Zsombor Panti, Bogdan Cretu, Corina Panaitescu, Mihai Nica, Camelia Tecu, Augustin Semenescu, Dragos Ene, Razvan Ene
Implant Associated Local Recurrence in Primary Bone Sarcoma
Abstract:
Hydroxyapatite (HA) covered implants are widely used in orthopedic reconstructive surgery. Their biological benefits were highlighted by several studies in the past decades in which the most important ones are the osteoconductive and osteoinductive capacity, which enhances osteoblast adherence, proliferation and bone extracellular matrix formation. In bone sarcomas the micro-environmental changes are crucial for tumor growth, new bone formation especially in osteoblastic osteosarcomas (OS). Nowadays limb sparing surgery and maintaining the quality of patient’s life are the main two goals in bone sarcoma treatment. The survival rate of patients with OS has been significantly improved in the past 3-4 decades due to the advanced chemotherapy protocols. The prognosis still depends on the early diagnosis and the histological type of the sarcoma. Tumor removal and reconstruction is a crucial moment for prognosis, studies showed that high grade sarcomas have a greater potential for local recurrence and early distant metastases. Metastasis can occur in early stages, even if there are not detectable at the time of surgery. Furthermore, the micro-environmental changes can facilitate sarcoma cell proliferation even if the tumor resection was performed in macroscopically normal bone tissue. We present a case of osteosarcoma in which local recurrence has occurred despite of chemotherapy and wide resection of the tumor. We can ask the following question can an implant increases the risk of local recurrence in sarcoma surgerys The aim of the study was to understand the underlying molecular pathway for sarcoma cell proliferation in HA covered implants.
Keywords: Hydroxyapatite; osteosarcoma; local recurrence
Cite this article as: PANTI, Z., CRETU, B., PANAITESCU, C., NICA, M., TECU, C., SEMENESCU, A., ENE, D., ENE, R., Implant Associated Local Recurrence in Primary Bone Sarcoma, Rev. Chim., 71(1), 2020, 172-175.
Vancouver Panti Z, Cretu B, Panaitescu C, Nica M, Tecu C, Semenescu A, Ene D, Ene R. Implant Associated Local Recurrence in Primary Bone Sarcoma. Rev. Chim.[internet]. 2020 Jan;71(1):172-175. Available from: https://doi.org/10.37358/RC.20.1.7828
APA 6th edition Panti, Z., Cretu, B., Panaitescu, C., Nica, M., Tecu, C., Semenescu, A., Ene, D. & Ene, R. (2020). Implant Associated Local Recurrence in Primary Bone Sarcoma. Revista de Chimie, 71(1), 172-175. https://doi.org/10.37358/RC.20.1.7828
Harvard Panti, Z., Cretu, B., Panaitescu, C., Nica, M., Tecu, C., Semenescu, A., Ene, D., Ene, R. (2020). 'Implant Associated Local Recurrence in Primary Bone Sarcoma', Revista de Chimie, 71(1), pp. 172-175. https://doi.org/10.37358/RC.20.1.7828
IEEE Z. Panti, B. Cretu, C. Panaitescu, M. Nica, C. Tecu, A. Semenescu, D. Ene, R. Ene, "Implant Associated Local Recurrence in Primary Bone Sarcoma". Revista de Chimie, vol. 71, no. 1, pp. 172-175, 2020. [online]. https://doi.org/10.37358/RC.20.1.7828
Text Zsombor Panti, Bogdan Cretu, Corina Panaitescu, Mihai Nica, Camelia Tecu, Augustin Semenescu, Dragos Ene, Razvan Ene, Implant Associated Local Recurrence in Primary Bone Sarcoma, Revista de Chimie, Volume 71, Issue 1, 2020, Pages 172-175, ISSN 2668-8212, https://doi.org/10.37358/RC.20.1.7828. (https://revistadechimie.ro/Articles.asp?ID=7828) Keywords: Hydroxyapatite; osteosarcoma; local recurrence
RIS TY - JOUR T1 - Implant Associated Local Recurrence in Primary Bone Sarcoma A1 - Panti, Zsombor A2 - Cretu, Bogdan A3 - Panaitescu, Corina A4 - Nica, Mihai A5 - Tecu, Camelia A6 - Semenescu, Augustin A7 - Ene, Dragos A8 - Ene, Razvan JF - Revista de Chimie JO - Rev. Chim. PB - Revista de Chimie SRL SN - 2668-8212 Y1 - 2020 VL - 71 IS - 1 SP - 172 EP - 175 UR - https://doi.org/10.37358/RC.20.1.7828 KW - Hydroxyapatite KW - osteosarcoma KW - local recurrence ER -
BibTex @article{RevCh2020P172, author = {Panti Zsombor and Cretu Bogdan and Panaitescu Corina and Nica Mihai and Tecu Camelia and Semenescu Augustin and Ene Dragos and Ene Razvan}, title = {Implant Associated Local Recurrence in Primary Bone Sarcoma}, journal = {Revista de Chimie}, volume = {71}, number = {1}, pages = {172-175}, year = {2020}, issn = {2668-8212}, doi = {https://doi.org/10.37358/RC.20.1.7828}, url = {https://revistadechimie.ro/Articles.asp?ID=7828} }
