Drug Encapsulated Nanomaterials as Carriers Used in Cardiology Field

Luca, Alina Costina; Eva, Lucian; Duceac, Letitia Doina; Mitrea, Geta; Marcu, constantin; Stafie, Liviu; Ciuhodaru, Madalina Irina; Ciomaga, Irina Mihaela; Goroftei, Elena Roxana Bogdan; Hanganu, Elena; Iordache, Alin Constantin

Alina Costina Luca, Lucian Eva, Letitia Doina Duceac, Geta Mitrea,constantin Marcu, Liviu Stafie, Madalina Irina Ciuhodaru, Irina Mihaela Ciomaga, Elena Roxana Bogdan Goroftei, Elena Hanganu, Alin Constantin Iordache

Drug Encapsulated Nanomaterials as Carriers Used in Cardiology Field

Abstract:

Pulmonary arterial hypertension is a disorder of high mortality being described by a progressive increase in pulmonary vascular strength leading to right ventricular damage and death. Endotelin-1 (ET-1) has an important pathogenic fuction in pulmonary hypertension. Bosentan is an oral ET-1 receptor antagonist that proved to be efficient at exercise tolerance in patients with pulmonary hypertension in functional class III and IV. The early trial registered for functional class II patients and evaluated hemodynamic at 6 month. Considerable side effects of bosentan comprise anemia, edema, and transaminase raise. Further studies were developed to determine optimum treatment strategy by eliminating adverse effects of bosentan. The major aim of this work was to prepare bosentan loaded nanoparticles by solvent evaporation technique for a sustained release of the drug by using ethyl cellulose as polymer. Drug and polymer were dissolved in ethanol at different drug-polymer ratios i.e. 1:2 and 1:3. Among the two formulations, 1:3 formulations were appreciated as the best formulation with better drug content (97.5%) and incorporation efficiency (95.5%).

Keywords:
nanomaterials; pulmonary arterial hypertension; cardiological disorders; neurosurgical disorders; delivery systems; drug release

Issue: 2020, Volume 71, Issue 2

Pages: 413-417

Publication date: 2020/3/3

https://doi.org/10.37358/RC.20.2.7944

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
LUCA, A.C., EVA, L., DUCEAC, L.D., MITREA, G., MARCU, C., STAFIE, L., CIUHODARU, M.I., CIOMAGA, I.M., GOROFTEI, E.R.B., HANGANU, E., IORDACHE, A.C., Drug Encapsulated Nanomaterials as Carriers Used in Cardiology Field, Rev. Chim., 71(2), 2020, 413-417.

Vancouver
Luca AC, Eva L, Duceac LD, Mitrea G, Marcu c, Stafie L, Ciuhodaru MI, Ciomaga IM, Goroftei ERB, Hanganu E, Iordache AC. Drug Encapsulated Nanomaterials as Carriers Used in Cardiology Field. Rev. Chim.[internet]. 2020 Feb;71(2):413-417. Available from: https://doi.org/10.37358/RC.20.2.7944

APA 6th edition
Luca, A.C., Eva, L., Duceac, L.D., Mitrea, G., Marcu, c., Stafie, L.,... Iordache, A.C. (2020). Drug Encapsulated Nanomaterials as Carriers Used in Cardiology Field. Revista de Chimie, 71(2), 413-417. https://doi.org/10.37358/RC.20.2.7944

Harvard
Luca, A.C., Eva, L., Duceac, L.D., Mitrea, G., Marcu, c., Stafie, L., Ciuhodaru, M.I., Ciomaga, I.M., Goroftei, E.R.B., Hanganu, E., Iordache, A.C. (2020). 'Drug Encapsulated Nanomaterials as Carriers Used in Cardiology Field', Revista de Chimie, 71(2), pp. 413-417. https://doi.org/10.37358/RC.20.2.7944

IEEE
A.C. Luca, L. Eva, L.D. Duceac, G. Mitrea, c. Marcu, L. Stafie, M.I. Ciuhodaru, I.M. Ciomaga, E.R.B. Goroftei, E. Hanganu, A.C. Iordache, "Drug Encapsulated Nanomaterials as Carriers Used in Cardiology Field". Revista de Chimie, vol. 71, no. 2, pp. 413-417, 2020. [online]. https://doi.org/10.37358/RC.20.2.7944

Text
Alina Costina Luca, Lucian Eva, Letitia Doina Duceac, Geta Mitrea,constantin Marcu, Liviu Stafie, Madalina Irina Ciuhodaru, Irina Mihaela Ciomaga, Elena Roxana Bogdan Goroftei, Elena Hanganu, Alin Constantin Iordache,
Drug Encapsulated Nanomaterials as Carriers Used in Cardiology Field,
Revista de Chimie,
Volume 71, Issue 2,
2020,
Pages 413-417,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.2.7944.
(https://revistadechimie.ro/Articles.asp?ID=7944)
Keywords: nanomaterials; pulmonary arterial hypertension; cardiological disorders; neurosurgical disorders; delivery systems; drug release

RIS
TY - JOUR
T1 - Drug Encapsulated Nanomaterials as Carriers Used in Cardiology Field
A1 - Luca, Alina Costina
A2 - Eva, Lucian
A3 - Duceac, Letitia Doina
A4 - Mitrea, Geta
A5 - Marcu, constantin
A6 - Stafie, Liviu
A7 - Ciuhodaru, Madalina Irina
A8 - Ciomaga, Irina Mihaela
A9 - Goroftei, Elena Roxana Bogdan
A10 - Hanganu, Elena
A11 - Iordache, Alin Constantin
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 2
SP - 413
EP - 417
UR - https://doi.org/10.37358/RC.20.2.7944
KW - nanomaterials
KW - pulmonary arterial hypertension
KW - cardiological disorders
KW - neurosurgical disorders
KW - delivery systems
KW - drug release
ER -

BibTex
@article{RevCh2020P413,
author = {Luca Alina Costina and Eva Lucian and Duceac Letitia Doina and Mitrea Geta and Marcu constantin and Stafie Liviu and Ciuhodaru Madalina Irina and Ciomaga Irina Mihaela and Goroftei Elena Roxana Bogdan and Hanganu Elena and Iordache Alin Constantin},
title = {Drug Encapsulated Nanomaterials as Carriers Used in Cardiology Field},
journal = {Revista de Chimie},
volume = {71},
number = {2},
pages = {413-417},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.2.7944},
url = {https://revistadechimie.ro/Articles.asp?ID=7944}
}

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