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REVISTA DE CHIMIE
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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2020, Volume 71, Issue 1, 150-154

https://doi.org/10.37358/RC.20.1.7826

Luminita Hritcu, Ilie Ovidiu Dumitru, Manuela Padurariu, Alin Ciobica, Mihaela Claudia Spataru, Constantin Spataru, Gabriela Stefanescu, Cristinel Stefanescu, Cristian Grecu-Gabos

The Modulation of Oxytocin and Cortisol Levels in Major Depression Disorder and Irritable Bowel Syndrome

Abstract:

There is a progressive trend in the current literature in understanding the central effects of oxytocin, which besides its classical roles in parturition and lactation, seems to exert some facilitatory effects in most of the neuropsychiatric disorders. Thus, it seems that oxytocin is mainly linked to the neuropsychiatric disorders where the social component is more or less affected and it has also strong correlations with the stress-related mechanisms and hypothalamic-pituitary-adrenal (HPA) axis. In addition, the connections between oxytocin and the digestive system were previously suggested, including by some of our preliminary results, in the context of irritable bowel syndrome (IBS) pathology. Also, the relations between depression and stress in the context of cortisol implications are quite well described, although various modifications of cortisol (increased, decreased or non-modified) were described in the major depression pathology. Thus, by using two research cohorts: one with major depression disorder (n = 15) and another one having both diagnosis of major depression disorder and irritable bowel syndrome in the same time (n = 15), we are showing in this report significantly increased levels of cortisol in patients with MDD and IBS, when compared with patients with MDD without IBS, while an opposite pattern was obtained by measuring the plasma level of oxytocin, where the patients with MDD and IBS had a significantly decreased concentration of oxytocin, as compared with those with MDD but without IBS.
Keywords:
oxytocin; cortisol; depression; irritable bowel syndrome

Issue: 2020, Volume 71, Issue 1
Pages: 150-154
Publication date: 2020/2/7
https://doi.org/10.37358/RC.20.1.7826
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
HRITCU, L., DUMITRU, I.O., PADURARIU, M., CIOBICA, A., SPATARU, M.C., SPATARU, C., STEFANESCU, G., STEFANESCU, C., GRECU-GABOS, C., The Modulation of Oxytocin and Cortisol Levels in Major Depression Disorder and Irritable Bowel Syndrome, Rev. Chim., 71(1), 2020, 150-154.

Vancouver
Hritcu L, Dumitru IO, Padurariu M, Ciobica A, Spataru MC, Spataru C, Stefanescu G, Stefanescu C, Grecu-Gabos C. The Modulation of Oxytocin and Cortisol Levels in Major Depression Disorder and Irritable Bowel Syndrome. Rev. Chim.[internet]. 2020 Jan;71(1):150-154. Available from: https://doi.org/10.37358/RC.20.1.7826


APA 6th edition
Hritcu, L., Dumitru, I.O., Padurariu, M., Ciobica, A., Spataru, M.C., Spataru, C.,... Grecu-Gabos, C. (2020). The Modulation of Oxytocin and Cortisol Levels in Major Depression Disorder and Irritable Bowel Syndrome. Revista de Chimie, 71(1), 150-154. https://doi.org/10.37358/RC.20.1.7826


Harvard
Hritcu, L., Dumitru, I.O., Padurariu, M., Ciobica, A., Spataru, M.C., Spataru, C., Stefanescu, G., Stefanescu, C., Grecu-Gabos, C. (2020). 'The Modulation of Oxytocin and Cortisol Levels in Major Depression Disorder and Irritable Bowel Syndrome', Revista de Chimie, 71(1), pp. 150-154. https://doi.org/10.37358/RC.20.1.7826


IEEE
L. Hritcu, I.O. Dumitru, M. Padurariu, A. Ciobica, M.C. Spataru, C. Spataru, G. Stefanescu, C. Stefanescu, C. Grecu-Gabos, "The Modulation of Oxytocin and Cortisol Levels in Major Depression Disorder and Irritable Bowel Syndrome". Revista de Chimie, vol. 71, no. 1, pp. 150-154, 2020. [online]. https://doi.org/10.37358/RC.20.1.7826


Text
Luminita Hritcu, Ilie Ovidiu Dumitru, Manuela Padurariu, Alin Ciobica, Mihaela Claudia Spataru, Constantin Spataru, Gabriela Stefanescu, Cristinel Stefanescu, Cristian Grecu-Gabos,
The Modulation of Oxytocin and Cortisol Levels in Major Depression Disorder and Irritable Bowel Syndrome,
Revista de Chimie,
Volume 71, Issue 1,
2020,
Pages 150-154,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.1.7826.
(https://revistadechimie.ro/Articles.asp?ID=7826)
Keywords: oxytocin; cortisol; depression; irritable bowel syndrome


RIS
TY - JOUR
T1 - The Modulation of Oxytocin and Cortisol Levels in Major Depression Disorder and Irritable Bowel Syndrome
A1 - Hritcu, Luminita
A2 - Dumitru, Ilie Ovidiu
A3 - Padurariu, Manuela
A4 - Ciobica, Alin
A5 - Spataru, Mihaela Claudia
A6 - Spataru, Constantin
A7 - Stefanescu, Gabriela
A8 - Stefanescu, Cristinel
A9 - Grecu-Gabos, Cristian
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 1
SP - 150
EP - 154
UR - https://doi.org/10.37358/RC.20.1.7826
KW - oxytocin
KW - cortisol
KW - depression
KW - irritable bowel syndrome
ER -


BibTex
@article{RevCh2020P150,
author = {Hritcu Luminita and Dumitru Ilie Ovidiu and Padurariu Manuela and Ciobica Alin and Spataru Mihaela Claudia and Spataru Constantin and Stefanescu Gabriela and Stefanescu Cristinel and Grecu-Gabos Cristian},
title = {The Modulation of Oxytocin and Cortisol Levels in Major Depression Disorder and Irritable Bowel Syndrome},
journal = {Revista de Chimie},
volume = {71},
number = {1},
pages = {150-154},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.1.7826},
url = {https://revistadechimie.ro/Articles.asp?ID=7826}
}
 
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