Comparative Evaluation of the Bladder Tumor-Associated <br>Antigen, Urinary Bladder Cancer Antigen, Tissue Polypeptide Specific Antigen and Voided Urine Cytology in Early Detection <br>of Primary Bladder Tumors

Stanciu, Adina Elena; Serdarevic, Nafija; Stanciu, Marcel Marian; Mazilu, Laura; Bratu, Ovidiu; Gherghe, Mirela; Voinea, Silviu Cristian; Gheorghe, Dan Cristian

Adina Elena Stanciu, Nafija Serdarevic, Marcel Marian Stanciu, Laura Mazilu, Ovidiu Bratu, Mirela Gherghe, Silviu Cristian Voinea, Dan Cristian Gheorghe

Comparative Evaluation of the Bladder Tumor-Associated
Antigen, Urinary Bladder Cancer Antigen, Tissue Polypeptide Specific Antigen and Voided Urine Cytology in Early Detection
of Primary Bladder Tumors

Abstract:

Although a large number of biomarkers for primary assessment of non-muscle-invasive bladder cancer (NMIBC) have been explored, their real diagnostic performance is not well known. This study aimed to conduct a direct comparison of three biomarkers [bladder tumor-associated antigen (BTA), urinary bladder cancer antigen (UBC) and tissue polypeptide specific antigen (TPS)] with some unique characteristics for detection of NMIBC and to compare their diagnostic accuracy to that of routine urine cytology. Our results indicated that the overall clinical sensitivity of BTA was the highest of all assays (76.92%), whereas that of cytology was the smallest one (12.50%). On the other hand, BTA and cytology had the highest specificities (89.79% vs. 96.87%) with no significant differences between them. A multi-biomarker panel including BTA, UBC, and TPS with an overall clinical specificity of 100% better assess the primary NMIBC as compared to approaches entailing just one or two of these biomarkers or routine urine cytology.

Keywords:
BTA; UBC; TPS; urinary cytology; bladder cancer

Issue: 2019, Volume 70, Issue 12

Pages: 4514-4518

Publication date: 2020/1/20

https://doi.org/10.37358/RC.19.12.7786

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
STANCIU, A.E., SERDAREVIC, N., STANCIU, M.M., MAZILU, L., BRATU, O., GHERGHE, M., VOINEA, S.C., GHEORGHE, D.C., Comparative Evaluation of the Bladder Tumor-Associated
Antigen, Urinary Bladder Cancer Antigen, Tissue Polypeptide Specific Antigen and Voided Urine Cytology in Early Detection
of Primary Bladder Tumors, Rev. Chim., 70(12), 2019, 4514-4518.

Vancouver
Stanciu AE, Serdarevic N, Stanciu MM, Mazilu L, Bratu O, Gherghe M, Voinea SC, Gheorghe DC. Comparative Evaluation of the Bladder Tumor-Associated
Antigen, Urinary Bladder Cancer Antigen, Tissue Polypeptide Specific Antigen and Voided Urine Cytology in Early Detection
of Primary Bladder Tumors. Rev. Chim.[internet]. 2019 Dec;70(12):4514-4518. Available from: https://doi.org/10.37358/RC.19.12.7786

APA 6th edition
Stanciu, A.E., Serdarevic, N., Stanciu, M.M., Mazilu, L., Bratu, O., Gherghe, M., Voinea, S.C. & Gheorghe, D.C. (2019). Comparative Evaluation of the Bladder Tumor-Associated
Antigen, Urinary Bladder Cancer Antigen, Tissue Polypeptide Specific Antigen and Voided Urine Cytology in Early Detection
of Primary Bladder Tumors. Revista de Chimie, 70(12), 4514-4518. https://doi.org/10.37358/RC.19.12.7786

Harvard
Stanciu, A.E., Serdarevic, N., Stanciu, M.M., Mazilu, L., Bratu, O., Gherghe, M., Voinea, S.C., Gheorghe, D.C. (2019). 'Comparative Evaluation of the Bladder Tumor-Associated
Antigen, Urinary Bladder Cancer Antigen, Tissue Polypeptide Specific Antigen and Voided Urine Cytology in Early Detection
of Primary Bladder Tumors', Revista de Chimie, 70(12), pp. 4514-4518. https://doi.org/10.37358/RC.19.12.7786

IEEE
A.E. Stanciu, N. Serdarevic, M.M. Stanciu, L. Mazilu, O. Bratu, M. Gherghe, S.C. Voinea, D.C. Gheorghe, "Comparative Evaluation of the Bladder Tumor-Associated
Antigen, Urinary Bladder Cancer Antigen, Tissue Polypeptide Specific Antigen and Voided Urine Cytology in Early Detection
of Primary Bladder Tumors". Revista de Chimie, vol. 70, no. 12, pp. 4514-4518, 2019. [online]. https://doi.org/10.37358/RC.19.12.7786

Text
Adina Elena Stanciu, Nafija Serdarevic, Marcel Marian Stanciu, Laura Mazilu, Ovidiu Bratu, Mirela Gherghe, Silviu Cristian Voinea, Dan Cristian Gheorghe,
Comparative Evaluation of the Bladder Tumor-Associated
Antigen, Urinary Bladder Cancer Antigen, Tissue Polypeptide Specific Antigen and Voided Urine Cytology in Early Detection
of Primary Bladder Tumors,
Revista de Chimie,
Volume 70, Issue 12,
2019,
Pages 4514-4518,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.12.7786.
(https://revistadechimie.ro/Articles.asp?ID=7786)
Keywords: BTA; UBC; TPS; urinary cytology; bladder cancer

RIS
TY - JOUR
T1 - Comparative Evaluation of the Bladder Tumor-Associated
Antigen, Urinary Bladder Cancer Antigen, Tissue Polypeptide Specific Antigen and Voided Urine Cytology in Early Detection
of Primary Bladder Tumors
A1 - Stanciu, Adina Elena
A2 - Serdarevic, Nafija
A3 - Stanciu, Marcel Marian
A4 - Mazilu, Laura
A5 - Bratu, Ovidiu
A6 - Gherghe, Mirela
A7 - Voinea, Silviu Cristian
A8 - Gheorghe, Dan Cristian
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 12
SP - 4514
EP - 4518
UR - https://doi.org/10.37358/RC.19.12.7786
KW - BTA
KW - UBC
KW - TPS
KW - urinary cytology
KW - bladder cancer
ER -

BibTex
@article{RevCh2019P4514,
author = {Stanciu Adina Elena and Serdarevic Nafija and Stanciu Marcel Marian and Mazilu Laura and Bratu Ovidiu and Gherghe Mirela and Voinea Silviu Cristian and Gheorghe Dan Cristian},
title = {Comparative Evaluation of the Bladder Tumor-Associated
Antigen, Urinary Bladder Cancer Antigen, Tissue Polypeptide Specific Antigen and Voided Urine Cytology in Early Detection
of Primary Bladder Tumors},
journal = {Revista de Chimie},
volume = {70},
number = {12},
pages = {4514-4518},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.12.7786},
url = {https://revistadechimie.ro/Articles.asp?ID=7786}
}

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