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REVISTA DE CHIMIE
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https://doi.org/10.37358/Rev.Chim.1949

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ISSN Print 0034-7752
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Revista de Chimie (Rev. Chim.), Year 2019, Volume 70, Issue 12, 4348-4353

https://doi.org/10.37358/RC.19.12.7756

Doina Butcovan, Grigore Tinica, Cristian Statescu, Daniel Timofte, Bogdan Ciuntu, Radu Sascau, Rodica Radu, Larisa Anghel, Mihaela Carmina Schaas, Codruta Badescu, Raoul Vasile Lupusoru

Immunohistochemical Interplay in Associated Large Vessel Vasculitis and consequent Ascending Aortic Aneurysm and Review of Literature

Abstract:

Large vessel vasculitis (LVV), such as giant cell arteritis (GCA) and Takayasu’s arteritis (TA), are autoimmune diseases characterized by granulomatous inflammation of large vessels, including the aorta and its branch vessels. Disease etiology is still unknown. Comparative immunohistochemical (IMH) studies between GCA and TA cases might be important. The purpose of the study was to assess and to compare composition and distribution of the inflammatory infiltrate of the ascending aortic aneurysmal wall. Ascending aortic aneurysm (AAA) tissue blocks belonging to one male patient of 59 years and one female patient aged 36 years, diagnosed with GCA and TA, respectively, were used for histological and IMH analysis. Immunohistochemistry staining was performed using antibodies directed against markers of lymphocytes and macrophages. Histological analysis showed in both cases lymphocytes, macrophages, epithelioid histiocytes and multinucleated giant cells that infiltrate all layers of the arterial wall, intimal hyperplasia and adventitial fibrotic changes of different degrees. Immunohistochemical examination showed that the media and adventitia from GCA aortitis case had increased number of T cells and macrophages compared with TA aortitis case, and a less number of B cells in both. Our study made a morphologic and morphometric analysis of lymphocyte infiltration within aneurysm aortic tissue and demonstrated that immune inflammation is a typical feature of GCA and TA diseases. We also noted the utility of immunohistochemical staining of the aortic biopsies for evaluation of indeterminate or healing GCA and TA cases.
Keywords:
immunohistochemical; granulomatous inflammation; aortic aneurysm; large vessel vasculitis

Issue: 2019, Volume 70, Issue 12
Pages: 4348-4353
Publication date: 20/01/2020
https://doi.org/10.37358/RC.19.12.7756
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
BUTCOVAN, D., TINICA, G., STATESCU, C., TIMOFTE, D., CIUNTU, B., SASCAU, R., RADU, R., ANGHEL, L., SCHAAS, M.C., BADESCU, C., LUPUSORU, R.V., Immunohistochemical Interplay in Associated Large Vessel Vasculitis and consequent Ascending Aortic Aneurysm and Review of Literature, Rev. Chim., 70(12), 2019, 4348-4353.

Vancouver
Butcovan D, Tinica G, Statescu C, Timofte D, Ciuntu B, Sascau R, Radu R, Anghel L, Schaas MC, Badescu C, Lupusoru RV. Immunohistochemical Interplay in Associated Large Vessel Vasculitis and consequent Ascending Aortic Aneurysm and Review of Literature. Rev. Chim.[internet]. 2019 Dec;70(12):4348-4353. Available from: https://doi.org/10.37358/RC.19.12.7756


APA 6th edition
Butcovan, D., Tinica, G., Statescu, C., Timofte, D., Ciuntu, B., Sascau, R.,... Lupusoru, R.V. (2019). Immunohistochemical Interplay in Associated Large Vessel Vasculitis and consequent Ascending Aortic Aneurysm and Review of Literature. Revista de Chimie, 70(12), 4348-4353. https://doi.org/10.37358/RC.19.12.7756


Harvard
Butcovan, D., Tinica, G., Statescu, C., Timofte, D., Ciuntu, B., Sascau, R., Radu, R., Anghel, L., Schaas, M.C., Badescu, C., Lupusoru, R.V. (2019). 'Immunohistochemical Interplay in Associated Large Vessel Vasculitis and consequent Ascending Aortic Aneurysm and Review of Literature', Revista de Chimie, 70(12), pp. 4348-4353. https://doi.org/10.37358/RC.19.12.7756


IEEE
D. Butcovan, G. Tinica, C. Statescu, D. Timofte, B. Ciuntu, R. Sascau, R. Radu, L. Anghel, M.C. Schaas, C. Badescu, R.V. Lupusoru, "Immunohistochemical Interplay in Associated Large Vessel Vasculitis and consequent Ascending Aortic Aneurysm and Review of Literature". Revista de Chimie, vol. 70, no. 12, pp. 4348-4353, 2019. [online]. https://doi.org/10.37358/RC.19.12.7756


Text
Doina Butcovan, Grigore Tinica, Cristian Statescu, Daniel Timofte, Bogdan Ciuntu, Radu Sascau, Rodica Radu, Larisa Anghel, Mihaela Carmina Schaas, Codruta Badescu, Raoul Vasile Lupusoru,
Immunohistochemical Interplay in Associated Large Vessel Vasculitis and consequent Ascending Aortic Aneurysm and Review of Literature,
Revista de Chimie,
Volume 70, Issue 12,
2019,
Pages 4348-4353,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.12.7756.
(https://revistadechimie.ro/Articles.asp?ID=7756)
Keywords: immunohistochemical; granulomatous inflammation; aortic aneurysm; large vessel vasculitis


RIS
TY - JOUR
T1 - Immunohistochemical Interplay in Associated Large Vessel Vasculitis and consequent Ascending Aortic Aneurysm and Review of Literature
A1 - Butcovan, Doina
A2 - Tinica, Grigore
A3 - Statescu, Cristian
A4 - Timofte, Daniel
A5 - Ciuntu, Bogdan
A6 - Sascau, Radu
A7 - Radu, Rodica
A8 - Anghel, Larisa
A9 - Schaas, Mihaela Carmina
A10 - Badescu, Codruta
A11 - Lupusoru, Raoul Vasile
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 12
SP - 4348
EP - 4353
UR - https://doi.org/10.37358/RC.19.12.7756
KW - immunohistochemical
KW - granulomatous inflammation
KW - aortic aneurysm
KW - large vessel vasculitis
ER -


BibTex
@article{RevCh2019P4348,
author = {Butcovan Doina and Tinica Grigore and Statescu Cristian and Timofte Daniel and Ciuntu Bogdan and Sascau Radu and Radu Rodica and Anghel Larisa and Schaas Mihaela Carmina and Badescu Codruta and Lupusoru Raoul Vasile},
title = {Immunohistochemical Interplay in Associated Large Vessel Vasculitis and consequent Ascending Aortic Aneurysm and Review of Literature},
journal = {Revista de Chimie},
volume = {70},
number = {12},
pages = {4348-4353},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.12.7756},
url = {https://revistadechimie.ro/Articles.asp?ID=7756}
}
 
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