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Revista de Chimie (Rev. Chim.), Year 2019, Volume 70, Issue 12, 4393-4399

https://doi.org/10.37358/RC.19.12.7764

Tiberiu Adelmann, Nela Pusa Gaje, Laura Cristina Rusu

Podoplanin: a Prognostic Marker and a Potential Target for Therapy in Bladder Cancer

Abstract:

Invasive bladder cancer is a frequent neoplastic diseases, and despite progresses made in early diagnosis and surgical procedures, the outcome of patients is characterized by high rate of mortality. This is mainly due to the lack of response to chemotherapy and radiotherapy, and other new resources are limited. In the present work we analyzed 50 consecutive cases of invasive bladder cancer treated by open surgery. Specimens were processed using standard histological procedures, including establishment of the histological diagnosis and grading. Additional slides were stained for podoplanin expression, clone D2-40 to investigate the structure and number of lymphatic vessels. We found lymphatic vessels in both intra- and peritumor areas, showing significant differences in morphology and number. Lymphatic invasion by tumor cells was higher in peritumor than in intratumor vessels. Lymphatic microvessel density correlated with stage and grade of the tumor. Of interest is the expression of podoplanin by tumor cells of urothelial carcinoma in about 14% of the cases, with strong correlation with grading. Based on our results, expression of podoplanin in invasive bladder cancer might indicate three potential targets: lymphatics, myofibroblasts, and tumor cells in selected cases.
Keywords:
bladder cancer; immunohistochemistry; podoplanin; therapeutic target

Issue: 2019, Volume 70, Issue 12
Pages: 4393-4399
Publication date: 20/01/2020
https://doi.org/10.37358/RC.19.12.7764
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This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
ADELMANN, T., GAJE, N.P., RUSU, L.C., Podoplanin: a Prognostic Marker and a Potential Target for Therapy in Bladder Cancer, Rev. Chim., 70(12), 2019, 4393-4399.

Vancouver
Adelmann T, Gaje NP, Rusu LC. Podoplanin: a Prognostic Marker and a Potential Target for Therapy in Bladder Cancer. Rev. Chim.[internet]. 2019 Dec;70(12):4393-4399. Available from: https://doi.org/10.37358/RC.19.12.7764


APA 6th edition
Adelmann, T., Gaje, N.P. & Rusu, L.C. (2019). Podoplanin: a Prognostic Marker and a Potential Target for Therapy in Bladder Cancer. Revista de Chimie, 70(12), 4393-4399. https://doi.org/10.37358/RC.19.12.7764


Harvard
Adelmann, T., Gaje, N.P., Rusu, L.C. (2019). 'Podoplanin: a Prognostic Marker and a Potential Target for Therapy in Bladder Cancer', Revista de Chimie, 70(12), pp. 4393-4399. https://doi.org/10.37358/RC.19.12.7764


IEEE
T. Adelmann, N.P. Gaje, L.C. Rusu, "Podoplanin: a Prognostic Marker and a Potential Target for Therapy in Bladder Cancer". Revista de Chimie, vol. 70, no. 12, pp. 4393-4399, 2019. [online]. https://doi.org/10.37358/RC.19.12.7764


Text
Tiberiu Adelmann, Nela Pusa Gaje, Laura Cristina Rusu,
Podoplanin: a Prognostic Marker and a Potential Target for Therapy in Bladder Cancer,
Revista de Chimie,
Volume 70, Issue 12,
2019,
Pages 4393-4399,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.12.7764.
(https://revistadechimie.ro/Articles.asp?ID=7764)
Keywords: bladder cancer; immunohistochemistry; podoplanin; therapeutic target


RIS
TY - JOUR
T1 - Podoplanin: a Prognostic Marker and a Potential Target for Therapy in Bladder Cancer
A1 - Adelmann, Tiberiu
A2 - Gaje, Nela Pusa
A3 - Rusu, Laura Cristina
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 12
SP - 4393
EP - 4399
UR - https://doi.org/10.37358/RC.19.12.7764
KW - bladder cancer
KW - immunohistochemistry
KW - podoplanin
KW - therapeutic target
ER -


BibTex
@article{RevCh2019P4393,
author = {Adelmann Tiberiu and Gaje Nela Pusa and Rusu Laura Cristina},
title = {Podoplanin: a Prognostic Marker and a Potential Target for Therapy in Bladder Cancer},
journal = {Revista de Chimie},
volume = {70},
number = {12},
pages = {4393-4399},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.12.7764},
url = {https://revistadechimie.ro/Articles.asp?ID=7764}
}
 
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