Analysis of Inclusion Complexes of Clotrimazole and Differently Substituted α, β and γ Cyclodextrins by NMR Spectroscopy

Kelemen, Hajnal; Noszal, Bela; Orgovan, Gabor

Hajnal Kelemen, Bela Noszal, Gabor Orgovan

Analysis of Inclusion Complexes of Clotrimazole and Differently Substituted α, β and γ Cyclodextrins by NMR Spectroscopy

Abstract:

Clotrimazole, a widely used imidazole-type antifungal agent and its cyclodextrin complexes were studied. Stoichiometries, structures and stability constants of the inclusion complexes with fourteen different cyclodextrin derivatives were characterized using NMR spectroscopy as primary technique. The cyclodextrin complexes were found to be of high stability (logK ] 2). 2D ROESY NMR spectra revealed the formation of isomeric complexes with every cyclodextrin studied. The highest stability constant was observed with sulfobutylated β-CD, and interestingly enough the heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin showed the lowest stability.

Keywords:
Clotriomazole; cyclodextrin; inclusion complex; stability; NMR

Issue: 2020, Volume 71, Issue 3

Pages: 497-506

Publication date: 2020/4/3

https://doi.org/10.37358/RC.20.3.8024

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
KELEMEN, H., NOSZAL, B., ORGOVAN, G., Analysis of Inclusion Complexes of Clotrimazole and Differently Substituted α, β and γ Cyclodextrins by NMR Spectroscopy, Rev. Chim., 71(3), 2020, 497-506.

Vancouver
Kelemen H, Noszal B, Orgovan G. Analysis of Inclusion Complexes of Clotrimazole and Differently Substituted α, β and γ Cyclodextrins by NMR Spectroscopy. Rev. Chim.[internet]. 2020 Mar;71(3):497-506. Available from: https://doi.org/10.37358/RC.20.3.8024

APA 6th edition
Kelemen, H., Noszal, B. & Orgovan, G. (2020). Analysis of Inclusion Complexes of Clotrimazole and Differently Substituted α, β and γ Cyclodextrins by NMR Spectroscopy. Revista de Chimie, 71(3), 497-506. https://doi.org/10.37358/RC.20.3.8024

Harvard
Kelemen, H., Noszal, B., Orgovan, G. (2020). 'Analysis of Inclusion Complexes of Clotrimazole and Differently Substituted α, β and γ Cyclodextrins by NMR Spectroscopy', Revista de Chimie, 71(3), pp. 497-506. https://doi.org/10.37358/RC.20.3.8024

IEEE
H. Kelemen, B. Noszal, G. Orgovan, "Analysis of Inclusion Complexes of Clotrimazole and Differently Substituted α, β and γ Cyclodextrins by NMR Spectroscopy". Revista de Chimie, vol. 71, no. 3, pp. 497-506, 2020. [online]. https://doi.org/10.37358/RC.20.3.8024

Text
Hajnal Kelemen, Bela Noszal, Gabor Orgovan,
Analysis of Inclusion Complexes of Clotrimazole and Differently Substituted α, β and γ Cyclodextrins by NMR Spectroscopy,
Revista de Chimie,
Volume 71, Issue 3,
2020,
Pages 497-506,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.3.8024.
(https://revistadechimie.ro/Articles.asp?ID=8024)
Keywords: Clotriomazole; cyclodextrin; inclusion complex; stability; NMR

RIS
TY - JOUR
T1 - Analysis of Inclusion Complexes of Clotrimazole and Differently Substituted α, β and γ Cyclodextrins by NMR Spectroscopy
A1 - Kelemen, Hajnal
A2 - Noszal, Bela
A3 - Orgovan, Gabor
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 3
SP - 497
EP - 506
UR - https://doi.org/10.37358/RC.20.3.8024
KW - Clotriomazole
KW - cyclodextrin
KW - inclusion complex
KW - stability
KW - NMR

ER -

BibTex
@article{RevCh2020P497,
author = {Kelemen Hajnal and Noszal Bela and Orgovan Gabor},
title = {Analysis of Inclusion Complexes of Clotrimazole and Differently Substituted α, β and γ Cyclodextrins by NMR Spectroscopy},
journal = {Revista de Chimie},
volume = {71},
number = {3},
pages = {497-506},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.3.8024},
url = {https://revistadechimie.ro/Articles.asp?ID=8024}
}

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