Fluconazole-Beta-Cyclodextrin Inclusion Complexes. Preparation and Characterization in Solid State

Iftode, Andrada; Racoviceanu, Roxana; Susan, Razvan; Marti, Daniela; Pinzaru, Iulia; Lazau, Radu; Susan, Monica; Gheorghisor, Alexandra; Soica, Codruta; Trandafirescu, Cristina

Andrada Iftode, Roxana Racoviceanu, Razvan Susan, Daniela Marti, Iulia Pinzaru, Radu Lazau, Monica Susan, Alexandra Gheorghisor, Codruta Soica, Cristina Trandafirescu

Fluconazole-Beta-Cyclodextrin Inclusion Complexes. Preparation and Characterization in Solid State

Abstract:

Fluconazole is a bistriazole derivative with antifungal activity. The major weak points of fluconazole are the development of antifungal resistance and low water solubility, which impairs its administration. Binary systems between fluconazole and beta-cyclodextrin were prepared with the aim of obtaining a new delivery system that will overcome the limitations of fluconazole administration. Using two feasible laboratory methods, inclusion complexes between fluconazole and beta-cyclodextrin were obtained. Thermal and spectroscopic analyses were used to characterize the inclusion complexes.

Keywords:
fluconazole; beta-cyclodextrin; inclusion complex

Issue: 2020, Volume 71, Issue 3

Pages: 325-334

Publication date: 2020/4/3

https://doi.org/10.37358/RC.20.3.8005

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
IFTODE, A., RACOVICEANU, R., SUSAN, R., MARTI, D., PINZARU, I., LAZAU, R., SUSAN, M., GHEORGHISOR, A., SOICA, C., TRANDAFIRESCU, C., Fluconazole-Beta-Cyclodextrin Inclusion Complexes. Preparation and Characterization in Solid State, Rev. Chim., 71(3), 2020, 325-334.

Vancouver
Iftode A, Racoviceanu R, Susan R, Marti D, Pinzaru I, Lazau R, Susan M, Gheorghisor A, Soica C, Trandafirescu C. Fluconazole-Beta-Cyclodextrin Inclusion Complexes. Preparation and Characterization in Solid State. Rev. Chim.[internet]. 2020 Mar;71(3):325-334. Available from: https://doi.org/10.37358/RC.20.3.8005

APA 6th edition
Iftode, A., Racoviceanu, R., Susan, R., Marti, D., Pinzaru, I., Lazau, R.,... Trandafirescu, C. (2020). Fluconazole-Beta-Cyclodextrin Inclusion Complexes. Preparation and Characterization in Solid State. Revista de Chimie, 71(3), 325-334. https://doi.org/10.37358/RC.20.3.8005

Harvard
Iftode, A., Racoviceanu, R., Susan, R., Marti, D., Pinzaru, I., Lazau, R., Susan, M., Gheorghisor, A., Soica, C., Trandafirescu, C. (2020). 'Fluconazole-Beta-Cyclodextrin Inclusion Complexes. Preparation and Characterization in Solid State', Revista de Chimie, 71(3), pp. 325-334. https://doi.org/10.37358/RC.20.3.8005

IEEE
A. Iftode, R. Racoviceanu, R. Susan, D. Marti, I. Pinzaru, R. Lazau, M. Susan, A. Gheorghisor, C. Soica, C. Trandafirescu, "Fluconazole-Beta-Cyclodextrin Inclusion Complexes. Preparation and Characterization in Solid State". Revista de Chimie, vol. 71, no. 3, pp. 325-334, 2020. [online]. https://doi.org/10.37358/RC.20.3.8005

Text
Andrada Iftode, Roxana Racoviceanu, Razvan Susan, Daniela Marti, Iulia Pinzaru, Radu Lazau, Monica Susan, Alexandra Gheorghisor, Codruta Soica, Cristina Trandafirescu,
Fluconazole-Beta-Cyclodextrin Inclusion Complexes. Preparation and Characterization in Solid State,
Revista de Chimie,
Volume 71, Issue 3,
2020,
Pages 325-334,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.3.8005.
(https://revistadechimie.ro/Articles.asp?ID=8005)
Keywords: fluconazole; beta-cyclodextrin; inclusion complex

RIS
TY - JOUR
T1 - Fluconazole-Beta-Cyclodextrin Inclusion Complexes. Preparation and Characterization in Solid State
A1 - Iftode, Andrada
A2 - Racoviceanu, Roxana
A3 - Susan, Razvan
A4 - Marti, Daniela
A5 - Pinzaru, Iulia
A6 - Lazau, Radu
A7 - Susan, Monica
A8 - Gheorghisor, Alexandra
A9 - Soica, Codruta
A10 - Trandafirescu, Cristina
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 3
SP - 325
EP - 334
UR - https://doi.org/10.37358/RC.20.3.8005
KW - fluconazole
KW - beta-cyclodextrin
KW - inclusion complex
ER -

BibTex
@article{RevCh2020P325,
author = {Iftode Andrada and Racoviceanu Roxana and Susan Razvan and Marti Daniela and Pinzaru Iulia and Lazau Radu and Susan Monica and Gheorghisor Alexandra and Soica Codruta and Trandafirescu Cristina},
title = {Fluconazole-Beta-Cyclodextrin Inclusion Complexes. Preparation and Characterization in Solid State},
journal = {Revista de Chimie},
volume = {71},
number = {3},
pages = {325-334},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.3.8005},
url = {https://revistadechimie.ro/Articles.asp?ID=8005}
}

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