IgG anti-(Fab’)2 Antibodies in Early Pregnancy Sera of Women with Anti-thyroid Antibodies and Normal Outcome or Spontaneous Abortions

Motoi, Sorin; Dobrescu, Amadeus; Carabineanu, Simona; Blidisel, Alexandru; Stoian, Dana; Carabineanu, Adrian; Boia, Marioara; Craina, Marius; Vladareanu, Radu; Vladareanu, Simona; Terness, Peter; Navolan, Dan

Sorin Motoi, Amadeus Dobrescu, Simona Carabineanu, Alexandru Blidisel, Dana Stoian, Adrian Carabineanu, Marioara Boia, Marius Craina, Radu Vladareanu, Simona Vladareanu, Peter Terness, Dan Navolan

IgG anti-(Fab’)2 Antibodies in Early Pregnancy Sera of Women with Anti-thyroid Antibodies and Normal Outcome or Spontaneous Abortions

Abstract:

Anti-thyroid antibodies (atbs) (anti-TPO, anti-TG, anti-TRH receptor) are autoatbs that recognize specific antigens that belong to thyroid structures. Several mechanisms were proposed to explain the breaking of immunotolerance to thyroid antigens. Our previous studies showed that IgG-anti-F(ab’)2 atbs exert immunosuppresives effect in vitro and inverse correlate with autoatbs in certain autoimmune diseases. Relying on sera from pregnant women with and without anti-thyroid atbs, respectively with or without spontaneous pregnancy loss we intended to analyze the IgG-anti-F(ab)2 atbs titers in sera of these categories of patients. The lot of patients consists of 126 pregnant women out of which 47 had a normal course of pregnancy and 79 experienced spontaneous abortion. Anti-TPO, anti-TG, and IgG-anti-F(ab’)2 atbs titers were measured in sera of these women. Although a difference was found between IgG-anti-F(ab’)2 atbs titer in pregnant women with positive versus negative anti-thyroid atbs, this was not statistically significant. IgG-anti-F(ab)2 atbs titer is higher in women with a normal course of pregnancy compared to women spontaneous pregnancy loss. Differently from other autoimmune diseases, our data show that IgG-anti-F(ab’)2 atbs are not inversely correlated to anti-thyroid atbs titers. Higher IgG-anti-(Fab’)2 atbs titers were found in pregnant women with normal course of pregnancy compared with those with pregnancy loss.

Keywords:
autoimmune thyroiditis; pregnancy; IgG-anti-Fab2; immunotolerance

Issue: 2020, Volume 71, Issue 3

Pages: 608-613

Publication date: 2020/4/3

https://doi.org/10.37358/RC.20.3.8036

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
MOTOI, S., DOBRESCU, A., CARABINEANU, S., BLIDISEL, A., STOIAN, D., CARABINEANU, A., BOIA, M., CRAINA, M., VLADAREANU, R., VLADAREANU, S., TERNESS, P., NAVOLAN, D., IgG anti-(Fab’)2 Antibodies in Early Pregnancy Sera of Women with Anti-thyroid Antibodies and Normal Outcome or Spontaneous Abortions, Rev. Chim., 71(3), 2020, 608-613.

Vancouver
Motoi S, Dobrescu A, Carabineanu S, Blidisel A, Stoian D, Carabineanu A, Boia M, Craina M, Vladareanu R, Vladareanu S, Terness P, Navolan D. IgG anti-(Fab’)2 Antibodies in Early Pregnancy Sera of Women with Anti-thyroid Antibodies and Normal Outcome or Spontaneous Abortions. Rev. Chim.[internet]. 2020 Mar;71(3):608-613. Available from: https://doi.org/10.37358/RC.20.3.8036

APA 6th edition
Motoi, S., Dobrescu, A., Carabineanu, S., Blidisel, A., Stoian, D., Carabineanu, A.,... Navolan, D. (2020). IgG anti-(Fab’)2 Antibodies in Early Pregnancy Sera of Women with Anti-thyroid Antibodies and Normal Outcome or Spontaneous Abortions. Revista de Chimie, 71(3), 608-613. https://doi.org/10.37358/RC.20.3.8036

Harvard
Motoi, S., Dobrescu, A., Carabineanu, S., Blidisel, A., Stoian, D., Carabineanu, A., Boia, M., Craina, M., Vladareanu, R., Vladareanu, S., Terness, P., Navolan, D. (2020). 'IgG anti-(Fab’)2 Antibodies in Early Pregnancy Sera of Women with Anti-thyroid Antibodies and Normal Outcome or Spontaneous Abortions', Revista de Chimie, 71(3), pp. 608-613. https://doi.org/10.37358/RC.20.3.8036

IEEE
S. Motoi, A. Dobrescu, S. Carabineanu, A. Blidisel, D. Stoian, A. Carabineanu, M. Boia, M. Craina, R. Vladareanu, S. Vladareanu, P. Terness, D. Navolan, "IgG anti-(Fab’)2 Antibodies in Early Pregnancy Sera of Women with Anti-thyroid Antibodies and Normal Outcome or Spontaneous Abortions". Revista de Chimie, vol. 71, no. 3, pp. 608-613, 2020. [online]. https://doi.org/10.37358/RC.20.3.8036

Text
Sorin Motoi, Amadeus Dobrescu, Simona Carabineanu, Alexandru Blidisel, Dana Stoian, Adrian Carabineanu, Marioara Boia, Marius Craina, Radu Vladareanu, Simona Vladareanu, Peter Terness, Dan Navolan,
IgG anti-(Fab’)2 Antibodies in Early Pregnancy Sera of Women with Anti-thyroid Antibodies and Normal Outcome or Spontaneous Abortions,
Revista de Chimie,
Volume 71, Issue 3,
2020,
Pages 608-613,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.3.8036.
(https://revistadechimie.ro/Articles.asp?ID=8036)
Keywords: autoimmune thyroiditis; pregnancy; IgG-anti-Fab2; immunotolerance

RIS
TY - JOUR
T1 - IgG anti-(Fab’)2 Antibodies in Early Pregnancy Sera of Women with Anti-thyroid Antibodies and Normal Outcome or Spontaneous Abortions
A1 - Motoi, Sorin
A2 - Dobrescu, Amadeus
A3 - Carabineanu, Simona
A4 - Blidisel, Alexandru
A5 - Stoian, Dana
A6 - Carabineanu, Adrian
A7 - Boia, Marioara
A8 - Craina, Marius
A9 - Vladareanu, Radu
A10 - Vladareanu, Simona
A11 - Terness, Peter
A12 - Navolan, Dan
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 3
SP - 608
EP - 613
UR - https://doi.org/10.37358/RC.20.3.8036
KW - autoimmune thyroiditis
KW - pregnancy
KW - IgG-anti-Fab2
KW - immunotolerance
ER -

BibTex
@article{RevCh2020P608,
author = {Motoi Sorin and Dobrescu Amadeus and Carabineanu Simona and Blidisel Alexandru and Stoian Dana and Carabineanu Adrian and Boia Marioara and Craina Marius and Vladareanu Radu and Vladareanu Simona and Terness Peter and Navolan Dan},
title = {IgG anti-(Fab’)2 Antibodies in Early Pregnancy Sera of Women with Anti-thyroid Antibodies and Normal Outcome or Spontaneous Abortions},
journal = {Revista de Chimie},
volume = {71},
number = {3},
pages = {608-613},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.3.8036},
url = {https://revistadechimie.ro/Articles.asp?ID=8036}
}

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