The Diagnostic Value of Hepatocyte Paraffin Antibody 1 in Differentiating  Hepatocellular Carcinoma from non-hepatic Tumors

Goldis, Adrian; Basa, Norina; Lazar, Daniela; Goldis, Ramona; Jurescu, Aura; Dobrescu, Amadeus; Barna, Robert; Cornianu, Marioara

Adrian Goldis, Norina Basa, Daniela Lazar, Ramona Goldis, Aura Jurescu, Amadeus Dobrescu, Robert Barna, Marioara Cornianu

The Diagnostic Value of Hepatocyte Paraffin Antibody 1 in Differentiating Hepatocellular Carcinoma from non-hepatic Tumors

Abstract:

The paper presents approaches the topic of hepatocellular carcinoma (HCC) differential diagnosis with various other malignant tumors, as such differentiation can be in many cases performed only based on a thorough immunohistochemical marker designed for hepatocellular differentiation. Hepatocyte paraffin-1(Hep Par-1), is a specific antibody for hepatocellular tissue that is represented within both healthy and malignant hepatic cells. The paper evaluated the expression of Hep Par-1 on paraffin tissue acquisitions of selected cases of resecable hepatocellular carcinoma referred for curative surgery (20 cases). For the experimental part, mouse anti-human hepatocyte monoclonal antibodies, Hepatocyte Ab1,and diluted clones of OCH1E5 with the EnVision technique have been used. The results were suggestive for positive expression of Hep Par-1 in 15 of the 20 cases of HCC (75%), with various degrees secondary to the differentiation degree (which was positive in all 15 G1-G2 HCCs and negative in 5 G3-G4 HCCs); on the other hand, the study showed a non-homogenous and focal Hep Par-1 distribution malignant tissue engaging a uniform staining of the non-tumorous liver tissue surrounding the lesion. The study did not show Hep Par-1 immunostaining in non-hepatocytic tumors, excepting some focal expression on a gastric adenocarcinoma with clear patchy expression. Our research confirms that Hep Par-1 can be considered a valuable marker in the diagnosis of HCC, although not totally specific; thus, it should be used in a conjugated manner with various other markers useful in hepatocellular differentiation.

Keywords:
hepatocellular carcinoma; metastatic carcinoma; Hep Par-1; differential diagnosis of HCC

Issue: 2019, Volume 70, Issue 12

Pages: 4550-4556

Publication date: 2020/1/20

https://doi.org/10.37358/RC.19.12.7792

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
GOLDIS, A., BASA, N., LAZAR, D., GOLDIS, R., JURESCU, A., DOBRESCU, A., BARNA, R., CORNIANU, M., The Diagnostic Value of Hepatocyte Paraffin Antibody 1 in Differentiating Hepatocellular Carcinoma from non-hepatic Tumors, Rev. Chim., 70(12), 2019, 4550-4556.

Vancouver
Goldis A, Basa N, Lazar D, Goldis R, Jurescu A, Dobrescu A, Barna R, Cornianu M. The Diagnostic Value of Hepatocyte Paraffin Antibody 1 in Differentiating Hepatocellular Carcinoma from non-hepatic Tumors. Rev. Chim.[internet]. 2019 Dec;70(12):4550-4556. Available from: https://doi.org/10.37358/RC.19.12.7792

APA 6th edition
Goldis, A., Basa, N., Lazar, D., Goldis, R., Jurescu, A., Dobrescu, A., Barna, R. & Cornianu, M. (2019). The Diagnostic Value of Hepatocyte Paraffin Antibody 1 in Differentiating Hepatocellular Carcinoma from non-hepatic Tumors. Revista de Chimie, 70(12), 4550-4556. https://doi.org/10.37358/RC.19.12.7792

Harvard
Goldis, A., Basa, N., Lazar, D., Goldis, R., Jurescu, A., Dobrescu, A., Barna, R., Cornianu, M. (2019). 'The Diagnostic Value of Hepatocyte Paraffin Antibody 1 in Differentiating Hepatocellular Carcinoma from non-hepatic Tumors', Revista de Chimie, 70(12), pp. 4550-4556. https://doi.org/10.37358/RC.19.12.7792

IEEE
A. Goldis, N. Basa, D. Lazar, R. Goldis, A. Jurescu, A. Dobrescu, R. Barna, M. Cornianu, "The Diagnostic Value of Hepatocyte Paraffin Antibody 1 in Differentiating Hepatocellular Carcinoma from non-hepatic Tumors". Revista de Chimie, vol. 70, no. 12, pp. 4550-4556, 2019. [online]. https://doi.org/10.37358/RC.19.12.7792

Text
Adrian Goldis, Norina Basa, Daniela Lazar, Ramona Goldis, Aura Jurescu, Amadeus Dobrescu, Robert Barna, Marioara Cornianu,
The Diagnostic Value of Hepatocyte Paraffin Antibody 1 in Differentiating Hepatocellular Carcinoma from non-hepatic Tumors,
Revista de Chimie,
Volume 70, Issue 12,
2019,
Pages 4550-4556,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.12.7792.
(https://revistadechimie.ro/Articles.asp?ID=7792)
Keywords: hepatocellular carcinoma; metastatic carcinoma; Hep Par-1; differential diagnosis of HCC

RIS
TY - JOUR
T1 - The Diagnostic Value of Hepatocyte Paraffin Antibody 1 in Differentiating Hepatocellular Carcinoma from non-hepatic Tumors
A1 - Goldis, Adrian
A2 - Basa, Norina
A3 - Lazar, Daniela
A4 - Goldis, Ramona
A5 - Jurescu, Aura
A6 - Dobrescu, Amadeus
A7 - Barna, Robert
A8 - Cornianu, Marioara
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 12
SP - 4550
EP - 4556
UR - https://doi.org/10.37358/RC.19.12.7792
KW - hepatocellular carcinoma
KW - metastatic carcinoma
KW - Hep Par-1
KW - differential diagnosis of HCC
ER -

BibTex
@article{RevCh2019P4550,
author = {Goldis Adrian and Basa Norina and Lazar Daniela and Goldis Ramona and Jurescu Aura and Dobrescu Amadeus and Barna Robert and Cornianu Marioara},
title = {The Diagnostic Value of Hepatocyte Paraffin Antibody 1 in Differentiating Hepatocellular Carcinoma from non-hepatic Tumors},
journal = {Revista de Chimie},
volume = {70},
number = {12},
pages = {4550-4556},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.12.7792},
url = {https://revistadechimie.ro/Articles.asp?ID=7792}
}

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