Copper-Modified Boron-Doped Diamond (Cu/Bdd) Electrode for the Electrochemical Detection of Paclitaxel and Oxaliplatin in Aqueous Solutions

Negrea, Sorina-Claudia; Diaconu, Lidia Ani; Nicorescu, Valeria; Baciu, Anamaria; Pop, Aniela; Manea, Florica

Sorina-Claudia Negrea, Lidia Ani Diaconu, Valeria Nicorescu, Anamaria Baciu, Aniela Pop, Florica Manea

Copper-Modified Boron-Doped Diamond (Cu/Bdd) Electrode for the Electrochemical Detection of Paclitaxel and Oxaliplatin in Aqueous Solutions

Abstract:

The aim of this study was to obtain a simple and fast modified electrode for the detection of paclitaxel (PCX) and oxaliplatin (OXA) in aqueous solution. PCX and OXA are some of the most used cytostatic drugs suitable to treat various types of cancer, e.g., ovarian, breast, lung, cervical, pancreatic, Kaposi’s sarcoma. The development of an easy method for its determination is required for both the dosage in cancer therapy and due its potential presence in environment and especially, in water samples. Boron doped diamond (BDD) electrode was electrochemically modified with copper (Cu) by chronoamperometry (CA) operated under optimized conditions of -0.75 V/SCE potential level for 120 minutes. Copper-modified boron-doped diamond (Cu/BDD) exhibited the electrocatalytic effect towards the paclitaxel and oxaliplatin oxidation, allowing their detection in 0.1 M NaOH supporting electrolyte. The limiting anodic current was noticed at the potential value of +0.75 V/SCE that increased linearly with PCX concentration, and at the potential value of + 0.6V/SCE for the oxaliplatin. Some mechanical aspects related to the PCX oxidation at Cu/BDD electrode in 0.1 M NaOH supporting electrolyte were determined using cyclic voltammetry (CV) recorded at various scan rates. CV was based on compounds detection and achieved the sensitivity of 0.65 μA/µM for oxaliplatin and respective, 5.47 μA/µM for paclitaxel.

Keywords:
copper; electrochemical detection; modified boron-doped diamond electrode paclitaxel; oxaliplatin

Issue: 2019, Volume 70, Issue 12

Pages: 4595-4600

Publication date: 2020/1/20

https://doi.org/10.37358/RC.19.12.7799

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Citation Styles

Cite this article as:
NEGREA, S., DIACONU, L.A., NICORESCU, V., BACIU, A., POP, A., MANEA, F., Copper-Modified Boron-Doped Diamond (Cu/Bdd) Electrode for the Electrochemical Detection of Paclitaxel and Oxaliplatin in Aqueous Solutions, Rev. Chim., 70(12), 2019, 4595-4600.

Vancouver
Negrea S, Diaconu LA, Nicorescu V, Baciu A, Pop A, Manea F. Copper-Modified Boron-Doped Diamond (Cu/Bdd) Electrode for the Electrochemical Detection of Paclitaxel and Oxaliplatin in Aqueous Solutions. Rev. Chim.[internet]. 2019 Dec;70(12):4595-4600. Available from: https://doi.org/10.37358/RC.19.12.7799

APA 6th edition
Negrea, S., Diaconu, L.A., Nicorescu, V., Baciu, A., Pop, A. & Manea, F. (2019). Copper-Modified Boron-Doped Diamond (Cu/Bdd) Electrode for the Electrochemical Detection of Paclitaxel and Oxaliplatin in Aqueous Solutions. Revista de Chimie, 70(12), 4595-4600. https://doi.org/10.37358/RC.19.12.7799

Harvard
Negrea, S., Diaconu, L.A., Nicorescu, V., Baciu, A., Pop, A., Manea, F. (2019). 'Copper-Modified Boron-Doped Diamond (Cu/Bdd) Electrode for the Electrochemical Detection of Paclitaxel and Oxaliplatin in Aqueous Solutions', Revista de Chimie, 70(12), pp. 4595-4600. https://doi.org/10.37358/RC.19.12.7799

IEEE
S. Negrea, L.A. Diaconu, V. Nicorescu, A. Baciu, A. Pop, F. Manea, "Copper-Modified Boron-Doped Diamond (Cu/Bdd) Electrode for the Electrochemical Detection of Paclitaxel and Oxaliplatin in Aqueous Solutions". Revista de Chimie, vol. 70, no. 12, pp. 4595-4600, 2019. [online]. https://doi.org/10.37358/RC.19.12.7799

Text
Sorina-Claudia Negrea, Lidia Ani Diaconu, Valeria Nicorescu, Anamaria Baciu, Aniela Pop, Florica Manea,
Copper-Modified Boron-Doped Diamond (Cu/Bdd) Electrode for the Electrochemical Detection of Paclitaxel and Oxaliplatin in Aqueous Solutions,
Revista de Chimie,
Volume 70, Issue 12,
2019,
Pages 4595-4600,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.12.7799.
(https://revistadechimie.ro/Articles.asp?ID=7799)
Keywords: copper; electrochemical detection; modified boron-doped diamond electrode paclitaxel; oxaliplatin

RIS
TY - JOUR
T1 - Copper-Modified Boron-Doped Diamond (Cu/Bdd) Electrode for the Electrochemical Detection of Paclitaxel and Oxaliplatin in Aqueous Solutions
A1 - Negrea, Sorina-Claudia
A2 - Diaconu, Lidia Ani
A3 - Nicorescu, Valeria
A4 - Baciu, Anamaria
A5 - Pop, Aniela
A6 - Manea, Florica
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 12
SP - 4595
EP - 4600
UR - https://doi.org/10.37358/RC.19.12.7799
KW - copper
KW - electrochemical detection
KW - modified boron-doped diamond electrode paclitaxel
KW - oxaliplatin
ER -

BibTex
@article{RevCh2019P4595,
author = {Negrea Sorina-Claudia and Diaconu Lidia Ani and Nicorescu Valeria and Baciu Anamaria and Pop Aniela and Manea Florica},
title = {Copper-Modified Boron-Doped Diamond (Cu/Bdd) Electrode for the Electrochemical Detection of Paclitaxel and Oxaliplatin in Aqueous Solutions},
journal = {Revista de Chimie},
volume = {70},
number = {12},
pages = {4595-4600},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.12.7799},
url = {https://revistadechimie.ro/Articles.asp?ID=7799}
}

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