The Impact of Valve Calcifications Upon the Haemodynamic Severity of Aortic Stenosis

Furnica, Cristina; Perianu, Lacramioara; Oancea (Radulescu), Andra; Schaas, Carmina Mihaela; Tinica, Grigore

Cristina Furnica, Lacramioara Perianu, Andra Oancea (Radulescu), Carmina Mihaela Schaas, Grigore Tinica

The Impact of Valve Calcifications Upon the Haemodynamic Severity of Aortic Stenosis

Abstract:

The calcific aortic stenosis (AS) is characterized by progressive obstruction of the aortic valve opening and results from the action of several active cellular processes that lead to valve remodelling, promote fibrosis and valvular calcification. The purpose of the study is to assess the relationship between the severity of aortic valve calcifications quantified by the Agatston score density and the hemodynamic impact of aortic stenosis determined through Doppler echocardiography. The authors performed a retrospective analysis of 70 cases that benefited of transcatheter aortic valve implantation between January 2015-October 2019. All patients underwent cardiac computed tomography and comprehensive Doppler echocardiography prior to the procedure. The degree of calcification of aortic leaflets was quantified on non-contrast CT examinations in all cases using the Agatston score and its relationship with dynamic echocardiographic parameters was evaluated using specific statistical tests. Aortic valve Agatston score density showed a significant correlation with mean transvalvular gradient (R = 0,62, p[0.0001) same as age (R = 0.51, p = 0.036). These parameters together with sex, body mass index, body surface area, the status of arterial hypertension, dyslipidaemia, smoking, bicuspid aortic valve, history of coronary artery disease were introduced into a multivariate regression to identify independent predictors of the mean transvalvular gradient. Age (ß= -0.25, p = 0.003), aortic valve Agatston score density (ß =-0.63, p[0.001) and bicuspid aortic valve (ß = -0.32, p = 0,003) proved to be the only independent predictors of the haemodynamic severity of aortic stenosis. In conclusion, the degree of aortic valve calcifications is a strong indicator for the haemodynamic impact of AS. Cardiac computed tomography is a non-invasive and accurate method of evaluating aortic valve calcifications and could be used to grade the severity of AS in cases where echocardiographic findings are discordant.

Keywords:
transcatheter aortic valve implantation; leaflet calcification; hydroxyapatite; Agatston score; transvalvular gradient

Issue: 2019, Volume 70, Issue 12

Pages: 4545-4549

Publication date: 2020/1/20

https://doi.org/10.37358/RC.19.12.7791

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
FURNICA, C., PERIANU, L., OANCEA (RADULESCU), A., SCHAAS, C.M., TINICA, G., The Impact of Valve Calcifications Upon the Haemodynamic Severity of Aortic Stenosis, Rev. Chim., 70(12), 2019, 4545-4549.

Vancouver
Furnica C, Perianu L, Oancea (Radulescu) A, Schaas CM, Tinica G. The Impact of Valve Calcifications Upon the Haemodynamic Severity of Aortic Stenosis. Rev. Chim.[internet]. 2019 Dec;70(12):4545-4549. Available from: https://doi.org/10.37358/RC.19.12.7791

APA 6th edition
Furnica, C., Perianu, L., Oancea (Radulescu), A., Schaas, C.M. & Tinica, G. (2019). The Impact of Valve Calcifications Upon the Haemodynamic Severity of Aortic Stenosis. Revista de Chimie, 70(12), 4545-4549. https://doi.org/10.37358/RC.19.12.7791

Harvard
Furnica, C., Perianu, L., Oancea (Radulescu), A., Schaas, C.M., Tinica, G. (2019). 'The Impact of Valve Calcifications Upon the Haemodynamic Severity of Aortic Stenosis', Revista de Chimie, 70(12), pp. 4545-4549. https://doi.org/10.37358/RC.19.12.7791

IEEE
C. Furnica, L. Perianu, A. Oancea(Radulescu), C.M. Schaas, G. Tinica, "The Impact of Valve Calcifications Upon the Haemodynamic Severity of Aortic Stenosis". Revista de Chimie, vol. 70, no. 12, pp. 4545-4549, 2019. [online]. https://doi.org/10.37358/RC.19.12.7791

Text
Cristina Furnica, Lacramioara Perianu, Andra Oancea(Radulescu), Carmina Mihaela Schaas, Grigore Tinica,
The Impact of Valve Calcifications Upon the Haemodynamic Severity of Aortic Stenosis,
Revista de Chimie,
Volume 70, Issue 12,
2019,
Pages 4545-4549,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.12.7791.
(https://revistadechimie.ro/Articles.asp?ID=7791)
Keywords: transcatheter aortic valve implantation; leaflet calcification; hydroxyapatite; Agatston score; transvalvular gradient

RIS
TY - JOUR
T1 - The Impact of Valve Calcifications Upon the Haemodynamic Severity of Aortic Stenosis
A1 - Furnica, Cristina
A2 - Perianu, Lacramioara
A3 - Oancea (Radulescu), Andra
A4 - Schaas, Carmina Mihaela
A5 - Tinica, Grigore
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 12
SP - 4545
EP - 4549
UR - https://doi.org/10.37358/RC.19.12.7791
KW - transcatheter aortic valve implantation
KW - leaflet calcification
KW - hydroxyapatite
KW - Agatston score
KW - transvalvular gradient
ER -

BibTex
@article{RevCh2019P4545,
author = {Furnica Cristina and Perianu Lacramioara and Oancea (Radulescu) Andra and Schaas Carmina Mihaela and Tinica Grigore},
title = {The Impact of Valve Calcifications Upon the Haemodynamic Severity of Aortic Stenosis},
journal = {Revista de Chimie},
volume = {70},
number = {12},
pages = {4545-4549},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.12.7791},
url = {https://revistadechimie.ro/Articles.asp?ID=7791}
}

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