ESR Spectroscopy Insight on the Anticancer Drug Mitoxantrone Location in Membrane Mimetic Systems

Enache, Mirela; Ionita, Gabriela

Mirela Enache, Gabriela Ionita

ESR Spectroscopy Insight on the Anticancer Drug Mitoxantrone Location in Membrane Mimetic Systems

Abstract:

The location of mitoxantrone molecule in micelles formed by bile salts (sodium taurocholate (NaTC) and sodium taurodeoxycholate (NaTDC)) and sodium dodecyl sulfate (SDS) have been investigated by electron spin resonance (ESR) spectroscopy, using three doxylstearic acid probes (5-, 12- and 16-doxylstearic acid abbreviated as 5-DSA, 12-DSA and 16-DSA). The analysis of ESR parameters of these spin probes evidenced slower dynamics induced by mitoxantrone that vary in the following order: 12-DSA ] 5-DSA ] 16-DSA for both bile salts micelles and 5-DSA ] 12-DSA ] 16-DSA for SDS micelles. The ESR parameters are slightly sensitive to variation of pH. These results indicate that the spin probes target different regions in these aggregates.

Keywords:
mitoxantrone; bile salts micelles; SDS micelles; ESR spectroscopy

Issue: 2019, Volume 70, Issue 12

Pages: 4354-4359

Publication date: 2020/1/20

https://doi.org/10.37358/RC.19.12.7757

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
ENACHE, M., IONITA, G., ESR Spectroscopy Insight on the Anticancer Drug Mitoxantrone Location in Membrane Mimetic Systems, Rev. Chim., 70(12), 2019, 4354-4359.

Vancouver
Enache M, Ionita G. ESR Spectroscopy Insight on the Anticancer Drug Mitoxantrone Location in Membrane Mimetic Systems. Rev. Chim.[internet]. 2019 Dec;70(12):4354-4359. Available from: https://doi.org/10.37358/RC.19.12.7757

APA 6th edition
Enache, M., Ionita, G. (2019). ESR Spectroscopy Insight on the Anticancer Drug Mitoxantrone Location in Membrane Mimetic Systems. Revista de Chimie, 70(12), 4354-4359. https://doi.org/10.37358/RC.19.12.7757

Harvard
Enache, M., Ionita, G. (2019). 'ESR Spectroscopy Insight on the Anticancer Drug Mitoxantrone Location in Membrane Mimetic Systems', Revista de Chimie, 70(12), pp. 4354-4359. https://doi.org/10.37358/RC.19.12.7757

IEEE
M. Enache, G. Ionita, "ESR Spectroscopy Insight on the Anticancer Drug Mitoxantrone Location in Membrane Mimetic Systems". Revista de Chimie, vol. 70, no. 12, pp. 4354-4359, 2019. [online]. https://doi.org/10.37358/RC.19.12.7757

Text
Mirela Enache, Gabriela Ionita,
ESR Spectroscopy Insight on the Anticancer Drug Mitoxantrone Location in Membrane Mimetic Systems,
Revista de Chimie,
Volume 70, Issue 12,
2019,
Pages 4354-4359,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.12.7757.
(https://revistadechimie.ro/Articles.asp?ID=7757)
Keywords: mitoxantrone; bile salts micelles; SDS micelles; ESR spectroscopy

RIS
TY - JOUR
T1 - ESR Spectroscopy Insight on the Anticancer Drug Mitoxantrone Location in Membrane Mimetic Systems
A1 - Enache, Mirela
A2 - Ionita, Gabriela
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 12
SP - 4354
EP - 4359
UR - https://doi.org/10.37358/RC.19.12.7757
KW - mitoxantrone
KW - bile salts micelles
KW - SDS micelles
KW - ESR spectroscopy

ER -

BibTex
@article{RevCh2019P4354,
author = {Enache Mirela and Ionita Gabriela},
title = {ESR Spectroscopy Insight on the Anticancer Drug Mitoxantrone Location in Membrane Mimetic Systems},
journal = {Revista de Chimie},
volume = {70},
number = {12},
pages = {4354-4359},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.12.7757},
url = {https://revistadechimie.ro/Articles.asp?ID=7757}
}

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