Involvement of Markers D2-40, Cd10 and F-Actin in Squamous Cell Carcinoma Invasion of the Tongue

I. (Marasescu), Felicia Ileana Ciucă; Marasescu, Petre-Costin; Manolea, Maria Magdalena; Camen, Adrian; Munteanu, Cristina; Margaritescu, Claudiu; Popescu, Florin Dan; Mercut, Răzvan

Felicia Ileana Ciucă I. (Marasescu), Petre-Costin Marasescu, Maria Magdalena Manolea, Adrian Camen, Cristina Munteanu, Claudiu Margaritescu, Florin Dan Popescu, Răzvan Mercut

Involvement of Markers D2-40, Cd10 and F-Actin in Squamous Cell Carcinoma Invasion of the Tongue

Abstract:

In recent decades, an increase in the incidence of lingual squamous carcinoma, especially among young people, has been seen to be the most common form of oral cancer. In addition, this localization appears to be one of the most aggressive forms of oral squamous carcinoma, being highly locally invasive, with early metastasis, with a high rate of relapse and with a survival rate of 5 years being below 60%. To explain this phenotype, recent studies have shed light on the molecular mechanisms underlying lingual carcinogenesis, including loco-regional invasiveness with the study of markers involved in this process. From this perspective, our study proposed the investigation of the reactivity of markers D2-40, CD10 and F-actin in 57 squamous carcinomas of the tongue diagnosed in various stages, and we selected cases from the Archives of the Pathological Anatomy Laboratory of the County Emergency Hospital of Craiova (SCJUCraiova) during the years 2015-2017. The immunohistochemical technique used was that of detecting the LSAB enzyme, and the evaluation of tumor immunoreactivity was done using the semi-quantitative score described by Remmele and Stegner. Tumor reactivity was present mainly in moderately differentiated forms, usually periferic of the proliferation, in the invasion front, more intense in the acantholytic variant. On the opposite side there were cases of well differentiated squamous carcinoma, which obtained the lowest immunoreactivity scores. Reactivity was also present at the stromal level, especially in cases involving a desmoplastic reaction and inflammatory stroma cases, respectively. The pattern of predominant reactions at the periphery of the proliferation and the interface with the inflammatory or desmoplastic stroma proves the adoption by these neoplastic cells of a more aggressive phenotype with their successive involvement in local invasion and metastasis. Therefore, the markers used have prognostic value identifying the most aggressive forms of lingual squamous carcinoma thus allowing a therapeutic stratification of these patients who will benefit from a molecular targeting therapy.

Keywords:
tongue; squamous cell carcinoma; invasiveness; CD10; D2-40; F-actin

Issue: 2019, Volume 70, Issue 12

Pages: 4455-4465

Publication date: 2020/1/20

https://doi.org/10.37358/RC.19.12.7776

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
I. (MARASESCU), F.I.C., MARASESCU, P., MANOLEA, M.M., CAMEN, A., MUNTEANU, C., MARGARITESCU, C., POPESCU, F.D., MERCUT, R., Involvement of Markers D2-40, Cd10 and F-Actin in Squamous Cell Carcinoma Invasion of the Tongue, Rev. Chim., 70(12), 2019, 4455-4465.

Vancouver
I. (Marasescu) FIC, Marasescu P, Manolea MM, Camen A, Munteanu C, Margaritescu C, Popescu FD, Mercut R. Involvement of Markers D2-40, Cd10 and F-Actin in Squamous Cell Carcinoma Invasion of the Tongue. Rev. Chim.[internet]. 2019 Dec;70(12):4455-4465. Available from: https://doi.org/10.37358/RC.19.12.7776

APA 6th edition
I. (Marasescu), F.I.C., Marasescu, P., Manolea, M.M., Camen, A., Munteanu, C., Margaritescu, C., Popescu, F.D. & Mercut, R. (2019). Involvement of Markers D2-40, Cd10 and F-Actin in Squamous Cell Carcinoma Invasion of the Tongue. Revista de Chimie, 70(12), 4455-4465. https://doi.org/10.37358/RC.19.12.7776

Harvard
I. (Marasescu), F.I.C., Marasescu, P., Manolea, M.M., Camen, A., Munteanu, C., Margaritescu, C., Popescu, F.D., Mercut, R. (2019). 'Involvement of Markers D2-40, Cd10 and F-Actin in Squamous Cell Carcinoma Invasion of the Tongue', Revista de Chimie, 70(12), pp. 4455-4465. https://doi.org/10.37358/RC.19.12.7776

IEEE
F.I.C. I.(Marasescu), P. Marasescu, M.M. Manolea, A. Camen, C. Munteanu, C. Margaritescu, F.D. Popescu, R. Mercut, "Involvement of Markers D2-40, Cd10 and F-Actin in Squamous Cell Carcinoma Invasion of the Tongue". Revista de Chimie, vol. 70, no. 12, pp. 4455-4465, 2019. [online]. https://doi.org/10.37358/RC.19.12.7776

Text
Felicia Ileana Ciucă I.(Marasescu), Petre-Costin Marasescu, Maria Magdalena Manolea, Adrian Camen, Cristina Munteanu, Claudiu Margaritescu, Florin Dan Popescu, Răzvan Mercut,
Involvement of Markers D2-40, Cd10 and F-Actin in Squamous Cell Carcinoma Invasion of the Tongue,
Revista de Chimie,
Volume 70, Issue 12,
2019,
Pages 4455-4465,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.12.7776.
(https://revistadechimie.ro/Articles.asp?ID=7776)
Keywords: tongue; squamous cell carcinoma; invasiveness; CD10; D2-40; F-actin

RIS
TY - JOUR
T1 - Involvement of Markers D2-40, Cd10 and F-Actin in Squamous Cell Carcinoma Invasion of the Tongue
A1 - I. (Marasescu), Felicia Ileana Ciucă
A2 - Marasescu, Petre-Costin
A3 - Manolea, Maria Magdalena
A4 - Camen, Adrian
A5 - Munteanu, Cristina
A6 - Margaritescu, Claudiu
A7 - Popescu, Florin Dan
A8 - Mercut, Răzvan
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 12
SP - 4455
EP - 4465
UR - https://doi.org/10.37358/RC.19.12.7776
KW - tongue
KW - squamous cell carcinoma
KW - invasiveness
KW - CD10
KW - D2-40
KW - F-actin
ER -

BibTex
@article{RevCh2019P4455,
author = {I. (Marasescu) Felicia Ileana Ciucă and Marasescu Petre-Costin and Manolea Maria Magdalena and Camen Adrian and Munteanu Cristina and Margaritescu Claudiu and Popescu Florin Dan and Mercut Răzvan},
title = {Involvement of Markers D2-40, Cd10 and F-Actin in Squamous Cell Carcinoma Invasion of the Tongue},
journal = {Revista de Chimie},
volume = {70},
number = {12},
pages = {4455-4465},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.12.7776},
url = {https://revistadechimie.ro/Articles.asp?ID=7776}
}

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