Neutrophil Gelatinase-associated Lipocalin (NGAL) a Promising Biomarker for Early Detection of Nephrotoxic Injury

Ulmeanu, Alexandru-Ioan; Ghita, Isabel; Ulmeanu, Coriolan

Alexandru-Ioan Ulmeanu, Isabel Ghita, Coriolan Ulmeanu

Neutrophil Gelatinase-associated Lipocalin (NGAL) a Promising Biomarker for Early Detection of Nephrotoxic Injury

Abstract:

Renal toxic injury can neither be predicted nor quantified exactly by the serum creatinine level. NGAL is a promising biomarker for early detection of AKI due to different causes. Our objective was to evaluate it’s value in the setting of nephrotoxic injury. We performed an experiment in which we administered gentamicin, atropine and fipronil at different doses to the laboratory mice to quantify the evolution of creatinine and NGAL. Compared to creatinine, NGAL increased faster and was detected at elevated levels from the first 4 h after administration of both low and high dose gentamicin. Fipronil, atropine and the combination caused a significant increase in NGAL serum values at 4 hours, an increase that lasted up to 24 and 72 h , respectively, compared to the control group, Its highest levels were recorded at 4 h. Compared to creatinine, NGAL increased faster and was detected at elevated levels from the first 4 h after administration of fipronil, atropine and the combination of them.

Keywords:
NGAL; neutrophil gelatinase-associated lipocalin; acute kidney injury; nephrotoxic

Issue: 2020, Volume 71, Issue 2

Pages: 15-21

Publication date: 2020/3/3

https://doi.org/10.37358/RC.20.2.7885

Download Pdf Article

This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
ULMEANU, A., GHITA, I., ULMEANU, C., Neutrophil Gelatinase-associated Lipocalin (NGAL) a Promising Biomarker for Early Detection of Nephrotoxic Injury, Rev. Chim., 71(2), 2020, 15-21.

Vancouver
Ulmeanu A, Ghita I, Ulmeanu C. Neutrophil Gelatinase-associated Lipocalin (NGAL) a Promising Biomarker for Early Detection of Nephrotoxic Injury. Rev. Chim.[internet]. 2020 Feb;71(2):15-21. Available from: https://doi.org/10.37358/RC.20.2.7885

APA 6th edition
Ulmeanu, A., Ghita, I. & Ulmeanu, C. (2020). Neutrophil Gelatinase-associated Lipocalin (NGAL) a Promising Biomarker for Early Detection of Nephrotoxic Injury. Revista de Chimie, 71(2), 15-21. https://doi.org/10.37358/RC.20.2.7885

Harvard
Ulmeanu, A., Ghita, I., Ulmeanu, C. (2020). 'Neutrophil Gelatinase-associated Lipocalin (NGAL) a Promising Biomarker for Early Detection of Nephrotoxic Injury', Revista de Chimie, 71(2), pp. 15-21. https://doi.org/10.37358/RC.20.2.7885

IEEE
A. Ulmeanu, I. Ghita, C. Ulmeanu, "Neutrophil Gelatinase-associated Lipocalin (NGAL) a Promising Biomarker for Early Detection of Nephrotoxic Injury". Revista de Chimie, vol. 71, no. 2, pp. 15-21, 2020. [online]. https://doi.org/10.37358/RC.20.2.7885

Text
Alexandru-Ioan Ulmeanu, Isabel Ghita, Coriolan Ulmeanu,
Neutrophil Gelatinase-associated Lipocalin (NGAL) a Promising Biomarker for Early Detection of Nephrotoxic Injury,
Revista de Chimie,
Volume 71, Issue 2,
2020,
Pages 15-21,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.2.7885.
(https://revistadechimie.ro/Articles.asp?ID=7885)
Keywords: NGAL; neutrophil gelatinase-associated lipocalin; acute kidney injury; nephrotoxic

RIS
TY - JOUR
T1 - Neutrophil Gelatinase-associated Lipocalin (NGAL) a Promising Biomarker for Early Detection of Nephrotoxic Injury
A1 - Ulmeanu, Alexandru-Ioan
A2 - Ghita, Isabel
A3 - Ulmeanu, Coriolan
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 2
SP - 15
EP - 21
UR - https://doi.org/10.37358/RC.20.2.7885
KW - NGAL
KW - neutrophil gelatinase-associated lipocalin
KW - acute kidney injury
KW - nephrotoxic
ER -

BibTex
@article{RevCh2020P15,
author = {Ulmeanu Alexandru-Ioan and Ghita Isabel and Ulmeanu Coriolan},
title = {Neutrophil Gelatinase-associated Lipocalin (NGAL) a Promising Biomarker for Early Detection of Nephrotoxic Injury},
journal = {Revista de Chimie},
volume = {71},
number = {2},
pages = {15-21},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.2.7885},
url = {https://revistadechimie.ro/Articles.asp?ID=7885}
}

<<<< back

PUBLISHING SECTION

Author Guidelines

* Paper Drafting

* Paper Template

* Ethical Statement

* Paper Submission

Ghidul Autorului (ro)

Open Access & Archiving Policy

Search Authors

LATEST NEWS
	NUMAR OMAGIAL PETRU PONI.. detalii
	Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
	English-Romanian Dictionary for Mechanical Engineering (download pdf)