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Revista de Chimie (Rev. Chim.), Year 2019, Volume 70, Issue 12, 4532-4536

https://doi.org/10.37358/RC.19.12.7789

Răzvan Popovici, Alexandru Cărăuleanu, Tudor Ioan Lazar, Antoneta Dacia Petroaie, Alexandra Pangal, Mihaela Grigore, Irina Esanu

The Overexpression of Folate Receptors in Gynecologic Oncology - a Diagnostic and Therapeutic Approach

Abstract:

Since the discovery of the overexpression of alpha folate receptors (α-FR) in different types of epithelial origin cancers, the arising implications in diagnosis, prognosis and therapy have been thoroughly studied. The α-FR is a glycosylphosphatidylinositol-anchored protein with high affinity for 5-methyltetrahydrofolate, the predominant plasma folate. The expression of FRα in healthy cells is found to be only on the apical surface, but the expression in numerous carcinomas of epithelial origin is 100-300 times higher than on healthy cells and it is in the order of 1-10 million receptor copies per cell. Due to the increased expression of α-FR in epithelial tumor cells, it has been emphasized that this receptor could represent a useful target for the development of new and selective anticancer drugs. For targeted delivery to FR expressing cells, it is involved the covalent linkage of folate to a variety of molecules, including chemotherapy or imaging agents. Exploiting the overexpression of α-FR in cervical dysplasia and cervical cancer, a new, cost effective and high sensitivity screening test has been developed.
Keywords:
folate receptor; gynecologic oncology; folate receptor-mediated staining procedures; cervical cancer screening.

Issue: 2019, Volume 70, Issue 12
Pages: 4532-4536
Publication date: 20/01/2020
https://doi.org/10.37358/RC.19.12.7789
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
POPOVICI, R., CĂRĂULEANU, A., LAZAR, T.I., PETROAIE, A.D., PANGAL, A., GRIGORE, M., ESANU, I., The Overexpression of Folate Receptors in Gynecologic Oncology - a Diagnostic and Therapeutic Approach, Rev. Chim., 70(12), 2019, 4532-4536.

Vancouver
Popovici R, Cărăuleanu A, Lazar TI, Petroaie AD, Pangal A, Grigore M, Esanu I. The Overexpression of Folate Receptors in Gynecologic Oncology - a Diagnostic and Therapeutic Approach. Rev. Chim.[internet]. 2019 Dec;70(12):4532-4536. Available from: https://doi.org/10.37358/RC.19.12.7789


APA 6th edition
Popovici, R., Cărăuleanu, A., Lazar, T.I., Petroaie, A.D., Pangal, A., Grigore, M. & Esanu, I. (2019). The Overexpression of Folate Receptors in Gynecologic Oncology - a Diagnostic and Therapeutic Approach. Revista de Chimie, 70(12), 4532-4536. https://doi.org/10.37358/RC.19.12.7789


Harvard
Popovici, R., Cărăuleanu, A., Lazar, T.I., Petroaie, A.D., Pangal, A., Grigore, M., Esanu, I. (2019). 'The Overexpression of Folate Receptors in Gynecologic Oncology - a Diagnostic and Therapeutic Approach', Revista de Chimie, 70(12), pp. 4532-4536. https://doi.org/10.37358/RC.19.12.7789


IEEE
R. Popovici, A. Cărăuleanu, T.I. Lazar, A.D. Petroaie, A. Pangal, M. Grigore, I. Esanu, "The Overexpression of Folate Receptors in Gynecologic Oncology - a Diagnostic and Therapeutic Approach". Revista de Chimie, vol. 70, no. 12, pp. 4532-4536, 2019. [online]. https://doi.org/10.37358/RC.19.12.7789


Text
Răzvan Popovici, Alexandru Cărăuleanu, Tudor Ioan Lazar, Antoneta Dacia Petroaie, Alexandra Pangal, Mihaela Grigore, Irina Esanu,
The Overexpression of Folate Receptors in Gynecologic Oncology - a Diagnostic and Therapeutic Approach,
Revista de Chimie,
Volume 70, Issue 12,
2019,
Pages 4532-4536,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.12.7789.
(https://revistadechimie.ro/Articles.asp?ID=7789)
Keywords: folate receptor; gynecologic oncology; folate receptor-mediated staining procedures; cervical cancer screening.


RIS
TY - JOUR
T1 - The Overexpression of Folate Receptors in Gynecologic Oncology - a Diagnostic and Therapeutic Approach
A1 - Popovici, Răzvan
A2 - Cărăuleanu, Alexandru
A3 - Lazar, Tudor Ioan
A4 - Petroaie, Antoneta Dacia
A5 - Pangal, Alexandra
A6 - Grigore, Mihaela
A7 - Esanu, Irina
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 12
SP - 4532
EP - 4536
UR - https://doi.org/10.37358/RC.19.12.7789
KW - folate receptor
KW - gynecologic oncology
KW - folate receptor-mediated staining procedures
KW - cervical cancer screening.
ER -


BibTex
@article{RevCh2019P4532,
author = {Popovici Răzvan and Cărăuleanu Alexandru and Lazar Tudor Ioan and Petroaie Antoneta Dacia and Pangal Alexandra and Grigore Mihaela and Esanu Irina},
title = {The Overexpression of Folate Receptors in Gynecologic Oncology - a Diagnostic and Therapeutic Approach},
journal = {Revista de Chimie},
volume = {70},
number = {12},
pages = {4532-4536},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.12.7789},
url = {https://revistadechimie.ro/Articles.asp?ID=7789}
}
 
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