RC.19.12.7755

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
ABAISSOU, H.H.N., SIMPLICE, F.H., WADO, E.K., NKWINGWA, B.K., KAMDA, J.L.D., DJOMESSIE, L.B.K., POROCH, V., DOBRIN, I., BUM, E.N., DOBRIN, P.R., BOLOS, A., CRISTOFOR, A., Cholinergic Enhancing and Antioxidant Effect of Vigna subterranea (L.) Verdc. (Fabaceae) Landrace Aqueous Extract on Scopolamine-Induced Amnesia in Male Swiss Mice, Rev. Chim., 70(12), 2019, 4336-4347.

Vancouver
Abaissou HHN, Simplice FH, Wado EK, Nkwingwa BK, Kamda JLD, Djomessie LBK, Poroch V, Dobrin I, Bum EN, Dobrin PR, Bolos A, Cristofor A. Cholinergic Enhancing and Antioxidant Effect of Vigna subterranea (L.) Verdc. (Fabaceae) Landrace Aqueous Extract on Scopolamine-Induced Amnesia in Male Swiss Mice. Rev. Chim.[internet]. 2019 Dec;70(12):4336-4347. Available from: https://doi.org/10.37358/RC.19.12.7755

APA 6th edition
Abaissou, H.H.N., Simplice, F.H., Wado, E.K., Nkwingwa, B.K., Kamda, J.L.D., Djomessie, L.B.K.,... Cristofor, A. (2019). Cholinergic Enhancing and Antioxidant Effect of Vigna subterranea (L.) Verdc. (Fabaceae) Landrace Aqueous Extract on Scopolamine-Induced Amnesia in Male Swiss Mice. Revista de Chimie, 70(12), 4336-4347. https://doi.org/10.37358/RC.19.12.7755

Harvard
Abaissou, H.H.N., Simplice, F.H., Wado, E.K., Nkwingwa, B.K., Kamda, J.L.D., Djomessie, L.B.K., Poroch, V., Dobrin, I., Bum, E.N., Dobrin, P.R., Bolos, A., Cristofor, A. (2019). 'Cholinergic Enhancing and Antioxidant Effect of Vigna subterranea (L.) Verdc. (Fabaceae) Landrace Aqueous Extract on Scopolamine-Induced Amnesia in Male Swiss Mice', Revista de Chimie, 70(12), pp. 4336-4347. https://doi.org/10.37358/RC.19.12.7755

IEEE
H.H.N. Abaissou, F.H. Simplice, E.K. Wado, B.K. Nkwingwa, J.L.D. Kamda, L.B.K. Djomessie, V. Poroch, I. Dobrin, E.N. Bum, P.R. Dobrin, A. Bolos, A. Cristofor, "Cholinergic Enhancing and Antioxidant Effect of Vigna subterranea (L.) Verdc. (Fabaceae) Landrace Aqueous Extract on Scopolamine-Induced Amnesia in Male Swiss Mice". Revista de Chimie, vol. 70, no. 12, pp. 4336-4347, 2019. [online]. https://doi.org/10.37358/RC.19.12.7755

Text
Hervé Hervé Ngatanko Abaissou, Foyet Harquin Simplice, Eglantine Keugong Wado, Balbine Kamleu Nkwingwa, Jorelle Linda Damo Kamda, Lea Blondelle Kenko Djomessie, Vladimir Poroch, Irina Dobrin, Elisabeth Ngo Bum, Petru Romeo Dobrin, Alexandra Bolos, Ana-Caterina Cristofor,
Cholinergic Enhancing and Antioxidant Effect of Vigna subterranea (L.) Verdc. (Fabaceae) Landrace Aqueous Extract on Scopolamine-Induced Amnesia in Male Swiss Mice,
Revista de Chimie,
Volume 70, Issue 12,
2019,
Pages 4336-4347,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.12.7755.
(https://revistadechimie.ro/Articles.asp?ID=7755)
Keywords: Vigna subterranea; Alzheimer’s disease; Memory impairment; Scopolamine; Antioxidant; Acetylcholine esterase

RIS
TY - JOUR
T1 - Cholinergic Enhancing and Antioxidant Effect of Vigna subterranea (L.) Verdc. (Fabaceae) Landrace Aqueous Extract on Scopolamine-Induced Amnesia in Male Swiss Mice
A1 - Abaissou, Hervé Hervé Ngatanko
A2 - Simplice, Foyet Harquin
A3 - Wado, Eglantine Keugong
A4 - Nkwingwa, Balbine Kamleu
A5 - Kamda, Jorelle Linda Damo
A6 - Djomessie, Lea Blondelle Kenko
A7 - Poroch, Vladimir
A8 - Dobrin, Irina
A9 - Bum, Elisabeth Ngo
A10 - Dobrin, Petru Romeo
A11 - Bolos, Alexandra
A12 - Cristofor, Ana-Caterina
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 12
SP - 4336
EP - 4347
UR - https://doi.org/10.37358/RC.19.12.7755
KW - Vigna subterranea
KW - Alzheimer’s disease
KW - Memory impairment
KW - Scopolamine
KW - Antioxidant
KW - Acetylcholine esterase
ER -

BibTex
@article{RevCh2019P4336,
author = {Abaissou Hervé Hervé Ngatanko and Simplice Foyet Harquin and Wado Eglantine Keugong and Nkwingwa Balbine Kamleu and Kamda Jorelle Linda Damo and Djomessie Lea Blondelle Kenko and Poroch Vladimir and Dobrin Irina and Bum Elisabeth Ngo and Dobrin Petru Romeo and Bolos Alexandra and Cristofor Ana-Caterina},
title = {Cholinergic Enhancing and Antioxidant Effect of Vigna subterranea (L.) Verdc. (Fabaceae) Landrace Aqueous Extract on Scopolamine-Induced Amnesia in Male Swiss Mice},
journal = {Revista de Chimie},
volume = {70},
number = {12},
pages = {4336-4347},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.12.7755},
url = {https://revistadechimie.ro/Articles.asp?ID=7755}
}

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