The Cytotoxic Effect of Rtks Inhibitors on Glioblastoma Cells. A Mathematical Model for Treatment Protocols Optimization

Brandusa, Corina; Vatu, Bogdan-Ionel; Purcaru, Stefana Oana; Artene, Stefan-Alexandru; Buteica, Sandra Alice; Tache, Daniela Elise; Silosi, Cristian Adrian; Taisescu, Citto Iulian; Alexandru, Oana; Stovicek, Olivian Puiu; Demetrian, Alin; Dricu, Anica

Corina Brandusa, Bogdan-Ionel Vatu, Stefana Oana Purcaru, Stefan-Alexandru Artene, Sandra Alice Buteica, Daniela Elise Tache, Cristian Adrian Silosi, Citto Iulian Taisescu, Oana Alexandru, Olivian Puiu Stovicek, Alin Demetrian, Anica Dricu

The Cytotoxic Effect of Rtks Inhibitors on Glioblastoma Cells. A Mathematical Model for Treatment Protocols Optimization

Abstract:

Medical oncology has seen an exponential growth in the last 20 years with the vast majority of malignancies receiving new therapeutic options with substantial benefits to patients’ survival and quality of life. Glioblastomas (GBMs), however, have remained largely incurable, with over 90% of patients dying within 5 years of diagnosis. The estimation of a dose-effect type ratio, regarding the action of an oncological drug on tumor cells, leads to relevant conclusions in establishing the optimal medication, specific to the chemotherapeutic act. The identification of the optimal dose of agent is very important, based on experiments on cell lines with regards to cellular kinetics. In this study, we developed a mathematical model based on the specific transfer function of a dose-response action type of a drug on tumor cells in vitro.

Keywords:
mathematical model; glioblastoma; simulation

Issue: 2020, Volume 71, Issue 2

Pages: 115-120

Publication date: 2020/3/3

https://doi.org/10.37358/RC.20.2.7903

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
BRANDUSA, C., VATU, B., PURCARU, S.O., ARTENE, S., BUTEICA, S.A., TACHE, D.E., SILOSI, C.A., TAISESCU, C.I., ALEXANDRU, O., STOVICEK, O.P., DEMETRIAN, A., DRICU, A., The Cytotoxic Effect of Rtks Inhibitors on Glioblastoma Cells. A Mathematical Model for Treatment Protocols Optimization, Rev. Chim., 71(2), 2020, 115-120.

Vancouver
Brandusa C, Vatu B, Purcaru SO, Artene S, Buteica SA, Tache DE, Silosi CA, Taisescu CI, Alexandru O, Stovicek OP, Demetrian A, Dricu A. The Cytotoxic Effect of Rtks Inhibitors on Glioblastoma Cells. A Mathematical Model for Treatment Protocols Optimization. Rev. Chim.[internet]. 2020 Feb;71(2):115-120. Available from: https://doi.org/10.37358/RC.20.2.7903

APA 6th edition
Brandusa, C., Vatu, B., Purcaru, S.O., Artene, S., Buteica, S.A., Tache, D.E.,... Dricu, A. (2020). The Cytotoxic Effect of Rtks Inhibitors on Glioblastoma Cells. A Mathematical Model for Treatment Protocols Optimization. Revista de Chimie, 71(2), 115-120. https://doi.org/10.37358/RC.20.2.7903

Harvard
Brandusa, C., Vatu, B., Purcaru, S.O., Artene, S., Buteica, S.A., Tache, D.E., Silosi, C.A., Taisescu, C.I., Alexandru, O., Stovicek, O.P., Demetrian, A., Dricu, A. (2020). 'The Cytotoxic Effect of Rtks Inhibitors on Glioblastoma Cells. A Mathematical Model for Treatment Protocols Optimization', Revista de Chimie, 71(2), pp. 115-120. https://doi.org/10.37358/RC.20.2.7903

IEEE
C. Brandusa, B. Vatu, S.O. Purcaru, S. Artene, S.A. Buteica, D.E. Tache, C.A. Silosi, C.I. Taisescu, O. Alexandru, O.P. Stovicek, A. Demetrian, A. Dricu, "The Cytotoxic Effect of Rtks Inhibitors on Glioblastoma Cells. A Mathematical Model for Treatment Protocols Optimization". Revista de Chimie, vol. 71, no. 2, pp. 115-120, 2020. [online]. https://doi.org/10.37358/RC.20.2.7903

Text
Corina Brandusa, Bogdan-Ionel Vatu, Stefana Oana Purcaru, Stefan-Alexandru Artene, Sandra Alice Buteica, Daniela Elise Tache, Cristian Adrian Silosi, Citto Iulian Taisescu, Oana Alexandru, Olivian Puiu Stovicek, Alin Demetrian, Anica Dricu,
The Cytotoxic Effect of Rtks Inhibitors on Glioblastoma Cells. A Mathematical Model for Treatment Protocols Optimization,
Revista de Chimie,
Volume 71, Issue 2,
2020,
Pages 115-120,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.2.7903.
(https://revistadechimie.ro/Articles.asp?ID=7903)
Keywords: mathematical model; glioblastoma; simulation

RIS
TY - JOUR
T1 - The Cytotoxic Effect of Rtks Inhibitors on Glioblastoma Cells. A Mathematical Model for Treatment Protocols Optimization
A1 - Brandusa, Corina
A2 - Vatu, Bogdan-Ionel
A3 - Purcaru, Stefana Oana
A4 - Artene, Stefan-Alexandru
A5 - Buteica, Sandra Alice
A6 - Tache, Daniela Elise
A7 - Silosi, Cristian Adrian
A8 - Taisescu, Citto Iulian
A9 - Alexandru, Oana
A10 - Stovicek, Olivian Puiu
A11 - Demetrian, Alin
A12 - Dricu, Anica
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 2
SP - 115
EP - 120
UR - https://doi.org/10.37358/RC.20.2.7903
KW - mathematical model
KW - glioblastoma
KW - simulation
ER -

BibTex
@article{RevCh2020P115,
author = {Brandusa Corina and Vatu Bogdan-Ionel and Purcaru Stefana Oana and Artene Stefan-Alexandru and Buteica Sandra Alice and Tache Daniela Elise and Silosi Cristian Adrian and Taisescu Citto Iulian and Alexandru Oana and Stovicek Olivian Puiu and Demetrian Alin and Dricu Anica},
title = {The Cytotoxic Effect of Rtks Inhibitors on Glioblastoma Cells. A Mathematical Model for Treatment Protocols Optimization},
journal = {Revista de Chimie},
volume = {71},
number = {2},
pages = {115-120},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.2.7903},
url = {https://revistadechimie.ro/Articles.asp?ID=7903}
}

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