ESR Spectroscopy Insight on the Anticancer Drug Mitoxantrone Location in Membrane Mimetic Systems
Abstract:
The location of mitoxantrone molecule in micelles formed by bile salts (sodium taurocholate (NaTC) and sodium taurodeoxycholate (NaTDC)) and sodium dodecyl sulfate (SDS) have been investigated by electron spin resonance (ESR) spectroscopy, using three doxylstearic acid probes (5-, 12- and 16-doxylstearic acid abbreviated as 5-DSA, 12-DSA and 16-DSA). The analysis of ESR parameters of these spin probes evidenced slower dynamics induced by mitoxantrone that vary in the following order: 12-DSA ] 5-DSA ] 16-DSA for both bile salts micelles and 5-DSA ] 12-DSA ] 16-DSA for SDS micelles. The ESR parameters are slightly sensitive to variation of pH. These results indicate that the spin probes target different regions in these aggregates.
Keywords: mitoxantrone; bile salts micelles; SDS micelles; ESR spectroscopy
Cite this article as: ENACHE, M., IONITA, G., ESR Spectroscopy Insight on the Anticancer Drug Mitoxantrone Location in Membrane Mimetic Systems, Rev. Chim., 70(12), 2019, 4354-4359.
Vancouver Enache M, Ionita G. ESR Spectroscopy Insight on the Anticancer Drug Mitoxantrone Location in Membrane Mimetic Systems. Rev. Chim.[internet]. 2019 Dec;70(12):4354-4359. Available from: https://doi.org/10.37358/RC.19.12.7757
APA 6th edition Enache, M., Ionita, G. (2019). ESR Spectroscopy Insight on the Anticancer Drug Mitoxantrone Location in Membrane Mimetic Systems. Revista de Chimie, 70(12), 4354-4359. https://doi.org/10.37358/RC.19.12.7757
Harvard Enache, M., Ionita, G. (2019). 'ESR Spectroscopy Insight on the Anticancer Drug Mitoxantrone Location in Membrane Mimetic Systems', Revista de Chimie, 70(12), pp. 4354-4359. https://doi.org/10.37358/RC.19.12.7757
IEEE M. Enache, G. Ionita, "ESR Spectroscopy Insight on the Anticancer Drug Mitoxantrone Location in Membrane Mimetic Systems". Revista de Chimie, vol. 70, no. 12, pp. 4354-4359, 2019. [online]. https://doi.org/10.37358/RC.19.12.7757
Text Mirela Enache, Gabriela Ionita, ESR Spectroscopy Insight on the Anticancer Drug Mitoxantrone Location in Membrane Mimetic Systems, Revista de Chimie, Volume 70, Issue 12, 2019, Pages 4354-4359, ISSN 2668-8212, https://doi.org/10.37358/RC.19.12.7757. (https://revistadechimie.ro/Articles.asp?ID=7757) Keywords: mitoxantrone; bile salts micelles; SDS micelles; ESR spectroscopy
RIS TY - JOUR T1 - ESR Spectroscopy Insight on the Anticancer Drug Mitoxantrone Location in Membrane Mimetic Systems A1 - Enache, Mirela A2 - Ionita, Gabriela JF - Revista de Chimie JO - Rev. Chim. PB - Revista de Chimie SRL SN - 2668-8212 Y1 - 2019 VL - 70 IS - 12 SP - 4354 EP - 4359 UR - https://doi.org/10.37358/RC.19.12.7757 KW - mitoxantrone KW - bile salts micelles KW - SDS micelles KW - ESR spectroscopy
ER -
BibTex @article{RevCh2019P4354, author = {Enache Mirela and Ionita Gabriela}, title = {ESR Spectroscopy Insight on the Anticancer Drug Mitoxantrone Location in Membrane Mimetic Systems}, journal = {Revista de Chimie}, volume = {70}, number = {12}, pages = {4354-4359}, year = {2019}, issn = {2668-8212}, doi = {https://doi.org/10.37358/RC.19.12.7757}, url = {https://revistadechimie.ro/Articles.asp?ID=7757} }
