SPE-LC/MS/MS Method for Detection of Antidiabetic Contaminants in Municipal and Rural Wastewater

Iancu, Vasile-Ion; Radu, Gabriel-Lucian; Scutariu, Roxana; Chiriac, Laura-Florentina; Galaon, Toma; Petre, Jana

Vasile-Ion Iancu, Gabriel-Lucian Radu, Roxana Scutariu, Laura-Florentina Chiriac, Toma Galaon, Jana Petre

SPE-LC/MS/MS Method for Detection of Antidiabetic Contaminants in Municipal and Rural Wastewater

Abstract:

Antidiabetic drugs are among the most prescribed and consumed pharmaceuticals worldwide. Their occurrence in environment was little investigated due of lack of analytcial methods for their detection in waters. In this work has been developed a selective SPE-UHPLC/MS/MS method for isolation, identification and quantification of some antidiabetic compounds. The 3 selected analytes (glyburide, glimepiride and repaglinide) were separated on Eclipse C18 LC column at 300C using isocrat elution with mobile phase of acetonitrile: 0.04% acetic acid (60/40, v/v %). The optimal flow rate was 0.2 mL/min and the injected volum was 10 µL. The contaminants were detected in negative electropray ionization mode (ESI-) by Multiple Reaction Monitoring (MRM). Collision energy, fragmentor voltages were optimized to obtain high sensitivity. Optimization of SPE-LC-MS/MS parameters gave low quantification limit values between 0.27 and 11.1 ng/L. The organic pollutants were isolated from waste water samples on Strata C18 cartridges. The linear regressions were drawn in the interval of 1-100ng/L with good determination coefficients. Spike recovery rates were between 74.5 and 88.2% for waste water, with satisfactory precisions (RSD[15). the method was applied to analyze real influent and effluent of wastewater treatment plant (WWTP) samples.

Keywords:
antidiabetic contaminants; liquid chromatography-mass spectrometry; wastewater

Issue: 2019, Volume 70, Issue 12

Pages: 4607-4613

Publication date: 2020/1/20

https://doi.org/10.37358/RC.19.12.7801

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
IANCU, V., RADU, G., SCUTARIU, R., CHIRIAC, L., GALAON, T., PETRE, J., SPE-LC/MS/MS Method for Detection of Antidiabetic Contaminants in Municipal and Rural Wastewater, Rev. Chim., 70(12), 2019, 4607-4613.

Vancouver
Iancu V, Radu G, Scutariu R, Chiriac L, Galaon T, Petre J. SPE-LC/MS/MS Method for Detection of Antidiabetic Contaminants in Municipal and Rural Wastewater. Rev. Chim.[internet]. 2019 Dec;70(12):4607-4613. Available from: https://doi.org/10.37358/RC.19.12.7801

APA 6th edition
Iancu, V., Radu, G., Scutariu, R., Chiriac, L., Galaon, T. & Petre, J. (2019). SPE-LC/MS/MS Method for Detection of Antidiabetic Contaminants in Municipal and Rural Wastewater. Revista de Chimie, 70(12), 4607-4613. https://doi.org/10.37358/RC.19.12.7801

Harvard
Iancu, V., Radu, G., Scutariu, R., Chiriac, L., Galaon, T., Petre, J. (2019). 'SPE-LC/MS/MS Method for Detection of Antidiabetic Contaminants in Municipal and Rural Wastewater', Revista de Chimie, 70(12), pp. 4607-4613. https://doi.org/10.37358/RC.19.12.7801

IEEE
V. Iancu, G. Radu, R. Scutariu, L. Chiriac, T. Galaon, J. Petre, "SPE-LC/MS/MS Method for Detection of Antidiabetic Contaminants in Municipal and Rural Wastewater". Revista de Chimie, vol. 70, no. 12, pp. 4607-4613, 2019. [online]. https://doi.org/10.37358/RC.19.12.7801

Text
Vasile-Ion Iancu, Gabriel-Lucian Radu, Roxana Scutariu, Laura-Florentina Chiriac, Toma Galaon, Jana Petre,
SPE-LC/MS/MS Method for Detection of Antidiabetic Contaminants in Municipal and Rural Wastewater,
Revista de Chimie,
Volume 70, Issue 12,
2019,
Pages 4607-4613,
ISSN 2668-8212,
https://doi.org/10.37358/RC.19.12.7801.
(https://revistadechimie.ro/Articles.asp?ID=7801)
Keywords: antidiabetic contaminants; liquid chromatography-mass spectrometry; wastewater

RIS
TY - JOUR
T1 - SPE-LC/MS/MS Method for Detection of Antidiabetic Contaminants in Municipal and Rural Wastewater
A1 - Iancu, Vasile-Ion
A2 - Radu, Gabriel-Lucian
A3 - Scutariu, Roxana
A4 - Chiriac, Laura-Florentina
A5 - Galaon, Toma
A6 - Petre, Jana
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2019
VL - 70
IS - 12
SP - 4607
EP - 4613
UR - https://doi.org/10.37358/RC.19.12.7801
KW - antidiabetic contaminants
KW - liquid chromatography-mass spectrometry
KW - wastewater
ER -

BibTex
@article{RevCh2019P4607,
author = {Iancu Vasile-Ion and Radu Gabriel-Lucian and Scutariu Roxana and Chiriac Laura-Florentina and Galaon Toma and Petre Jana},
title = {SPE-LC/MS/MS Method for Detection of Antidiabetic Contaminants in Municipal and Rural Wastewater},
journal = {Revista de Chimie},
volume = {70},
number = {12},
pages = {4607-4613},
year = {2019},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.19.12.7801},
url = {https://revistadechimie.ro/Articles.asp?ID=7801}
}

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