Implant Associated Local Recurrence in Primary Bone Sarcoma

Panti, Zsombor; Cretu, Bogdan; Panaitescu, Corina; Nica, Mihai; Tecu, Camelia; Semenescu, Augustin; Ene, Dragos; Ene, Razvan

Zsombor Panti, Bogdan Cretu, Corina Panaitescu, Mihai Nica, Camelia Tecu, Augustin Semenescu, Dragos Ene, Razvan Ene

Implant Associated Local Recurrence in Primary Bone Sarcoma

Abstract:

Hydroxyapatite (HA) covered implants are widely used in orthopedic reconstructive surgery. Their biological benefits were highlighted by several studies in the past decades in which the most important ones are the osteoconductive and osteoinductive capacity, which enhances osteoblast adherence, proliferation and bone extracellular matrix formation. In bone sarcomas the micro-environmental changes are crucial for tumor growth, new bone formation especially in osteoblastic osteosarcomas (OS). Nowadays limb sparing surgery and maintaining the quality of patient’s life are the main two goals in bone sarcoma treatment. The survival rate of patients with OS has been significantly improved in the past 3-4 decades due to the advanced chemotherapy protocols. The prognosis still depends on the early diagnosis and the histological type of the sarcoma. Tumor removal and reconstruction is a crucial moment for prognosis, studies showed that high grade sarcomas have a greater potential for local recurrence and early distant metastases. Metastasis can occur in early stages, even if there are not detectable at the time of surgery. Furthermore, the micro-environmental changes can facilitate sarcoma cell proliferation even if the tumor resection was performed in macroscopically normal bone tissue. We present a case of osteosarcoma in which local recurrence has occurred despite of chemotherapy and wide resection of the tumor. We can ask the following question can an implant increases the risk of local recurrence in sarcoma surgerys The aim of the study was to understand the underlying molecular pathway for sarcoma cell proliferation in HA covered implants.

Keywords:
Hydroxyapatite; osteosarcoma; local recurrence

Issue: 2020, Volume 71, Issue 1

Pages: 172-175

Publication date: 2020/2/7

https://doi.org/10.37358/RC.20.1.7828

Download Pdf Article

This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
PANTI, Z., CRETU, B., PANAITESCU, C., NICA, M., TECU, C., SEMENESCU, A., ENE, D., ENE, R., Implant Associated Local Recurrence in Primary Bone Sarcoma, Rev. Chim., 71(1), 2020, 172-175.

Vancouver
Panti Z, Cretu B, Panaitescu C, Nica M, Tecu C, Semenescu A, Ene D, Ene R. Implant Associated Local Recurrence in Primary Bone Sarcoma. Rev. Chim.[internet]. 2020 Jan;71(1):172-175. Available from: https://doi.org/10.37358/RC.20.1.7828

APA 6th edition
Panti, Z., Cretu, B., Panaitescu, C., Nica, M., Tecu, C., Semenescu, A., Ene, D. & Ene, R. (2020). Implant Associated Local Recurrence in Primary Bone Sarcoma. Revista de Chimie, 71(1), 172-175. https://doi.org/10.37358/RC.20.1.7828

Harvard
Panti, Z., Cretu, B., Panaitescu, C., Nica, M., Tecu, C., Semenescu, A., Ene, D., Ene, R. (2020). 'Implant Associated Local Recurrence in Primary Bone Sarcoma', Revista de Chimie, 71(1), pp. 172-175. https://doi.org/10.37358/RC.20.1.7828

IEEE
Z. Panti, B. Cretu, C. Panaitescu, M. Nica, C. Tecu, A. Semenescu, D. Ene, R. Ene, "Implant Associated Local Recurrence in Primary Bone Sarcoma". Revista de Chimie, vol. 71, no. 1, pp. 172-175, 2020. [online]. https://doi.org/10.37358/RC.20.1.7828

Text
Zsombor Panti, Bogdan Cretu, Corina Panaitescu, Mihai Nica, Camelia Tecu, Augustin Semenescu, Dragos Ene, Razvan Ene,
Implant Associated Local Recurrence in Primary Bone Sarcoma,
Revista de Chimie,
Volume 71, Issue 1,
2020,
Pages 172-175,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.1.7828.
(https://revistadechimie.ro/Articles.asp?ID=7828)
Keywords: Hydroxyapatite; osteosarcoma; local recurrence

RIS
TY - JOUR
T1 - Implant Associated Local Recurrence in Primary Bone Sarcoma
A1 - Panti, Zsombor
A2 - Cretu, Bogdan
A3 - Panaitescu, Corina
A4 - Nica, Mihai
A5 - Tecu, Camelia
A6 - Semenescu, Augustin
A7 - Ene, Dragos
A8 - Ene, Razvan
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 1
SP - 172
EP - 175
UR - https://doi.org/10.37358/RC.20.1.7828
KW - Hydroxyapatite
KW - osteosarcoma
KW - local recurrence
ER -

BibTex
@article{RevCh2020P172,
author = {Panti Zsombor and Cretu Bogdan and Panaitescu Corina and Nica Mihai and Tecu Camelia and Semenescu Augustin and Ene Dragos and Ene Razvan},
title = {Implant Associated Local Recurrence in Primary Bone Sarcoma},
journal = {Revista de Chimie},
volume = {71},
number = {1},
pages = {172-175},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.1.7828},
url = {https://revistadechimie.ro/Articles.asp?ID=7828}
}

<<<< back

PUBLISHING SECTION

Author Guidelines

* Paper Drafting

* Paper Template

* Ethical Statement

* Paper Submission

Ghidul Autorului (ro)

Open Access & Archiving Policy

Search Authors

LATEST NEWS
	NUMAR OMAGIAL PETRU PONI.. detalii
	Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
	English-Romanian Dictionary for Mechanical Engineering (download pdf)