Expression of PIGF and sFLT-1 Biomarkers in Pregnancy Toxaemia

Mihalceanu, Elena; Scripcariu, Ioana Sadyre; Lazar, Ioan Tudor; Pangal, Alexandra; Adam, Ana Maria; Bulimar, Virgil; Dimitriu, Cristina Daniela; Negru, Irina

Elena Mihalceanu, Ioana Sadyre Scripcariu, Ioan Tudor Lazar, Alexandra Pangal, Ana Maria Adam, Virgil Bulimar, Cristina Daniela Dimitriu, Irina Negru

Expression of PIGF and sFLT-1 Biomarkers in Pregnancy Toxaemia

Abstract:

Toxaemia is a pathological condition specific to the period of pregnancy which begins and is indissolubly related to the presence of placenta. Antiangiogenic factors, such as sFLT-1 (soluble tyrosine kinase receptor fms-like) and sEng (soluble endoglin) play an important role in the first part of pregnancy. They are linked to physiological vascular neoformation, and, in the second part of the pregnancy, grant the endothelial functionality and physiological vascular remodeling. The aim of the study is to try to establish the levels of the sFLT- 1/PIGF ratio, as a prognostic tool in the patient with pre-eclampsia, depending on the influence of the cumulative risk factors. The sFLT-1 / PIGF report is a potential prognostic parameter in monitoring preeclampsia. The results of our study confirm the importance of deterring these markers for the diagnosis and monitoring of hypertensive pregnancies and at the same time to emphasize that the sFLT-1/PIGF ratio is a good predictor of preeclampsia.

Keywords:
pregnancy; antiangiogenic factors; toxaemia

Issue: 2020, Volume 71, Issue 1

Pages: 450-457

Publication date: 2020/2/7

https://doi.org/10.37358/RC.20.1.7874

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
MIHALCEANU, E., SCRIPCARIU, I.S., LAZAR, I.T., PANGAL, A., ADAM, A.M., BULIMAR, V., DIMITRIU, C.D., NEGRU, I., Expression of PIGF and sFLT-1 Biomarkers in Pregnancy Toxaemia, Rev. Chim., 71(1), 2020, 450-457.

Vancouver
Mihalceanu E, Scripcariu IS, Lazar IT, Pangal A, Adam AM, Bulimar V, Dimitriu CD, Negru I. Expression of PIGF and sFLT-1 Biomarkers in Pregnancy Toxaemia. Rev. Chim.[internet]. 2020 Jan;71(1):450-457. Available from: https://doi.org/10.37358/RC.20.1.7874

APA 6th edition
Mihalceanu, E., Scripcariu, I.S., Lazar, I.T., Pangal, A., Adam, A.M., Bulimar, V., Dimitriu, C.D. & Negru, I. (2020). Expression of PIGF and sFLT-1 Biomarkers in Pregnancy Toxaemia. Revista de Chimie, 71(1), 450-457. https://doi.org/10.37358/RC.20.1.7874

Harvard
Mihalceanu, E., Scripcariu, I.S., Lazar, I.T., Pangal, A., Adam, A.M., Bulimar, V., Dimitriu, C.D., Negru, I. (2020). 'Expression of PIGF and sFLT-1 Biomarkers in Pregnancy Toxaemia', Revista de Chimie, 71(1), pp. 450-457. https://doi.org/10.37358/RC.20.1.7874

IEEE
E. Mihalceanu, I.S. Scripcariu, I.T. Lazar, A. Pangal, A.M. Adam, V. Bulimar, C.D. Dimitriu, I. Negru, "Expression of PIGF and sFLT-1 Biomarkers in Pregnancy Toxaemia". Revista de Chimie, vol. 71, no. 1, pp. 450-457, 2020. [online]. https://doi.org/10.37358/RC.20.1.7874

Text
Elena Mihalceanu, Ioana Sadyre Scripcariu, Ioan Tudor Lazar, Alexandra Pangal, Ana Maria Adam, Virgil Bulimar, Cristina Daniela Dimitriu, Irina Negru,
Expression of PIGF and sFLT-1 Biomarkers in Pregnancy Toxaemia,
Revista de Chimie,
Volume 71, Issue 1,
2020,
Pages 450-457,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.1.7874.
(https://revistadechimie.ro/Articles.asp?ID=7874)
Keywords: pregnancy; antiangiogenic factors; toxaemia

RIS
TY - JOUR
T1 - Expression of PIGF and sFLT-1 Biomarkers in Pregnancy Toxaemia
A1 - Mihalceanu, Elena
A2 - Scripcariu, Ioana Sadyre
A3 - Lazar, Ioan Tudor
A4 - Pangal, Alexandra
A5 - Adam, Ana Maria
A6 - Bulimar, Virgil
A7 - Dimitriu, Cristina Daniela
A8 - Negru, Irina
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 1
SP - 450
EP - 457
UR - https://doi.org/10.37358/RC.20.1.7874
KW - pregnancy
KW - antiangiogenic factors
KW - toxaemia
ER -

BibTex
@article{RevCh2020P450,
author = {Mihalceanu Elena and Scripcariu Ioana Sadyre and Lazar Ioan Tudor and Pangal Alexandra and Adam Ana Maria and Bulimar Virgil and Dimitriu Cristina Daniela and Negru Irina},
title = {Expression of PIGF and sFLT-1 Biomarkers in Pregnancy Toxaemia},
journal = {Revista de Chimie},
volume = {71},
number = {1},
pages = {450-457},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.1.7874},
url = {https://revistadechimie.ro/Articles.asp?ID=7874}
}

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