Synthesis and Characterization of Coated Iron Oxide Nanoparticles Produced for Drug Delivery in  Viscoelastic Solution

Antoniac, Iulian; Cernea, Alexandru; Petcu, Cristian; Laptoiu, Dan; Tabaras, Diana; Tecu, Camelia; Antoniac, Aurora; Gradinaru, Sebastian

Iulian Antoniac, Alexandru Cernea, Cristian Petcu, Dan Laptoiu, Diana Tabaras, Camelia Tecu, Aurora Antoniac, Sebastian Gradinaru

Synthesis and Characterization of Coated Iron Oxide Nanoparticles Produced for Drug Delivery in Viscoelastic Solution

Abstract:

Drug delivery systems enable transportation of drugs in the body, controlling the time, rate or place of the release rendering them ideal for local treatments. When treating joint diseases such as osteoarthritis of the knee the therapeutically substances are given intra-particularly. Magnetic nanoparticles are used so that the solution containing the treatment can be easily directed from the outside with the help of magnets allowing the drug to reach the maximum concentration at the area of interest. Functionalization of nanoparticles is necessary to obtain viscoelastic solutions with optimal physico-chemical and medical properties. This paper presents a superior method of delivering intraarticular hyaluronic acid using iron oxide magnetic nanoparticles (Fe2O3) which were embedded in tetramethylammonium hydroxide (TMOH) and coated using a layer-by-layer technique with hyaluronic acid and inulin. TMOH was chosen for a better dispersion of nanoparticles in the viscoelastic solution, eliminating the risk of agglomerations, hyaluronic acid and inulin being used for medical purposes.

Keywords:
magnetic nanoparticles; hyaluronic acid; functionalization; viscoelastic solution

Issue: 2020, Volume 71, Issue 4

Pages: 145-154

Publication date: 2020/5/5

https://doi.org/10.37358/RC.20.4.8053

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
ANTONIAC, I., CERNEA, A., PETCU, C., LAPTOIU, D., TABARAS, D., TECU, C., ANTONIAC, A., GRADINARU, S., Synthesis and Characterization of Coated Iron Oxide Nanoparticles Produced for Drug Delivery in Viscoelastic Solution, Rev. Chim., 71(4), 2020, 145-154.

Vancouver
Antoniac I, Cernea A, Petcu C, Laptoiu D, Tabaras D, Tecu C, Antoniac A, Gradinaru S. Synthesis and Characterization of Coated Iron Oxide Nanoparticles Produced for Drug Delivery in Viscoelastic Solution. Rev. Chim.[internet]. 2020 Apr;71(4):145-154. Available from: https://doi.org/10.37358/RC.20.4.8053

APA 6th edition
Antoniac, I., Cernea, A., Petcu, C., Laptoiu, D., Tabaras, D., Tecu, C., Antoniac, A. & Gradinaru, S. (2020). Synthesis and Characterization of Coated Iron Oxide Nanoparticles Produced for Drug Delivery in Viscoelastic Solution. Revista de Chimie, 71(4), 145-154. https://doi.org/10.37358/RC.20.4.8053

Harvard
Antoniac, I., Cernea, A., Petcu, C., Laptoiu, D., Tabaras, D., Tecu, C., Antoniac, A., Gradinaru, S. (2020). 'Synthesis and Characterization of Coated Iron Oxide Nanoparticles Produced for Drug Delivery in Viscoelastic Solution', Revista de Chimie, 71(4), pp. 145-154. https://doi.org/10.37358/RC.20.4.8053

IEEE
I. Antoniac, A. Cernea, C. Petcu, D. Laptoiu, D. Tabaras, C. Tecu, A. Antoniac, S. Gradinaru, "Synthesis and Characterization of Coated Iron Oxide Nanoparticles Produced for Drug Delivery in Viscoelastic Solution". Revista de Chimie, vol. 71, no. 4, pp. 145-154, 2020. [online]. https://doi.org/10.37358/RC.20.4.8053

Text
Iulian Antoniac, Alexandru Cernea, Cristian Petcu, Dan Laptoiu, Diana Tabaras, Camelia Tecu, Aurora Antoniac, Sebastian Gradinaru,
Synthesis and Characterization of Coated Iron Oxide Nanoparticles Produced for Drug Delivery in Viscoelastic Solution,
Revista de Chimie,
Volume 71, Issue 4,
2020,
Pages 145-154,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.4.8053.
(https://revistadechimie.ro/Articles.asp?ID=8053)
Keywords: magnetic nanoparticles; hyaluronic acid; functionalization; viscoelastic solution

RIS
TY - JOUR
T1 - Synthesis and Characterization of Coated Iron Oxide Nanoparticles Produced for Drug Delivery in Viscoelastic Solution
A1 - Antoniac, Iulian
A2 - Cernea, Alexandru
A3 - Petcu, Cristian
A4 - Laptoiu, Dan
A5 - Tabaras, Diana
A6 - Tecu, Camelia
A7 - Antoniac, Aurora
A8 - Gradinaru, Sebastian
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 4
SP - 145
EP - 154
UR - https://doi.org/10.37358/RC.20.4.8053
KW - magnetic nanoparticles
KW - hyaluronic acid
KW - functionalization
KW - viscoelastic solution
ER -

BibTex
@article{RevCh2020P145,
author = {Antoniac Iulian and Cernea Alexandru and Petcu Cristian and Laptoiu Dan and Tabaras Diana and Tecu Camelia and Antoniac Aurora and Gradinaru Sebastian},
title = {Synthesis and Characterization of Coated Iron Oxide Nanoparticles Produced for Drug Delivery in Viscoelastic Solution},
journal = {Revista de Chimie},
volume = {71},
number = {4},
pages = {145-154},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.4.8053},
url = {https://revistadechimie.ro/Articles.asp?ID=8053}
}

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