Characterization of β-cyclodextrin-diminazene Aceturate Complex Used to Treat Ichthyophthirius multifiliis Infection in Common Carp

Lupu, Andrei-Cristian; Ciobotarescu, Simona; Lisa, Gabriela; Hurduc, Nicolae; Miron, Liviu Dan; Epure, Elena-Luiza

Andrei-Cristian Lupu, Simona Ciobotarescu, Gabriela Lisa, Nicolae Hurduc, Liviu Dan Miron, Elena-Luiza Epure

Characterization of β-cyclodextrin-diminazene Aceturate Complex Used to Treat Ichthyophthirius multifiliis Infection in Common Carp

Abstract:

This study was carried out to explore the efficacy of a veterinary drug, diminazene aceturate (DA) (4,4’-(1-triazene-1,3- dyil)bis-benzenecarboximidamide), in an inclusion complex with β-cyclodextrin (β-CD) as a suitable treatment for parasitic disease caused by Ichthyophthirius multifiliis in farmed carp. The efficacy was determined by the reduction in the infection intensity. The complexes were characterized through thermogravimetric analysis and molecular modeling. The selected stoichiometry for the chosen drug was 1:1. The geometry of inclusion complexes has been investigated by molecular modeling at semi-empirical level in order to find the most favourable structure. Administration of DA in its simple form and included in β-CD was carried out by embedding appropriate doses in the animal feed. Our studies suggest that when DA was used in the complex structure, a reduction in the infection degree and decrease in the trophont size in the treated fish was observed. From these first results of our study, the oral treatment with the complex of DA included in β-CD(DA-β-CD) is found to be a suitable alternative to bath treatments in carp diseases.

Keywords:
carp; cyclodextrin; diminazeneaceturate; molecular modeling

Issue: 2020, Volume 71, Issue 3

Pages: 90-101

Publication date: 2020/4/3

https://doi.org/10.37358/RC.20.3.7977

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
LUPU, A., CIOBOTARESCU, S., LISA, G., HURDUC, N., MIRON, L.D., EPURE, E., Characterization of β-cyclodextrin-diminazene Aceturate Complex Used to Treat Ichthyophthirius multifiliis Infection in Common Carp, Rev. Chim., 71(3), 2020, 90-101.

Vancouver
Lupu A, Ciobotarescu S, Lisa G, Hurduc N, Miron LD, Epure E. Characterization of β-cyclodextrin-diminazene Aceturate Complex Used to Treat Ichthyophthirius multifiliis Infection in Common Carp. Rev. Chim.[internet]. 2020 Mar;71(3):90-101. Available from: https://doi.org/10.37358/RC.20.3.7977

APA 6th edition
Lupu, A., Ciobotarescu, S., Lisa, G., Hurduc, N., Miron, L.D. & Epure, E. (2020). Characterization of β-cyclodextrin-diminazene Aceturate Complex Used to Treat Ichthyophthirius multifiliis Infection in Common Carp. Revista de Chimie, 71(3), 90-101. https://doi.org/10.37358/RC.20.3.7977

Harvard
Lupu, A., Ciobotarescu, S., Lisa, G., Hurduc, N., Miron, L.D., Epure, E. (2020). 'Characterization of β-cyclodextrin-diminazene Aceturate Complex Used to Treat Ichthyophthirius multifiliis Infection in Common Carp', Revista de Chimie, 71(3), pp. 90-101. https://doi.org/10.37358/RC.20.3.7977

IEEE
A. Lupu, S. Ciobotarescu, G. Lisa, N. Hurduc, L.D. Miron, E. Epure, "Characterization of β-cyclodextrin-diminazene Aceturate Complex Used to Treat Ichthyophthirius multifiliis Infection in Common Carp". Revista de Chimie, vol. 71, no. 3, pp. 90-101, 2020. [online]. https://doi.org/10.37358/RC.20.3.7977

Text
Andrei-Cristian Lupu, Simona Ciobotarescu, Gabriela Lisa, Nicolae Hurduc, Liviu Dan Miron, Elena-Luiza Epure,
Characterization of β-cyclodextrin-diminazene Aceturate Complex Used to Treat Ichthyophthirius multifiliis Infection in Common Carp,
Revista de Chimie,
Volume 71, Issue 3,
2020,
Pages 90-101,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.3.7977.
(https://revistadechimie.ro/Articles.asp?ID=7977)
Keywords: carp; cyclodextrin; diminazeneaceturate; molecular modeling

RIS
TY - JOUR
T1 - Characterization of β-cyclodextrin-diminazene Aceturate Complex Used to Treat Ichthyophthirius multifiliis Infection in Common Carp
A1 - Lupu, Andrei-Cristian
A2 - Ciobotarescu, Simona
A3 - Lisa, Gabriela
A4 - Hurduc, Nicolae
A5 - Miron, Liviu Dan
A6 - Epure, Elena-Luiza
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 3
SP - 90
EP - 101
UR - https://doi.org/10.37358/RC.20.3.7977
KW - carp
KW - cyclodextrin
KW - diminazeneaceturate
KW - molecular modeling
ER -

BibTex
@article{RevCh2020P90,
author = {Lupu Andrei-Cristian and Ciobotarescu Simona and Lisa Gabriela and Hurduc Nicolae and Miron Liviu Dan and Epure Elena-Luiza},
title = {Characterization of β-cyclodextrin-diminazene Aceturate Complex Used to Treat Ichthyophthirius multifiliis Infection in Common Carp},
journal = {Revista de Chimie},
volume = {71},
number = {3},
pages = {90-101},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.3.7977},
url = {https://revistadechimie.ro/Articles.asp?ID=7977}
}

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