Coordination Compounds of Platinum and Palladium with Mixed Ligands (Usnic Acid and 1-(o-Tolyl) Biguanide) - Synthesis, Spectral Characterization and Biological Activity

Calinescu, Mirela; Oprea, Ovidiu; Stoica, Catalina; Nita-Lazar, Mihai; Mihalache, Madalina

Mirela Calinescu, Ovidiu Oprea, Catalina Stoica, Mihai Nita-Lazar, Madalina Mihalache

Coordination Compounds of Platinum and Palladium with Mixed Ligands (Usnic Acid and 1-(o-Tolyl) Biguanide) - Synthesis, Spectral Characterization and Biological Activity

Abstract:

Four coordination compounds of Pd(II), Pt(II) and Pt(IV) with usnic acid (H3AU) and 1-(o-tolyl)biguanide (TB) as ligands have been synthesized in view of their potential as antimicrobial, antifungal and antitumor agents. The metal complexes have been characterized by elemental and thermogravimetrical analyses, infrared and electronic spectra. Based on these studies, the following formulas have been proposed for the complexes: [Pd(TB)(H3AU)]PdCl4 (C1), [Pd(TB)(H2AU)] CH3COO (C2), [Pt(TB)(H2AU)Cl2]Cl (C3) and [Pt(TB)(H2AU)]Cl (C4), where H2AU is deprotonated usnic acid. The in vitro biological activities of the new complexes were tested against Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Candida albicans ATCC 10231 and HeLa tumor cells. All complexes were found to have good biological properties and therefore they can be further explored in therapeutic applications.

Keywords:
biguanides; usnic acid; coordination compounds; biological activity

Issue: 2020, Volume 71, Issue 4

Pages: 336-346

Publication date: 2020/5/5

https://doi.org/10.37358/RC.20.4.8073

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
CALINESCU, M., OPREA, O., STOICA, C., NITA-LAZAR, M., MIHALACHE, M., Coordination Compounds of Platinum and Palladium with Mixed Ligands (Usnic Acid and 1-(o-Tolyl) Biguanide) - Synthesis, Spectral Characterization and Biological Activity, Rev. Chim., 71(4), 2020, 336-346.

Vancouver
Calinescu M, Oprea O, Stoica C, Nita-Lazar M, Mihalache M. Coordination Compounds of Platinum and Palladium with Mixed Ligands (Usnic Acid and 1-(o-Tolyl) Biguanide) - Synthesis, Spectral Characterization and Biological Activity. Rev. Chim.[internet]. 2020 Apr;71(4):336-346. Available from: https://doi.org/10.37358/RC.20.4.8073

APA 6th edition
Calinescu, M., Oprea, O., Stoica, C., Nita-Lazar, M. & Mihalache, M. (2020). Coordination Compounds of Platinum and Palladium with Mixed Ligands (Usnic Acid and 1-(o-Tolyl) Biguanide) - Synthesis, Spectral Characterization and Biological Activity. Revista de Chimie, 71(4), 336-346. https://doi.org/10.37358/RC.20.4.8073

Harvard
Calinescu, M., Oprea, O., Stoica, C., Nita-Lazar, M., Mihalache, M. (2020). 'Coordination Compounds of Platinum and Palladium with Mixed Ligands (Usnic Acid and 1-(o-Tolyl) Biguanide) - Synthesis, Spectral Characterization and Biological Activity', Revista de Chimie, 71(4), pp. 336-346. https://doi.org/10.37358/RC.20.4.8073

IEEE
M. Calinescu, O. Oprea, C. Stoica, M. Nita-Lazar, M. Mihalache, "Coordination Compounds of Platinum and Palladium with Mixed Ligands (Usnic Acid and 1-(o-Tolyl) Biguanide) - Synthesis, Spectral Characterization and Biological Activity". Revista de Chimie, vol. 71, no. 4, pp. 336-346, 2020. [online]. https://doi.org/10.37358/RC.20.4.8073

Text
Mirela Calinescu, Ovidiu Oprea, Catalina Stoica, Mihai Nita-Lazar, Madalina Mihalache,
Coordination Compounds of Platinum and Palladium with Mixed Ligands (Usnic Acid and 1-(o-Tolyl) Biguanide) - Synthesis, Spectral Characterization and Biological Activity,
Revista de Chimie,
Volume 71, Issue 4,
2020,
Pages 336-346,
ISSN 2668-8212,
https://doi.org/10.37358/RC.20.4.8073.
(https://revistadechimie.ro/Articles.asp?ID=8073)
Keywords: biguanides; usnic acid; coordination compounds; biological activity

RIS
TY - JOUR
T1 - Coordination Compounds of Platinum and Palladium with Mixed Ligands (Usnic Acid and 1-(o-Tolyl) Biguanide) - Synthesis, Spectral Characterization and Biological Activity
A1 - Calinescu, Mirela
A2 - Oprea, Ovidiu
A3 - Stoica, Catalina
A4 - Nita-Lazar, Mihai
A5 - Mihalache, Madalina
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2020
VL - 71
IS - 4
SP - 336
EP - 346
UR - https://doi.org/10.37358/RC.20.4.8073
KW - biguanides
KW - usnic acid
KW - coordination compounds
KW - biological activity
ER -

BibTex
@article{RevCh2020P336,
author = {Calinescu Mirela and Oprea Ovidiu and Stoica Catalina and Nita-Lazar Mihai and Mihalache Madalina},
title = {Coordination Compounds of Platinum and Palladium with Mixed Ligands (Usnic Acid and 1-(o-Tolyl) Biguanide) - Synthesis, Spectral Characterization and Biological Activity},
journal = {Revista de Chimie},
volume = {71},
number = {4},
pages = {336-346},
year = {2020},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.20.4.8073},
url = {https://revistadechimie.ro/Articles.asp?ID=8073}
}

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