Design, Synthesis, and Evaluation of Novel 3-, 4-substituted, and 3,4-di Substituted Quinazoline Derivatives as Antimicrobial Agents

El-Essawy, Farag A.; Alharthi, Abdulrahman I.; Alotaibi, Mshari A.; Wahba, Nancy E.; Boshta, Nader M.

Farag A. El-Essawy, Abdulrahman I. Alharthi, Mshari A. Alotaibi, Nancy E. Wahba, Nader M. Boshta

Design, Synthesis, and Evaluation of Novel 3-, 4-substituted, and 3,4-di Substituted Quinazoline Derivatives as Antimicrobial Agents

Abstract:

A novel series of 3-, 4-substituted, and 3,4-di substituted quinazoline derivatives were prepared via various cyclized regents and most of the newly prepared compounds evaluated for their antimicrobial activities in vitro against Gram-positive, Gram-negative bacterial strains and fungi strains. The structures of the quinazoline derivatives have been confirmed using spectroscopic analyses (IR, NMR, and EI-MS). Some of the synthesized derivatives displayed a moderate antimicrobial activity in comparison with reference drugs, for example compounds 13d, 15a, 17b, 18b, 18d, 25, and 29a-c. Among the synthesized compounds, the pyrimidoqunazoline derivative 6c elicited the highest activity.

Keywords:
Quniazoline; imidazoline; pyrazolo; Trazolo; carbamide; antimicrobial

Issue: 2020, Volume 71, Issue 2

Pages: 422-435

Publication date: 2020/3/3

https://doi.org/10.37358/RC.20.2.7951

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
EL-ESSAWY, F.A., ALHARTHI, A.I., ALOTAIBI, M.A., WAHBA, N.E., BOSHTA, N.M., Design, Synthesis, and Evaluation of Novel 3-, 4-substituted, and 3,4-di Substituted Quinazoline Derivatives as Antimicrobial Agents, Rev. Chim., 71(2), 2020, 422-435.

Vancouver
El-Essawy FA, Alharthi AI, Alotaibi MA, Wahba NE, Boshta NM. Design, Synthesis, and Evaluation of Novel 3-, 4-substituted, and 3,4-di Substituted Quinazoline Derivatives as Antimicrobial Agents. Rev. Chim.[internet]. 2020 Feb;71(2):422-435. Available from: https://doi.org/10.37358/RC.20.2.7951

APA 6th edition
El-Essawy, F.A., Alharthi, A.I., Alotaibi, M.A., Wahba, N.E. & Boshta, N.M. (2020). Design, Synthesis, and Evaluation of Novel 3-, 4-substituted, and 3,4-di Substituted Quinazoline Derivatives as Antimicrobial Agents. Revista de Chimie, 71(2), 422-435. https://doi.org/10.37358/RC.20.2.7951

Harvard
El-Essawy, F.A., Alharthi, A.I., Alotaibi, M.A., Wahba, N.E., Boshta, N.M. (2020). 'Design, Synthesis, and Evaluation of Novel 3-, 4-substituted, and 3,4-di Substituted Quinazoline Derivatives as Antimicrobial Agents', Revista de Chimie, 71(2), pp. 422-435. https://doi.org/10.37358/RC.20.2.7951

IEEE
F.A. El-Essawy, A.I. Alharthi, M.A. Alotaibi, N.E. Wahba, N.M. Boshta, "Design, Synthesis, and Evaluation of Novel 3-, 4-substituted, and 3,4-di Substituted Quinazoline Derivatives as Antimicrobial Agents". Revista de Chimie, vol. 71, no. 2, pp. 422-435, 2020. [online]. https://doi.org/10.37358/RC.20.2.7951

Text
Farag A. El-Essawy, Abdulrahman I. Alharthi, Mshari A. Alotaibi, Nancy E. Wahba, Nader M. Boshta,
Design, Synthesis, and Evaluation of Novel 3-, 4-substituted, and 3,4-di Substituted Quinazoline Derivatives as Antimicrobial Agents,
Revista de Chimie,
Volume 71, Issue 2,
2020,
Pages 422-435,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.2.7951.
(https://revistadechimie.ro/Articles.asp?ID=7951)
Keywords: Quniazoline; imidazoline; pyrazolo; Trazolo; carbamide; antimicrobial

RIS
TY - JOUR
T1 - Design, Synthesis, and Evaluation of Novel 3-, 4-substituted, and 3,4-di Substituted Quinazoline Derivatives as Antimicrobial Agents
A1 - El-Essawy, Farag A.
A2 - Alharthi, Abdulrahman I.
A3 - Alotaibi, Mshari A.
A4 - Wahba, Nancy E.
A5 - Boshta, Nader M.
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 2
SP - 422
EP - 435
UR - https://doi.org/10.37358/RC.20.2.7951
KW - Quniazoline
KW - imidazoline
KW - pyrazolo
KW - Trazolo
KW - carbamide
KW - antimicrobial
ER -

BibTex
@article{RevCh2020P422,
author = {El-Essawy Farag A. and Alharthi Abdulrahman I. and Alotaibi Mshari A. and Wahba Nancy E. and Boshta Nader M.},
title = {Design, Synthesis, and Evaluation of Novel 3-, 4-substituted, and 3,4-di Substituted Quinazoline Derivatives as Antimicrobial Agents},
journal = {Revista de Chimie},
volume = {71},
number = {2},
pages = {422-435},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.2.7951},
url = {https://revistadechimie.ro/Articles.asp?ID=7951}
}

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