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Revista de Chimie (Rev. Chim.), Year 2020, Volume 71, Issue 1, 206-212

https://doi.org/10.37358/RC.20.1.7833

Amina Mumtaz, Tariq Mahmud, M. R. J. Elsegood, G. W. Weaver, Gabriel Bratu, Liviu Mitu

Synthesis, Characterization and Biological Evaluation of Schiff Base (N-4-(thiophene-2-yl-methyleneamino)-2,6-dimethylpyrimidine-4-yl)benzenesulfonamide and its Complexes with Cu(II), Ni(II), Co(II), Fe(II), Mn(II), Zn(II) Ions

Abstract:

Two step synthesis of Schiff base ligand and its transition metal complexes was done by condensation reaction. In first step, the drug and aldehyde in equimolar ratio were refluxed for one hour at pH 8-9 in order to get Schiff base ligand. In second step, ligand and metal salts were refluxed for 2 hour. The ligand and Cu(II), Ni(II), Co(II), Fe(II), Mn(II), Zn(II) complexes were characterized by using different instruments like FT-IR, 1H-NMR, 13C-NMR, Mass, Atomic absorption spectrometer, Elemental analyzer, UV-visible spectrophotometer, Evans balance, Conductivitymeter and Thermogravimeter. In vitro antibacterial, antifungal and anti-inflammatory activities were also studied. The synthesized ligand and transition metal complexes were tested against Escherichia coli, Enterobacter aerogenes, Staphylococcus aureus, Bacillus pumilus, Klebsiella oxytoca, Clostridium butyrium, Mucor and Aspergillus niger. These studies demonstrated the enhanced activity of metal complexes against reported bacterial and fungal strains when compared with free Schiff base ligand. The Cu(II) complex recognized as anti-inflammatory agent while the parent drug showed no activity.
Keywords:
Schiff base; metal complex; sulfisomidine; thiophene-2-carboxaldehyde; bacteria; fungi

Issue: 2020, Volume 71, Issue 1
Pages: 206-212
Publication date: 2020/2/7
https://doi.org/10.37358/RC.20.1.7833
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
MUMTAZ, A., MAHMUD, T., ELSEGOOD, M.R.J., WEAVER, G.W., BRATU, G., MITU, L., Synthesis, Characterization and Biological Evaluation of Schiff Base (N-4-(thiophene-2-yl-methyleneamino)-2,6-dimethylpyrimidine-4-yl)benzenesulfonamide and its Complexes with Cu(II), Ni(II), Co(II), Fe(II), Mn(II), Zn(II) Ions, Rev. Chim., 71(1), 2020, 206-212.

Vancouver
Mumtaz A, Mahmud T, Elsegood MRJ, Weaver GW, Bratu G, Mitu L. Synthesis, Characterization and Biological Evaluation of Schiff Base (N-4-(thiophene-2-yl-methyleneamino)-2,6-dimethylpyrimidine-4-yl)benzenesulfonamide and its Complexes with Cu(II), Ni(II), Co(II), Fe(II), Mn(II), Zn(II) Ions. Rev. Chim.[internet]. 2020 Jan;71(1):206-212. Available from: https://doi.org/10.37358/RC.20.1.7833


APA 6th edition
Mumtaz, A., Mahmud, T., Elsegood, M.R.J., Weaver, G.W., Bratu, G. & Mitu, L. (2020). Synthesis, Characterization and Biological Evaluation of Schiff Base (N-4-(thiophene-2-yl-methyleneamino)-2,6-dimethylpyrimidine-4-yl)benzenesulfonamide and its Complexes with Cu(II), Ni(II), Co(II), Fe(II), Mn(II), Zn(II) Ions. Revista de Chimie, 71(1), 206-212. https://doi.org/10.37358/RC.20.1.7833


Harvard
Mumtaz, A., Mahmud, T., Elsegood, M.R.J., Weaver, G.W., Bratu, G., Mitu, L. (2020). 'Synthesis, Characterization and Biological Evaluation of Schiff Base (N-4-(thiophene-2-yl-methyleneamino)-2,6-dimethylpyrimidine-4-yl)benzenesulfonamide and its Complexes with Cu(II), Ni(II), Co(II), Fe(II), Mn(II), Zn(II) Ions', Revista de Chimie, 71(1), pp. 206-212. https://doi.org/10.37358/RC.20.1.7833


IEEE
A. Mumtaz, T. Mahmud, M.R.J. Elsegood, G.W. Weaver, G. Bratu, L. Mitu, "Synthesis, Characterization and Biological Evaluation of Schiff Base (N-4-(thiophene-2-yl-methyleneamino)-2,6-dimethylpyrimidine-4-yl)benzenesulfonamide and its Complexes with Cu(II), Ni(II), Co(II), Fe(II), Mn(II), Zn(II) Ions". Revista de Chimie, vol. 71, no. 1, pp. 206-212, 2020. [online]. https://doi.org/10.37358/RC.20.1.7833


Text
Amina Mumtaz, Tariq Mahmud, M. R. J. Elsegood, G. W. Weaver, Gabriel Bratu, Liviu Mitu,
Synthesis, Characterization and Biological Evaluation of Schiff Base (N-4-(thiophene-2-yl-methyleneamino)-2,6-dimethylpyrimidine-4-yl)benzenesulfonamide and its Complexes with Cu(II), Ni(II), Co(II), Fe(II), Mn(II), Zn(II) Ions,
Revista de Chimie,
Volume 71, Issue 1,
2020,
Pages 206-212,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.1.7833.
(https://revistadechimie.ro/Articles.asp?ID=7833)
Keywords: Schiff base; metal complex; sulfisomidine; thiophene-2-carboxaldehyde; bacteria; fungi


RIS
TY - JOUR
T1 - Synthesis, Characterization and Biological Evaluation of Schiff Base (N-4-(thiophene-2-yl-methyleneamino)-2,6-dimethylpyrimidine-4-yl)benzenesulfonamide and its Complexes with Cu(II), Ni(II), Co(II), Fe(II), Mn(II), Zn(II) Ions
A1 - Mumtaz, Amina
A2 - Mahmud, Tariq
A3 - Elsegood, M. R. J.
A4 - Weaver, G. W.
A5 - Bratu, Gabriel
A6 - Mitu, Liviu
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 1
SP - 206
EP - 212
UR - https://doi.org/10.37358/RC.20.1.7833
KW - Schiff base
KW - metal complex
KW - sulfisomidine
KW - thiophene-2-carboxaldehyde
KW - bacteria
KW - fungi
ER -


BibTex
@article{RevCh2020P206,
author = {Mumtaz Amina and Mahmud Tariq and Elsegood M. R. J. and Weaver G. W. and Bratu Gabriel and Mitu Liviu},
title = {Synthesis, Characterization and Biological Evaluation of Schiff Base (N-4-(thiophene-2-yl-methyleneamino)-2,6-dimethylpyrimidine-4-yl)benzenesulfonamide and its Complexes with Cu(II), Ni(II), Co(II), Fe(II), Mn(II), Zn(II) Ions},
journal = {Revista de Chimie},
volume = {71},
number = {1},
pages = {206-212},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.1.7833},
url = {https://revistadechimie.ro/Articles.asp?ID=7833}
}
 
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