Synthesis, Characterization and Biological Evaluation of New Schiff Base Ligand derived from 3-hydroxy-benzaldehyde and p-toluidine and its Divalent Metal Ions

Mazhar, Noreen; Aftab, Mehwish; Mahmud, Tariq; Basra, Muhammadasim Raza; Akhtar, Mansoor; Mitu, Liviu

Noreen Mazhar, Mehwish Aftab, Tariq Mahmud, Muhammadasim Raza Basra, Mansoor Akhtar, Liviu Mitu

Synthesis, Characterization and Biological Evaluation of New Schiff Base Ligand derived from 3-hydroxy-benzaldehyde and p-toluidine and its Divalent Metal Ions

Abstract:

A new Schiff base ligand (L) and its transition divalent metal complexes were prepared by the condensation reaction; Reaction was carried out at 70-80 oC by refluxing equimolar ratio of toluidine and aldehyde by continuous stirring for 5-6 hours. Synthesized ligand and Ni(II), Fe(II), Co(II), Mn(II) and Zn(II) bimetallic complexes were characterized by using FT-IR, UV-visible spectroscopy, AAS, Single crystal X-ray analysis, 1H-NMR, molar conductance. Compounds were screened against two fungus Candida glabrata and Candida albicans by agar tube dilution protocol. In vivo anti-inflammatory activity via induced paw edema method and in vitro results by heat induced protein denaturation method were checked. Synthesized compounds were also showed antioxidant activity by using DPPH (diphenylpicrylhydrazyl) and Trolox was used as standard. These studies show that ligand and almost all metal complexes are reactive towards biological assays against reported standard drugs. Zn-L indicates more activeness for antioxidant activity and free ligand while Co-L recognized as more effective anti-inflammatory drug.

Keywords:
Schiff base; Metal complexes; Antioxidant; Anti-inflammatory; Carrageenan

Issue: 2020, Volume 71, Issue 4

Pages: 47-58

Publication date: 2020/5/5

https://doi.org/10.37358/RC.20.4.8042

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
MAZHAR, N., AFTAB, M., MAHMUD, T., BASRA, M.R., AKHTAR, M., MITU, L., Synthesis, Characterization and Biological Evaluation of New Schiff Base Ligand derived from 3-hydroxy-benzaldehyde and p-toluidine and its Divalent Metal Ions, Rev. Chim., 71(4), 2020, 47-58.

Vancouver
Mazhar N, Aftab M, Mahmud T, Basra MR, Akhtar M, Mitu L. Synthesis, Characterization and Biological Evaluation of New Schiff Base Ligand derived from 3-hydroxy-benzaldehyde and p-toluidine and its Divalent Metal Ions. Rev. Chim.[internet]. 2020 Apr;71(4):47-58. Available from: https://doi.org/10.37358/RC.20.4.8042

APA 6th edition
Mazhar, N., Aftab, M., Mahmud, T., Basra, M.R., Akhtar, M. & Mitu, L. (2020). Synthesis, Characterization and Biological Evaluation of New Schiff Base Ligand derived from 3-hydroxy-benzaldehyde and p-toluidine and its Divalent Metal Ions. Revista de Chimie, 71(4), 47-58. https://doi.org/10.37358/RC.20.4.8042

Harvard
Mazhar, N., Aftab, M., Mahmud, T., Basra, M.R., Akhtar, M., Mitu, L. (2020). 'Synthesis, Characterization and Biological Evaluation of New Schiff Base Ligand derived from 3-hydroxy-benzaldehyde and p-toluidine and its Divalent Metal Ions', Revista de Chimie, 71(4), pp. 47-58. https://doi.org/10.37358/RC.20.4.8042

IEEE
N. Mazhar, M. Aftab, T. Mahmud, M.R. Basra, M. Akhtar, L. Mitu, "Synthesis, Characterization and Biological Evaluation of New Schiff Base Ligand derived from 3-hydroxy-benzaldehyde and p-toluidine and its Divalent Metal Ions". Revista de Chimie, vol. 71, no. 4, pp. 47-58, 2020. [online]. https://doi.org/10.37358/RC.20.4.8042

Text
Noreen Mazhar, Mehwish Aftab, Tariq Mahmud, Muhammadasim Raza Basra, Mansoor Akhtar, Liviu Mitu,
Synthesis, Characterization and Biological Evaluation of New Schiff Base Ligand derived from 3-hydroxy-benzaldehyde and p-toluidine and its Divalent Metal Ions,
Revista de Chimie,
Volume 71, Issue 4,
2020,
Pages 47-58,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.4.8042.
(https://revistadechimie.ro/Articles.asp?ID=8042)
Keywords: Schiff base; Metal complexes; Antioxidant; Anti-inflammatory; Carrageenan

RIS
TY - JOUR
T1 - Synthesis, Characterization and Biological Evaluation of New Schiff Base Ligand derived from 3-hydroxy-benzaldehyde and p-toluidine and its Divalent Metal Ions
A1 - Mazhar, Noreen
A2 - Aftab, Mehwish
A3 - Mahmud, Tariq
A4 - Basra, Muhammadasim Raza
A5 - Akhtar, Mansoor
A6 - Mitu, Liviu
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 4
SP - 47
EP - 58
UR - https://doi.org/10.37358/RC.20.4.8042
KW - Schiff base
KW - Metal complexes
KW - Antioxidant
KW - Anti-inflammatory
KW - Carrageenan
ER -

BibTex
@article{RevCh2020P47,
author = {Mazhar Noreen and Aftab Mehwish and Mahmud Tariq and Basra Muhammadasim Raza and Akhtar Mansoor and Mitu Liviu},
title = {Synthesis, Characterization and Biological Evaluation of New Schiff Base Ligand derived from 3-hydroxy-benzaldehyde and p-toluidine and its Divalent Metal Ions},
journal = {Revista de Chimie},
volume = {71},
number = {4},
pages = {47-58},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.4.8042},
url = {https://revistadechimie.ro/Articles.asp?ID=8042}
}

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